Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research Collaborative

美国国立卫生研究院精准健康营养临床中心：我们所有人新英格兰研究合作组织

• 批准号: 10539337
• 负责人: Sai Krupa Das
• 金额: $ 189.89万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-10 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10539337
• 关键词: Address; Adherence; Adult; Adverse event; Aging; Algorithms; All of Us Research Program; Behavioral; Chronic Disease; Clinical; Cognitive; Collaborations; Community Outreach; Community Participation; Core Facility; Coupled; Cross-Over Studies; DASH diet; Data; Development; Diet; Dietary Formulations; Dietary Intervention; Dietary Practices; Dietary intake; Discipline of Nursing; Domiciles; Enrollment; Ensure; Environmental Risk Factor; Food; Formulation; Funding; General Hospitals; Genomics; Goals; Health; Human; Individual; Individual Differences; Inpatients; Longevity; Massachusetts; Measures; Metabolic; Metagenomics; Methods; Modeling; Movement; New England; Non-Insulin-Dependent Diabetes Mellitus; Nutritional Study; Oral; Outcome; Outcome Assessment; Participant; Patient Recruitments; Phase; Physiological; Population; Positioning Attribute; Precision Health; Productivity; Protocols documentation; Public Health; Randomized; Recommendation; Records; Research; Resources; Risk Reduction; Science; Site; Standardization; Surveys; System; Testing; Thinking; Translational Research; United States Department of Agriculture; United States National Institutes of Health; Universities; Variant; Visit; algorithm development; biobank; clinical center; clinical research site; clinical translation; cohort; contextual factors; dietary; dietary adherence; dietary control; doubly-labeled water; eHealth; experience; feeding; flexibility; individual response; individual variation; inter-individual variation; ketogenic diet; metabolomics; microbiome; new technology; non-compliance; novel; nutrition; participant retention; personalized approach; population based; precision nutrition; prediction algorithm; programs; recruit; response; skills; tool; volunteer

PROJECT SUMMARY The All of Us New England Clinical Center (AoU-NE-CC) is a collaboration of New England–based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund’s Nutrition for Precision Health (NPH) Clinical Center program. The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts- HNRCA) and Massachusetts General Hospital (MGH) will lead the AoU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns. The AoU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AoU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions. Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health. To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet. We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility. With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AoU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH. Additional strengths of the AoU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health. Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals. By partnering with NPH and All of Us in this novel modular discovery science study, the AoU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.

项目摘要 我们所有人的新英格兰临床中心（Aou-ne-CC）都是基于新英格兰的研究的合作 具有营养和临床转化科学领域必要的专业知识和资源的团队来实施 成功地成功地，NIH Common基金的Precision Health营养（NPH）临床中心的所有3个模块 程序。塔夫茨大学（Tufts- Jean Mayer USDA人类营养研究中心） HNRCA）和马萨诸塞州综合医院（MGH）将领导Aou-ne-CC和我们所有人的合作伙伴 英格兰确保参与者的多样性和识别个体间变异所需的科学严谨性 对饮食模式的反应。 Aou-ne-CC致力于我们所有的核心价值观，并已实施 团队科学的最佳实践整个发展。 AOU-NE-CC将作为关键合作伙伴 开发严格的NPH共同方案和考试习惯性饮食摄入量（模块1），测量 对混合粉碎挑战（模块1-3）的物理反应，并确定对3干预的反应 自由生活（模块2）和区域（模块3）受控喂养条件的饮食。加上 我们所有的数据数据，通过这些模块收集的物理响应将用于开发 预测算法为长期健康提供了精确营养方法。达到最大 代谢组和微生物组响应变异性，我们提出了以下14天的等饮食模块2 3，以4周的冲洗期分开：（1）一种高粘性饮食方法来阻止高血压 （破折号）饮食； （2）低遵守破折号饮食； （3）生酮饮食。我们还建议使用 经过彻底测试的混合挑战phenflex，可以在临床中心进行标准化 提供代谢灵活性的多系统评估。具有出色的核心设施，包括 代谢厨房和住所喂养和护士中心，以及严格的富裕遗产 喂养研究，Aou-ne-CC具有独特的技能，并且可以作为NPH的临床中心。 Aou-ne-CC的其他优势包括招募临床人群和 生物群，通过社区外展活动吸引志愿者，积极参与全球精确营养 倡议，以及营养，omics和Omics和 精度健康。重要的是，Tufts-HNRCA和MGH团队与我们所有人的新成员都紧密合作 英格兰队及其高度参与招募和保留及其潜水队的记录，这将 支持NPH联盟目标。通过与NPH和我们所有人合作在这一新颖的模块化发现中 科学研究，Aou-ne-CC及其经验丰富，有思想，高度协作的团队将为 开发精确营养方法，以支持整个成人寿命的最佳健康。