Comprehensive Research Experiences to Advance Training and Education (CREATE) for Future Cancer Researchers

全面的研究经验可促进未来癌症研究人员的培训和教育 (CREATE)

• 批准号: 10664861
• 负责人: Priyamvada Rai
• 金额: $ 27.37万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664861
• 关键词: Academic Training; Academic skills; Address; Affect; Area; Bioinformatics; Biological Markers; Biology; Biomedical Research; Biotechnology; Cancer Burden; Cancer Control; Cancer Research Project; Catchment Area; Cause of Death; Clinical Oncology; Clinical Trials Design; Communities; Community Health; Community Outreach; Complement; Comprehensive Cancer Center; Country; Coupled; Data Analyses; Data Set; Databases; Development; Diagnosis; Disease; Education; Educational Curriculum; Educational workshop; Ensure; Environment; Epigenetic Process; Exposure to; Faculty; Feedback; Fellowship Program; Florida; Future; Genome; Goals; Health Disparities Research; Immunotherapy; Incidence; Incubators; Individual; Infrastructure; Institution; Instruction; Knowledge; Literature; Location; Malignant Neoplasms; Mentors; Methodology; Mining; Modernization; Monitor; Oncologist; Oncology; Outcome; Participant; Patients; Physicians; Population; Positioning Attribute; Public Health; Qualifying; Reading; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Students; Therapeutic; Training; Training and Education; Treatment outcome; Tumor Biology; United States; Universities; Validation; Writing; anticancer research; burden of illness; cancer health disparity; career; career development; commercialization; drug development; drug discovery; efficacy evaluation; epigenome; experience; faculty mentor; faculty research; field trip; hands on instruction; innovation; insight; interest; medical schools; next generation; novel; outreach; peer; peer coaching; peer networks; personalized medicine; phase I trial; programs; recruit; screening; skills; sociodemographics; socioeconomic disparity; summer program; symposium; technological innovation; therapeutic target; tool; trial design; undergraduate research; undergraduate research experience; undergraduate student

Project Summary Despite major advances in diagnosis and treatment, there remains a need for sustained research and therapeutic innovation to reduce cancer burden. Besides experimental biology, the landscape of oncology research now encompasses computational patient dataset mining for new biomarkers and therapeutic targets, genome and epigenome analysis-based personalized medicine, and application of how sociodemographic and socioeconomic disparities affect cancer incidence and outcomes. The next generation of researchers must receive early exposure to this comprehensive, integrated view of modern oncology, so they can make informed and innovative decisions regarding specialization or cross-specialization options throughout their future education. The proposed CREATE program for future cancer researchers aims to accomplish this goal by integrating a 10-week mentored undergraduate cancer research program with foundational modules on computational drug discovery and development and cancer health disparities-based research. This program will build and expand on the UMMSOM/Sylvester Comprehensive Cancer Center (SCCC)-sponsored pre-existing summer program infrastructure to facilitate research projects tailored to individual scholar interest alongside comprehensive academic and career development support. Complementarily, through a hands-on mini-project, CREATE scholars will receive hands-on instruction in bioinformatics and computational approaches required to develop a robust therapeutic pipeline. SCCC serves a diverse catchment area that will be leveraged to provide CREATE scholars with unique opportunities for understanding the impact of cancer disparities at the community level on disease incidence and treatment outcomes. Currently, only undergraduates actively engaged in computational projects or health disparities research benefit from their exposure to these essential research areas. Our proposed curriculum will ensure all our scholars develop a working understanding of these areas in addition to accomplishing substantive bench research with world-class faculty mentors. CREATE scholars will also experience clinical oncology components including physician shadowing and basic instruction in Phase I trial design. They will receive sustained programmatic and peer mentoring support as they navigate the next steps in their academic training. An important aspect of enhancing the cancer research workforce is outreach and engagement with student populations who do not have research opportunities due to their location or circumstances. SCCC is only the second NCI-designated center in the entire state of Florida. As such, our institutional summer program receives more qualified applicants than we can support, demonstrating a clear interest from undergraduates across the country in our cancer research resources and environment. We are, thus, in a unique position to offer the innovative CREATE program to help produce the next generation of cancer researchers with the comprehensive training and knowledge to succeed in oncology-based careers.

项目摘要 尽管诊断和治疗方面取得了重大进展，但仍需要进行持续研究和 治疗创新以减轻癌症负担。除了实验生物学外，肿瘤学的景观 现在，研究包括针对新的生物标志物和治疗靶标的计算患者数据集挖掘， 基因组和表观基因组分析的个性化医学以及社会人口统计学和如何应用 社会经济差异会影响癌症的发病率和结果。下一代研究人员必须 尽早接触这种现代肿瘤学的全面，整合的观点，因此他们可以使知情 以及有关专业化或跨特殊选择的创新决定 教育。拟议的未来癌症研究人员的创建计划旨在通过 将一项为期10周的指导本科癌症研究计划与基础模块相结合 计算药物发现与发展以及基于癌症健康差异的研究。这个程序将 建立和扩展在脐带/西尔维斯特综合癌症中心（SCCC）赞助的先前存在的 夏季计划基础设施，以促进针对个人学者兴趣的研究项目 全面的学术和职业发展支持。通过动手迷你项目互补， 创建学者将获得所需的生物信息学和计算方法的动手指导 开发强大的治疗管道。 SCCC服务于一个不同的集水区，该区域将被利用 创建具有理解癌症差异对社区影响的独特机会的学者 疾病发病率和治疗结果水平。目前，只有本科生积极从事 计算项目或健康差异研究受益于其对这些基本研究的接触 区域。我们提议的课程将确保我们所有的学者在 除了与世界一流的教师导师一起完成实质性的板凳研究。创建学者 还体验临床肿瘤学成分，包括医师的阴影和第一阶段的基本教学 试用设计。他们将在接下来的过程中获得持续的程序和同伴指导支持 他们的学术培训的步骤。加强癌症研究人员的一个重要方面是外展 以及与由于其位置或没有研究机会的学生群体的参与 情况。 SCCC只是整个佛罗里达州的第二个NCI指定的中心。因此，我们的 机构夏季计划收到的申请人比我们支持的要多，证明了一个明确的申请人 我们的癌症研究资源和环境中全国各地的大学生的兴趣。我们是 因此，以独特的位置提供创新的创建计划，以帮助产生下一代癌症 接受全面培训和知识的研究人员，以成功地从事肿瘤学的职业。