Building Research Capacity to Study Periodontitis and Associated Systemic Comorbidities in the Caribbean

建设加勒比地区牙周炎及相关系统合并症的研究能力

• 批准号: 10664397
• 负责人: Paul Dean Brown
• 金额: $ 23.31万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664397
• 关键词: Address; Adolescent; Adult; Affect; Basic Science; Behavioral; Bioinformatics; Cardiometabolic Disease; Caribbean region; Child; Chronic; Chronic Disease; Clinical; Collaborations; Data Science; Dental; Dentists; Development Plans; Doctor of Philosophy; Educational Curriculum; Enrollment; Epidemiologist; Epidemiology; Faculty; Fellowship; Foundations; Functional disorder; Future; Health; Immune response; Immunology; Interdisciplinary Study; Intervention; Jamaica; Jamaican; Knowledge; Laboratories; Medical; Medical Faculty; Mentors; Oral; Oral health; Periodontal Diseases; Periodontitis; Postdoctoral Fellow; Research; Research Activity; Research Personnel; School Dentistry; Science; Scientist; Systemic disease; Training; Training Programs; Universities; West Indies; cardiometabolism; clinical training; cohort; comorbidity; experience; faculty mentor; graduate student; human subject; innovation; microbiome; microbiome research; multidisciplinary; next generation; pre-doctoral; programs; research and development; response; social; translational medicine

PROJECT SUMMARY The Faculty of Medical Sciences at the University of the West Indies Mona Campus aims to expand its inter- disciplinary research capacity by developing a training program to study the determinants of periodontitis and associated non-communicable chronic diseases in Jamaica. This program was created in response to the need for research in periodontitis, a highly prevalent non-communicable chronic condition with implications for oral and systemic health, for which there is lack of knowledge with respect to its epidemiology and pathophysiology in the Caribbean region. This program will be focused on expanding the clinical, epidemiology and basic science research capacity at the Department of Basic Medical Sciences and the Mona School of Dentistry in collaboration with The Caribbean Institute for Health Research (CAIHR). The development of this research capacity requires the training of clinical and basic scientists to be mentored by faculty from the University of the West Indies in collaboration with The University at Buffalo and Rush University in the US. Trainees will be degree candidates at the University of the West Indies enrolled in Masters or PhD programs and dental clinicians conducting post- doctoral fellowship training, who will be part of inter-disciplinary teams that will investigate the social, behavioral, microbiome and host response determinants of periodontitis in Jamaican subject cohorts. The specific aims of this application are to 1) Create a core of young investigators (4 pre-doctoral basic scientists or epidemiologists and 4 post-doctoral dentist-scientists) to conduct inter-disciplinary research in periodontal disease and associated comorbidities in Jamaica. 2) Provide a multidisciplinary team-based mentoring approach to conduct innovative research that integrates epidemiology, microbiome science, immunology, translational medicine and data science. 3) Build the foundation to establish large human subject cohorts at the University of the West Indies to study periodontal disease and associated comorbidities, thereby supporting future independent research activities of young faculty who will train the next generation of graduate students and fellows. These objectives will be accomplished through inter-disciplinary teams of mentors and trainees focused on evaluating the pathophysiology of periodontitis in a cohort of children/adolescents and in an adult cohort affected by cardiometabolic systemic disease. Customized curricula based on each trainee’s individualized development plan will be implemented. Trainees will have a short-term (6 months) training experience in US laboratories directed by faculty mentors with extensive experience in epidemiology, periodontology, microbiome, bioinformatics, immunology and cardiometabolic disease, while completing their research degree or postdoctoral programs at the University of the West Indies. This program is expected to provide a rigorous interdisciplinary scientific training experience and create a pool of candidates with potential to join the Faculty at the University of the West Indies. This program will also address a need for oral health research and interventions in Jamaica.

项目摘要 西印度群岛大学莫娜校园的医学科学学院旨在扩大其间 纪律研究能力通过制定培训计划来研究牙周炎和 牙买加相关的非通讯慢性疾病。该程序是根据需求而创建的 对于牙周炎的研究，高度普遍的非交流性慢性病对口腔有影响 和系统健康，在其流行病学和病理生理学方面缺乏知识 在加勒比地区。该计划将侧重于扩展临床，流行病学和基础科学 基础医学科学系和Mona牙科学院的研究能力合作 与加勒比健康研究所（CAIHR）一起。这项研究能力的发展需要 西印度群岛大学的临床和基础科学家培训将由 与美国布法罗大学和拉什大学的大学合作。学员将成为学位候选人 在西印度群岛大学参加硕士或博士学位课程和牙科临床医生 博士学位奖学金培训将成为跨学科团队的一部分，这些团队将研究社会，行为， 微生物组和宿主反应确定牙买加受试者队列中的牙周炎。具体目的 该应用程序是1）创建年轻研究人员的核心（4位博士前基础科学家或流行病学家 和4个博士后牙医科学家）在牙周疾病和 牙买加的相关合并症。 2）提供一种基于多学科的团队心理方法来进行行为 创新研究，该研究整合流行病学，微生物组科学，免疫学，转化医学和 数据科学。 3）建立在西印度群岛建立大型人类学科人群的基础 研究牙周疾病和相关的合并症，从而支持未来的独立研究 年轻教师的活动，他们将培训下一代研究生和研究员。这些目标 将通过专注于评估的导师和学员的跨学科团队来完成 一群儿童/青少年和成年队列中的牙周炎病理生理学 心脏代谢全身性疾病。根据每个学员的个性化发展定制课程 计划将被实施。学员将在美国实验室拥有短期（6个月）的培训经验 由教师导师指导，具有广泛的流行病学，牙周病学，微生物组， 在完成研究学位或博士后，生物信息学，免疫学和心脏代谢疾病 西印度群岛大学的课程。预计该计划将提供严格的跨学科 科学培训经验并创建有可能加入大学教师的候选人 西印度群岛。该计划还将解决牙买加口腔健康研究和干预措施的需求。