Variable-Field Nuclear Magnetic Relaxometer

变场核磁松弛计

• 批准号: 10630565
• 负责人: Eric Michael Gale
• 金额: $ 41.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2025-05-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630565
• 关键词: 20 year old; Blood; Books; Clinical; Devices; Engineering; Functional Magnetic Resonance Imaging; Hematocrit procedure; Hour; Human; Image; Ions; MRI Scans; Magnetic Resonance Imaging; Magnetism; Measurement; Measures; Molecular; NMR Spectroscopy; Nuclear; Pathologic; Physiological; Relaxation; Research Personnel; Resources; Sampling; Signal Transduction; Structure; Technology; Temperature; Testing; Tissues; biological systems; image guided; imaging biomarker; imaging probe; imaging study; innovation; instrument; instrumentation; macromolecule; magnetic field; physiologic model; small molecule

Project Summary/ Abstract The MGH Institute for Innovation in Imaging (i3) requests nuclear magnetic relaxometry instrumentation with field cycling capabilities between 0.00023T and 3.0T. A relaxometer is a device that measures the nuclear magnetic relaxation times (T1, T2) of samples as a function of applied magnetic field. Relaxometry measurements performed at a given field strength are used to screen the efficacy small molecule and macromolecule probes that are used in magnetic resonance imaging (MRI). Relaxometry measurements performed as a function of varied field and/ or temperature us to characterize the molecular mechanisms that underpin nuclear magnetic relaxation enhancement and thus guide molecular strategies to probe optimization. Relaxometry can also be used to interrogate interactions between biomolecules and paramagnetic ions, to characterize and quantify molecular level pathologic changes in tissue, or to better understand how physiological fluctuations in blood or tissue may influence signal in an MRI scan. There is currently no functioning relaxometer at MGH. Until recently, MGH researchers screened the efficacy of newly developed relaxation agents using one of two fixed-field relaxometers functioning at 0.47T and 1.4T. However, both instruments are over 20 years old and are no longer operational. Relaxometry measurements can occasionally be performed using MRI scanners at the MGH Martinos Center, but the scanners are heavily booked for imaging studies, researchers are billed $655 and $300 per hour for the use of clinical and non-clinical scanners, and current experimental configuration provide poor control over sample temperature. Measurements can also occasionally be performed using the 11.7T or 14.1T vertical bore magnets used for NMR spectroscopy in the Charlestown Navy Yard. These spectrometers enable variable temperature recordings but these spectrometers operate at very high field compared to clinical MR scanners and the vast majority of non-clinical MR scanners, thus diminishing the relevance of measurements performed to screen MR imaging probe efficacy. The requested instrumentation will (1) replace the 0.47T and 1.4T relaxometers that have been heavily relied upon to screen new MR imaging probes, and (2) provide a unique and extremely powerful experimental resource that can be applied to interrogate molecular mechanisms that govern nuclear magnetic relaxation, guide imaging probe optimization, interrogate structure, dynamics, and speciation of biomolecules in biological systems, to facilitate engineering of phantoms to test on new MRI scanner technology being developed in parallel, to develop quantitative models of how physiologic changes (pO2, hematocrit) and MR imaging probes impact human fMRI signals, and to guide identification of imaging biomarkers.

项目摘要/摘要 MGH成像创新研究所（I3）请求核磁性释放仪器 0.00023t至3.0t之间的场循环功能。松弛计是一种测量核的装置 样品的磁弛豫时间（T1，T2）与施加磁场的关系。放松计 在给定场强的测量值用于筛选功效小分子和 用于磁共振成像（MRI）的大分子探针。放松测量值 作为各种场和/或温度的函数，表征了分子机制 核磁松弛的基础增强，从而指导分子策略探测优化。 松弛计也可用于询问生物分子与顺磁离子之间的相互作用， 表征和量化组织中分子水平的病理变化，或者更好地了解生理 血液或组织的波动可能会影响MRI扫描中的信号。 当前在MGH上没有功能的松弛计。直到最近，MGH研究人员还筛选了功效 新开发的松弛剂使用两个固定场松弛计之一，在0.47T和1.4T下起作用。 但是，这两种乐器都超过20年，并且不再是运营的。放松测量值 偶尔可以在MGH Martinos中心使用MRI扫描仪进行，但扫描仪很大 用于成像研究的预订，研究人员的使用费用为655美元和每小时300美元，用于使用临床和非临床 扫描仪和当前的实验构型对样品温度的控制不佳。测量 还可以使用用于NMR光谱法的11.7T或14.1T垂直孔磁铁进行 在查尔斯敦海军院子里。这些光谱仪启用可变温度记录，但 与临床MR扫描仪相比，光谱仪在非常高的场上工作和绝大多数非临床 MR扫描仪，因此减少了对筛选MR成像探针功效的测量的相关性。 请求的仪器将（1）替换已严重依赖的0.47T和1.4T松弛计 筛选新的MR成像探针，（2）提供独特而极其强大的实验资源 可以应用于询问控制核磁松弛的分子机制，引导成像 生物系统中生物分子的探针优化，询问结构，动力学和物种形成， 促进对幻影的工程，以并联开发新的MRI扫描仪技术测试，以开发 生理变化（PO2，血细胞比容）和MR成像探针如何影响人fMRI的定量模型 信号，并指导成像生物标志物的识别。