Center for Sleep-Related Symptom Science

睡眠相关症状科学中心

• 批准号: 8878074
• 负责人: Gayle Giboney Page
• 金额: $ 35.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878074
• 关键词: Adult; Affect; Cardiovascular Diseases; Chronic Disease; Clinical; Communities; Diabetes Mellitus; Fatigue; Goals; Growth; Heart Diseases; Life Style; Mental Depression; Mission; Modeling; Morbidity - disease rate; Obesity; Outcome; Pain; Polysomnography; Population; Public Health; Research; Research Infrastructure; Research Personnel; School Nursing; Science; Sleep; Sleep disturbances; Symptoms; Universities; Work; biobehavior; catalyst; disability; innovation; interdisciplinary collaboration; meetings; mortality; organizational structure; programs; promoter

DESCRIPTION (provided by applicant): More than one-fourth of the adult population of the U.S. suffers from sleep disturbances now known to contribute to disability, morbidity and mortality. Sleep disturbance is entangled in chronic illnesses such as cardiovascular disease, diabetes and depression; in symptom clusters such as pain and fatigue; and as a consequence of obesity, life-style and work. The long term goal is to build a sustainable model research Center for Sleep-Related Symptom Science with a mission of increasing the conduct of high quality, innovative interdisciplinary biobehavioral sleep research. We propose to create a Center that will serve as a catalyst for investigators to develop the necessary expertise to undertake the measurement of sleep outcomes as well as a promoter of interdisciplinary collaboration and partnerships to enable sustainable growth in the conduct of sleep research. The specific aims for this Center providing the framework to meet this mission are to: (1) provide a research infrastructure dedicated to sleep-related symptom science; (2) expand the number of research investigators involved in high quality, innovative interdisciplinary biobehavioral sleep research; and (3) enable sustainable growth in research programs prominently including sleep. Two cores, the Administrative Core and the Sleep Measurement Core, are proposed to implement the Center aims. Sustainability is accomplished by: (a) building cadre of translational and clinica researchers for whom sleep is the primary focus of their programs of research; (b) building a critical mass of investigators with sleep as a major variable of focus in their program of research; and (c) engaging investigators in which sleep disturbance is an important component in their program of research, e.g., cardiovascular disease and treatment-related sleep consequences. At the organizational level, sustainability is accomplished by the continuation and integration of Center activities into the organizational structure in the School of Nursing and the broader Johns Hopkins University community.

描述（由申请人提供）：超过四分之一的美国成年人口患有睡眠障碍，目前已知这会导致残疾、发病和死亡。睡眠障碍与心血管疾病、糖尿病和抑郁症等慢性疾病有关；疼痛和疲劳等症状群；以及肥胖、生活方式和工作的结果。长期目标是建立一个可持续的睡眠相关症状科学模型研究中心，其使命是加强高质量、创新的跨学科生物行为睡眠研究的开展。我们建议建立一个中心，作为调查人员发展必要专业知识以开展调查的催化剂。 睡眠结果的测量以及跨学科合作和伙伴关系的促进者，以实现睡眠研究的可持续发展。该中心提供框架来实现这一使命的具体目标是：（1）提供致力于睡眠相关症状科学的研究基础设施； (2) 扩大参与高质量、创新的跨学科生物行为睡眠研究的研究人员数量； (3) 促进研究项目的可持续发展，尤其是睡眠项目。建议设立两个核心，即管理核心和睡眠测量核心，以实现该中心的目标。可持续性是通过以下方式实现的： (a) 培养转化和临床研究人员的骨干队伍，对他们来说，睡眠是其研究项目的主要重点； (b) 建立足够数量的研究人员，将睡眠作为其研究计划的主要关注变量； (c) 让睡眠障碍是其研究计划的重要组成部分的研究人员参与其中，例如心血管疾病和与治疗相关的睡眠后果。在组织层面，可持续性是通过中心活动的延续和整合到护理学院的组织结构中来实现的。 更广泛的约翰霍普金斯大学社区。

项目成果

The role of positive affect in pain and its treatment.

积极影响在疼痛及其治疗中的作用。

• 发表时间: 2015-02
• 作者: Finan, Patrick H;Garland, Eric L
• 通讯作者: Garland, Eric L

Rheumatoid arthritis: stress affects rheumatoid arthritis, but via what mechanisms?

类风湿性关节炎：压力会影响类风湿性关节炎，但通过什么机制呢？

• 发表时间: 2013-10
• 作者: Finan, Patrick H;Zautra, Alex J
• 通讯作者: Zautra, Alex J

Affective disturbance in rheumatoid arthritis: psychological and disease-related pathways.

类风湿性关节炎的情感障碍：心理和疾病相关途径。

• 发表时间: 2016
• 作者: Sturgeon, John A;Finan, Patrick H;Zautra, Alex J
• 通讯作者: Zautra, Alex J

Pain-related nucleus accumbens function: modulation by reward and sleep disruption.

疼痛相关的伏隔核功能：通过奖赏和睡眠中断进行调节。

• 发表时间: 2019
• 影响因子: 7.4
• 作者: Seminowicz, David A;Remeniuk, Bethany;Krimmel, Samuel R;Smith, Michael T;Barrett, Frederick S;Wulff, Andreas B;Furman, Andrew J;Geuter, Stephan;Lindquist, Martin A;Irwin, Michael R;Finan, Patrick H
• 通讯作者: Finan, Patrick H

Is the brain reward system a mechanism of the association of sleep and pain?

大脑奖励系统是睡眠和疼痛关联的机制吗？

• 发表时间: 2016
• 影响因子: 1.7
• 作者: Finan, Patrick H;Remeniuk, Bethany
• 通讯作者: Remeniuk, Bethany