Optimizing cochlear implants for music perception

优化人工耳蜗的音乐感知

• 批准号: 10544724
• 负责人: Katelyn Berg
• 金额: $ 7.18万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-29 至 2024-12-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544724
• 关键词: Action Potentials; Address; Adult; Affect; Apical; Auditory; Awareness; Behavioral; Cochlear Implants; Communication; Counseling; Cueing for speech; Cues; Data; Development; Devices; Discrimination; Effectiveness; Electric Stimulation; Electrodes; Faculty; Frequencies; Funding; Future; Goals; Image; Implanted Electrodes; Knowledge; Liquid substance; Manufacturer; Measures; Mediating; Methods; Mirza; Modeling; Music; Neurobiology; Noise; Outcome; Outcomes Research; Participant; Patients; Pattern; Perception; Performance; Pitch Discrimination; Pitch Perception; Psychophysics; Quality of life; Research; Research Personnel; Rest; Sensorineural Hearing Loss; Speech; Speech Acoustics; Statistical Data Interpretation; Stimulus; Techniques; Testing; Training Programs; United States National Institutes of Health; Universities; Width; Work; design; evidence based guidelines; experimental study; implantation; improved; instrument; interest; member; neural; noise perception; novel strategies; open data; signal processing; simulation; skills; sound; speech in noise; speech recognition; standard care; tenure track

PROJECT SUMMARY / ABSTRACT Cochlear implants (CIs) are the standard treatment for adults with moderate sloping to profound sensorineural hearing loss and enable sound awareness and spoken communication to a high majority of recipients. However, CI outcomes that rely on high-fidelity spectral encoding, such as music perception and speech understanding in noise, remain highly variable. One of the biggest contributors to this variability is channel interaction, but the relationship between spectral-dependent tasks (i.e., pitch, melody, timbre, and speech in noise perception) and channel interaction is not clearly defined. This study aims to manipulate channel interaction via spectral blurring in adult CI recipients to directly measure the effects of channel interaction on spectral-dependent tasks. We will also explore the use of image-based electrode selection as an approach for reducing channel interaction and its impact on music perception. Given that our preliminary data suggest a relationship between electrode placement and psychophysical pitch discrimination, we hypothesize that there will be a negative relationship between channel interaction and music perception outcomes. This hypothesis will be tested using a newly developed method of manipulating the excitation patterns of stimulation directly in CI recipients to investigate the causal relationship between channel interaction and outcomes. This model is advantageous over previous methods because it accounts for the effects of electrical stimulation, neural excitation, and sensorineural hearing loss present in actual CI-mediated listening. Primary Aim 1 will characterize the effects of channel interaction and the impact of spread of excitation (SOE) and electrode placement on pitch discrimination in all participants. Exploratory Aim 2 will measure the degree of image-based electrode selection benefit for CI-mediated pitch discrimination in a subset of participants. Collectively, these data will quantify channel interaction effects directly in CI recipients and provide a model to enable more detailed studies targeting potential uses of image-based electrode selection to improve CI-mediated listening. More broadly, this research should help improve signal processing methods for how stimuli, such as music and speech in noise, are encoded in CI stimulation, and lead to increased utilization of CIs by addressing CI recipient-driven concerns for variable outcomes. The training program will result in the development of knowledge and skills in: 1) auditory neurobiology and the consequences of sensorineural hearing loss, 2) CI signal processing and its limitations, 3) administering behavioral tasks of music perception to CI recipients, and 4) programming and administering direct stimulation experiments. It will also improve essential skills in grantspersonship, professional development, statistical analyses, and open science practices. Each of these skills is critical to achieving the applicant's goal of becoming a tenure-track faculty member at a research- intensive university with an independent line of NIH-funded CI outcomes research.

项目摘要 /摘要 人工耳蜗植入物（CIS）是对中等倾斜到深刻感觉的成年人的标准治疗方法 听力损失和使声音意识和与大多数接收者的交流。 但是，依赖高保真光谱编码的CI结果，例如音乐感知和语音 理解噪声，保持高度可变。这种可变性的最大因素之一是渠道 相互作用，但是与光谱依赖性任务之间的关系（即音调，旋律，音色和语音 噪声感知）和通道相互作用尚未明确定义。这项研究旨在操纵渠道 通过在成年CI受体中模糊的光谱相互作用，直接测量通道相互作用的影响 依赖光谱的任务。我们还将探讨基于图像的电极选择作为一种方法 减少频道互动及其对音乐感知的影响。鉴于我们的初步数据表明 电极放置与心理物理音调歧视之间的关系，我们假设那里 将是频道互动与音乐感知结果之间的负相关关系。这个假设 将使用新开发的方法来操纵刺激模式的新方法进行测试 CI接受者研究通道相互作用与结果之间的因果关系。这个模型是 比以前的方法有利，因为它解释了电刺激的影响 实际CI介导的听力中存在激发和感觉性听力损失。主要目标1将 表征通道相互作用的影响以及激发（SOE）和电极的传播影响 在所有参与者中放置在音高歧视上。探索目标2将衡量基于图像的程度 在参与者子集中，CI介导的音高歧视的电极选择益处。总的来说，这些 数据将直接在CI接收者中量化通道交互作用，并提供模型以启用更多 详细研究针对基于图像的电极选择的潜在用途以改善CI介导的聆听。 从更广泛的角度来看，这项研究应有助于改善信号处理方法，以了解音乐和音乐等刺激 噪声中的语音在CI刺激中编码，并通过解决CI导致CI的利用率增加 接收者驱动的可变结果的关注。培训计划将导致 知识和技能：1）听觉神经生物学和感觉性听力损失的后果，2）CI 信号处理及其局限 4）编程和管理直接刺激实验。它还将提高基本技能 奉献精神，专业发展，统计分析和开放科学实践。每个 技能对于实现申请人的目标至关重要 具有独立的NIH资助的CI成果研究的密集大学。