Oklahoma COBRE in Structural Biology

俄克拉荷马州 COBRE 结构生物学

基本信息

批准号：
10631144
负责人：
ANN H WEST
金额：
$ 114.15万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631144
关键词：
Address Area Award Biological Sciences Centers of Research Excellence Client Communities Consultations Core Facility Cryoelectron Microscopy Crystallization Data Collection Development Education Educational workshop Faculty Fees Freezing Funding Goals Grant Group Meetings Health Sciences Institution Interdisciplinary Study Location Mentors Mission Molecular Structure Oklahoma Paper Peer Review Phase Pilot Projects Postdoctoral Fellow Preparation Production Proteins Publishing Research Research Personnel Research Project Grants Research Support Research Training Resources Roentgen Rays Sampling Series Services Structure Students Training Training and Education Universities Visit base biophysical analysis biophysical properties career experience faculty support human disease insight instrumentation macromolecule mid-career faculty novel therapeutic intervention outreach posters programs protein expression protein purification structural biology symposium

项目摘要

Project Summary (Overall Center) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase 1 funding. The OCSB supports faculty research projects and two research core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. The overall objective of this Phase 3 application is to provide essential research support in the State of Oklahoma and the region in the form of shared core facilities, training and expertise in structural biology, and an open competitive pilot project program. The specific aims of this Phase 3 application are to: 1) Sustain and enhance the research cores established and developed in Phases 1 and 2 and facilitate their transition to self-sustaining cores and 2) Increase the critical mass of investigators in the field of structural biology in the State of Oklahoma by supporting researchers through a competitive pilot project program.

项目概要（整体中心）结构生物学是一个多学科研究领域，重点关注结构生物学之间的重要关系大分子结构和功能。俄克拉荷马州生物医学卓越研究中心 (COBRE) 结构生物学 (OCSB) 成立于 2012 年，获得第一阶段资金。 OCSB 支持教师研究 OU-诺曼和 OU 健康科学中心校园的项目和两个研究核心设施具有生物医学重要性的大分子结晶、X 射线数据收集、蛋白质表达和纯化和生物物理分析。第三阶段应用的总体目标是提供必要的俄克拉荷马州和该地区的研究支持以共享核心设施、培训和结构生物学方面的专业知识，以及开放的竞争性试点项目计划。第三阶段的具体目标申请的目的是： 1) 维持和加强在第一阶段和第二阶段建立和开发的研究核心促进其向自我维持核心的过渡；2) 增加该领域研究人员的临界数量俄克拉荷马州的结构生物学通过竞争性试点项目支持研究人员程序。