Studies in Translational Regenerative Medicine

转化再生医学研究

• 批准号: 10663320
• 负责人: ANTHONY ATALA
• 金额: $ 16.55万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2025-06-23
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663320
• 关键词: Regenerative Medicine

Project Summary/Abstract The Regenerative Medicine (RM) field requires a new type of researcher, well-trained in fundamental RM concepts and methods, able to integrate human biology and engineered systems with awareness of challenges involved in advancing basic research, regulatory science, and clinical translation. The overall goal of our T32 pre-doctoral training program, “Studies in Translational Regenerative Medicine”, remains committed to developing next generation multidisciplinary trained research scientists and engineers, who will lead new diverse research teams designing solutions to real-world health problems and advance the RM field. Ability to link state-of-the-art multidisciplinary basic science training to the infrastructure and knowledge base required to accelerate translation of RM technologies are key strengths. To date, this T32 program has provided 10 PhD trainees the tools to become independent RM researchers. Consistent with faculty's successful record of educating pre-, post-doctoral and early-career faculty, the first cycle of our T32 program exceeded goals. Trainees accrued an impressive list of quality publications (66 published/14 in process) and oral and poster presentations (103) at local, national and international meetings. Importantly, 100% of appointed trainees are currently working on their PhD requirements or have obtained their PhD degrees. Six trainees completed their T32 training and PhD defense and successfully moved on to academic or non- academic careers. Of these, 4 (66%) remain in explicitly focused RM research. Three (50%) were recruited, because of their T32 training, into industry positions with extensive RM portfolios. WFIRM's distinctive infrastructure provides the facilities and expertise for translational studies ranging from basic preclinical studies through Phase 2 clinical trials. WFIRM's multidisciplinary training includes a range of activities, including didactic courses, participation in cutting-edge team science, and new opportunities to engage in academic, government, and industrial externships. The new program emphasizes professional and career development, including project and time management, grant writing, regulatory science, GMP manufacturing, and scientific ethics. The program has 3 NIBIB-aligned focus areas: 1) biomaterials; 2) enabling technologies (bioprinting, body-on-a-chip, imaging & multifluidics); and 3) stem cells/cell therapies applied to one or more application areas: 1) cardiovascular; 2) musculoskeletal; 3) gastrointestinal/endocrinal; and 4) urological. Trainees are selected from 4 of 7 WFGS tracks: Biomedical Engineering, Molecular & Cellular Biosciences, Neuroscience or Integrative Physiology and Pharmacology. After a common 1st year curriculum (unique to each track), trainees identify one of 10 primary mentors (of 19 mentoring faculty), take specialized RM courses and choose a graduate committee. Inclusion of seasoned Primary Mentors (10), Mentors-in-Training (6), and Emeritus Mentors (3) with career-long mentoring experience is a unique program aspect. The program is reviewed by Internal and External Advisory Boards composed of prominent academic, government, and industry members.

项目摘要/摘要 再生医学（RM）领域需要一种新型的研究人员，训练有素的RM 概念和方法，能够将人类生物学和工程系统整合到认识到挑战 参与进步基础研究，法规科学和临床翻译。我们T32的总体目标 博士前培训计划，“转化再生医学研究”，仍然致力于 发展下一代多学科训练的研究科学家和工程师，他们将领导 新的潜水员研究团队设计解决现实健康问题的解决方案并提高RM 场地。能够将最先进的多学科基础科学培训与基础设施和知识联系起来的能力 加速RM技术所需的基础是关键优势。迄今为止，此T32程序具有 向10位学员提供了成为独立RM研究人员的工具。与教师的一致 成功教育前，博士后和早期职业教师的成功记录，这是我们T32计划的第一个周期 超出目标。受训人员累积了令人印象深刻的优质出版物清单（在流程中已发布/14个）和 本地，国家和国际会议上的口头和海报演讲（103）。重要的是，100％ 任命的学员目前正在研究其博士学位要求或已获得博士学位。六 学员完成了T32培训和博士辩护，并成功地转向了学术或非 - 学术职业。其中，有4个（66％）仍在明确的重点RM研究中。招募了三个（50％）， 由于他们进行了T32培训，并以广泛的RM投资组合为行业职位。 Wfirm的独特之处 基础设施为转化研究提供了从基本临床前研究的设施和专业知识 通过2阶段临床试验。 WFIRM的多学科培训包括一系列活动，包括 教学课程，参与尖端团队科学以及从事学术的新机会 政府和工业外部工作。新计划强调专业和职业发展， 包括项目和时间管理，赠款写作，监管科学，GMP制造和科学 伦理。该计划具有3个与尼比布一致的重点领域：1）生物材料； 2）启用技术（生物打印， 片，成像和多流体学）; 3）应用于一种或多个应用的​​干细胞/细胞疗法 区域：1）心血管； 2）肌肉骨骼； 3）胃肠道/内分泌； 4）泌尿外科。学员是 从7个WFGS轨道中的4个中选择：生物医学工程，分子和细胞生物科学，神经科学或 综合生理学和药理学。经过一年级的第一年课程（每条轨道独有），培训 确定10位主要导师之一（19个心理教师），参加专门的RM课程，然后选择一个 研究生委员会。包括经验丰富的主要导师（10），训练导师（6）和名誉 具有职业心理经验的导师（3）是一个独特的计划方面。该程序由 内部和外部咨询委员会由著名的学术，政府和行业成员组成。

项目成果

Tenocyte cell density, migration, and extracellular matrix deposition with amniotic suspension allograft.

• DOI: 10.1002/jor.24173
• 发表时间: 2019-03
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Kimmerling KA;McQuilling JP;Staples MC;Mowry KC
• 通讯作者: Mowry KC

Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments.

• DOI: 10.1002/sctm.17-0157
• 发表时间: 2018-03
• 期刊: Stem cells translational medicine
• 影响因子: 6
• 作者: Mokhtari S;Baptista PM;Vyas DA;Freeman CJ;Moran E;Brovold M;Llamazares GA;Lamar Z;Porada CD;Soker S;Almeida-Porada G
• 通讯作者: Almeida-Porada G

Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes.

羊膜和绒毛膜的蛋白质组比较以及处理对胎盘膜的影响的评估。

• 发表时间: 2017
• 期刊: Wounds : a compendium of clinical research and practice
• 作者: McQuilling,JohnP;Vines,JeremyB;Kimmerling,KellyA;Mowry,KatieC
• 通讯作者: Mowry,KatieC

Dehydrated Amnion/Chorion Improves Achilles Tendon Repair in a Diabetic Animal Model.

脱水羊膜/绒毛膜可改善糖尿病动物模型中的跟腱修复。

• 发表时间: 2019
• 期刊: Wounds : a compendium of clinical research and practice
• 作者: McQuilling,JohnP;Sanders,Mitchell;Poland,Lindsay;Sanders,Mia;Basadonna,Giacomo;Waldrop,NormanE;Mowry,KatieC
• 通讯作者: Mowry,KatieC

N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury.

• DOI: 10.1093/milmed/usz232
• 发表时间: 2020-01
• 期刊: Military medicine
• 影响因子: 1.2
• 作者: Benyam Yosef;Yu Zhou;Kathryn Mouschouris;J. Poteracki;S. Soker;T. Criswell