Leadership Administrative Core

领导行政核心

基本信息

批准号：
10540780
负责人：
JILL M GOLDSTEIN
金额：
$ 14.51万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540780
关键词：
Animal Model Animals Biological Biological Models Budgets Cardiovascular Diseases Centers of Research Excellence Clinical Clinical Investigator Clinical Medicine Clinical Research Collaborations Communities Consultations Country Discipline Disease Early Intervention Educational workshop Elderly Electronic Mail Endocrinology Evaluation Expenditure Fetal Development Functional disorder Funding Future Genetic Goals Heart Diseases Hormones Human Immune Immune response Immunology Infrastructure Institution Interdisciplinary Study Knowledge Leadership Life Locales Major Depressive Disorder Medical Mental Depression Metabolic Diseases Methodology Methods Mission Modeling Monitor Moods Neurology Neurosciences Pathway interactions Peripheral Physiological Policy Maker Population Psychiatry Public Health Publications Radiology Specialty Recurrence Reporting Resources Risk Schedule Scientist Series Sex Differences Site Specialized Center Stress Technology Telephone Therapeutic Thinking Time Training Translating Translational Research United States National Institutes of Health Woman Work brain circuitry career disability disorder risk high risk meetings middle age mortality risk neural circuit neurovascular next generation novel novel strategies prenatal stress sex specific biomarkers symposium synergism tool translational study web site

项目摘要

LAC SUMMARY The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic function and translate this knowledge into sex-selective therapeutics. Further, we aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD and autonomic dysregulation to the scientific and medical communities, policy makers, and the public. To accomplish our aims in three projects and three cores, we are proposing a series of interdisciplinary and translational studies from basic and clinical neuroscience and population-level perspectives, integrating scientists from different disciplines and institutions ranging from the lab bench to the clinical level. In the Resource Support Core (RSC), we are integrating and introducing novel state-of-the-art technologies, with some that will cross human and animal work. In the Career Enhancement Core (CEC), educating young scientists in new approaches and insuring that their future work will translate sex as a biologic variable into their (and others') thinking in clinical medicine. The Leadership Administrative Core (LAC) is essential in providing an infrastructure to monitor, integrate, and synergize ongoing activities. The specific aims of the LAC are to: Coordinate activities of the SCORE; Administer budgets, insuring financial responsibility and coordination across sites and activities; and Disseminate knowledge through online tools, organizing symposia and workshops and other avenues to connect the SCORE with the medical community, policy makers, NIH, and the public.

LAC摘要该分数的科学任务是识别胎儿的压力免疫途径异常开发，对调节情绪和终生的大脑电路的性别差异有分享的后果复发性MDD和激素的失调和对压力的免疫反应以及自主神经和免疫反应中年早期神经血管功能障碍。我们旨在促进跨学科的翻译合作在基本和临床研究人员中，以增强我们对性别对MDD和中央的影响的理解以及外围自主神经功能，并将这些知识转化为性选择性疗法。此外，我们旨在作为训练和传播有关MDD性别差异发现的跨学科资源以及对科学和医疗社区，政策制定者和公众的自主性失调。为了在三个项目和三个核心中实现目标，我们提出了一系列跨学科和从基本和临床神经科学以及人群水平的观点进行的翻译研究，整合来自不同学科和机构的科学家从实验室基准台到临床水平。在资源支持核心（RSC），我们正在将新颖的最新技术集成和介绍有些会跨越人类和动物的工作。在职业增强核心（CEC）中，教育Young 新方法的科学家并确保他们的未来工作将把性转化为生物学变量他们（和其他人）在临床医学方面的思考。领导行政核心（LAC）在提供一个基础架构来监视，集成和协同持续的活动。 LAC的具体目的是：协调分数的活动；管理预算，确保财务责任和跨站点和活动的协调；并通过在线工具传播知识，组织研讨会以及与医学界，政策制定者NIH，NIH的分数联系的研讨会和其他途径和公众。