Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Core

生物分析、心脏代谢表型、成像和组织学核心

• 批准号: 10630579
• 负责人: Barbara T Alexander
• 金额: $ 26.43万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630579
• 关键词: Basic Science; Behavioral; Biochemical; Biological Assay; Blood-Borne Pathogens; Businesses; Capital; Cardiorenal syndrome; Cardiovascular Diseases; Centers of Research Excellence; Charge; Chemistry; Clinical; Core Facility; Coupled; Data; Development; Discipline; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fostering; Funding; Funding Agency; Generations; Genetic; Goals; Grant; Hazardous Chemicals; High Prevalence; Histologic; Histology; Historically Black Colleges and Universities; Human Resources; Image; Immunohistochemistry; In Vitro; Individual; Industry; Infrastructure; Institution; Kidney Diseases; Laboratories; Maintenance; Measurement; Mentors; Metabolic; Metabolic Diseases; Mississippi; Modeling; Morbidity - disease rate; Obesity; Phase; Phenotype; Physiological; Policies; Population; Postdoctoral Fellow; Procedures; Publications; Radiation; Radioimmunoassay; Recovery; Regulation; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Safety; Scientist; Services; Standardization; Students; Supervision; System; Technical Expertise; Technology; Testing; Training; United States; United States National Institutes of Health; Universities; Update; cardiometabolism; cost; doctoral student; experience; improved; in vivo; in vivo imaging; instrumentation; member; mortality; multidisciplinary; new technology; novel strategies; pharmacologic; pre-doctoral; service utilization; success

CORE B – BIOANALYTICAL, CARDIOMETABOLIC PHENOTYPING, IMAGING AND HISTOLOGY CORE PROJECT SUMMARY/ABSTRACT The Cardiorenal and Metabolic Diseases Research Center (CMDRC) was established to enhance research infrastructure and provide mentoring to increase the ability of CMDRC investigators to successfully compete for independent NIH funding. The Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Sub-Cores were established during Phases 1 and 2 to serve as a resource for the CMDRC, and Core B has had a transformative effect on COBRE Junior Investigators and Pilot Grant investigators, and other users of Core B. During Phase 1 and Phase 2 of COBRE support, Core B established consolidated, highly specialized services and state-of-the-art resources critical to cardiorenal and metabolic diseases researchers; technologies and services that would otherwise not be available to individual investigators. Core B is staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators. Core B has multiple components that include: the Bioanalytical Sub-Core that provides centralized radioimmunoassay (RIA), ELISA, and other chemistry analyses; the Cardiometabolic Phenotyping Sub-Core that provides centrally located, state-of-the-art, highly specialized in vivo phenotypical testing to characterize physiological and behavioral parameters in genetic and pharmacological research models of obesity, cardiovascular and metabolic disease; and the Imaging and Histology Sub-Cores that provide access to state- of–the-art imaging equipment as well as histology, immunohistochemistry, and other key services. Over 88 investigators from 18 basic science and clinical departments at UMMC and 11 researchers from 8 other institutions including Jackson State University, a Historically Black Colleges and Universities (HBCUs), used Core B services and resources. Usage of Core B facilitated the generation of >260 publications and the funding of 135 extramural grants from NIH and other non-profit funding agencies. Establishment of Core B as a Fee-for Service Recharge Center initiated our Business Plan for our Model for Sustainability. The incorporation of Centralized Billing and initiation of an Online Core Management System coupled to the commitment by UMMC for continued support for capital maintenance and updates for capital equipment, and the significant increase in independent extramural funding by users of Core B that established our Research Pool will ensure long-term sustainability. Core B will continue to build upon our success so we can provide continuous support for existing infrastructure and expand Core offerings.

核心B-生物分析，心脏代谢表型，成像和组织学核心核心 项目摘要/摘要 建立了心脏素和代谢疾病研究中心（CMDRC），以增强研究 基础架构并为CMDRC调查人员成功竞争的能力提供指导 独立的NIH资金。 是在第1阶段和第2阶段建立的，以作为CMDRC的资源，而Core B有A 对Cobre初级调查人员和试点赠款调查人员以及CoreB的其他用户的变革性影响。 在COBRE支持的第1阶段和第2阶段，核心B建立了合并，高度专业化的服务 最新的资源对心脏和代谢疾病至关重要 否则将无法提供个人调查员的服务。 不仅有能力执行各种必需品Serso的人员也能够 提供培训和协助ost开发新的研究方法，以满足毛c的不断变化的需求 研究人员B有多个组件，包括：提供集中的生物分析子核 放射免疫分析（RIA），ELISA和其他化学分析； 提供中心位于中心位置，最先进的，高度专业的体内表型测试以表征 遗传和药物结合学研究模型的生理学和行为参数， 心血管和代谢疾病； - ART成像设备以及组织学，免疫组织化学和其他关键服务 UMMC的18个基础科学和临床部门的研究人员和其他8个研究人员 杰克逊州立大学（Jackson State University），历史悠久的黑人学院（HBCU），包括铭文 核心的核心服务和核心B的使用促进了> 260个出版物的产生 NIH和其他非营利性资金机构的135次授予。 服务中心为我们的可持续性启动了我们的业务计划 集中计费和在线核心管理系统的启动，加上UMMC的承诺 为了持续支持资本维护和资本设备的更新，以及显着增加 核心B用户的独立壁外资金建立了我们的研究池，将确保长期 可持续性B将继续以我们的成功为基础 基础架构并扩展核心产品。