Studies in Translational Regenerative Medicine

转化再生医学研究

• 批准号: 10663320
• 负责人: ANTHONY ATALA
• 金额: $ 16.55万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2025-06-23
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663320
• 关键词: Regenerative Medicine

Project Summary/Abstract The Regenerative Medicine (RM) field requires a new type of researcher, well-trained in fundamental RM concepts and methods, able to integrate human biology and engineered systems with awareness of challenges involved in advancing basic research, regulatory science, and clinical translation. The overall goal of our T32 pre-doctoral training program, “Studies in Translational Regenerative Medicine”, remains committed to developing next generation multidisciplinary trained research scientists and engineers, who will lead new diverse research teams designing solutions to real-world health problems and advance the RM field. Ability to link state-of-the-art multidisciplinary basic science training to the infrastructure and knowledge base required to accelerate translation of RM technologies are key strengths. To date, this T32 program has provided 10 PhD trainees the tools to become independent RM researchers. Consistent with faculty's successful record of educating pre-, post-doctoral and early-career faculty, the first cycle of our T32 program exceeded goals. Trainees accrued an impressive list of quality publications (66 published/14 in process) and oral and poster presentations (103) at local, national and international meetings. Importantly, 100% of appointed trainees are currently working on their PhD requirements or have obtained their PhD degrees. Six trainees completed their T32 training and PhD defense and successfully moved on to academic or non- academic careers. Of these, 4 (66%) remain in explicitly focused RM research. Three (50%) were recruited, because of their T32 training, into industry positions with extensive RM portfolios. WFIRM's distinctive infrastructure provides the facilities and expertise for translational studies ranging from basic preclinical studies through Phase 2 clinical trials. WFIRM's multidisciplinary training includes a range of activities, including didactic courses, participation in cutting-edge team science, and new opportunities to engage in academic, government, and industrial externships. The new program emphasizes professional and career development, including project and time management, grant writing, regulatory science, GMP manufacturing, and scientific ethics. The program has 3 NIBIB-aligned focus areas: 1) biomaterials; 2) enabling technologies (bioprinting, body-on-a-chip, imaging & multifluidics); and 3) stem cells/cell therapies applied to one or more application areas: 1) cardiovascular; 2) musculoskeletal; 3) gastrointestinal/endocrinal; and 4) urological. Trainees are selected from 4 of 7 WFGS tracks: Biomedical Engineering, Molecular & Cellular Biosciences, Neuroscience or Integrative Physiology and Pharmacology. After a common 1st year curriculum (unique to each track), trainees identify one of 10 primary mentors (of 19 mentoring faculty), take specialized RM courses and choose a graduate committee. Inclusion of seasoned Primary Mentors (10), Mentors-in-Training (6), and Emeritus Mentors (3) with career-long mentoring experience is a unique program aspect. The program is reviewed by Internal and External Advisory Boards composed of prominent academic, government, and industry members.

项目概要/摘要 再生医学 (RM) 领域需要新型研究人员，接受过基础 RM 方面的良好培训 概念和方法，能够将人类生物学和工程系统结合起来，并具有挑战意识 参与推进基础研究、监管科学和临床转化 我们 T32 的总体目标。 博士前培训项目“转化再生医学研究”仍然致力于 培养下一代经过多学科训练的研究科学家和工程师，他们将领导 新的多元化研究团队为现实世界的健康问题设计解决方案并推进 RM 能够将最先进的多学科基础科学培训与基础设施和知识联系起来。 迄今为止，T32 计划已具备加速 RM 技术转化所需的基础。 为 10 名博士生提供了成为独立 RM 研究人员的工具，与教师的要求一致。 我们 T32 项目的第一个周期，在教育学前、博士后和早期职业教师方面取得了成功 超出了目标。受训者积累了一系列令人印象深刻的高质量出版物（66 种已出版/14 种正在处理）并且 重要的是，在地方、国家和国际会议上进行口头和海报展示 (103)。 指定的学员目前正在攻读博士学位要求或已获得博士学位。 学员完成了 T32 培训和博士答辩，并成功进入学术或非学术领域 其中，4 名（66%）仍从事明确的 RM 研究，3 名（50%）被招募。 由于他们接受过 T32 培训，因此能够进入具有广泛 WFIRM 独特产品组合的行业职位。 基础设施为从基础临床前研究到转化研究提供设施和专业知识 通过 2 期临床试验，WFIRM 的多学科培训包括一系列活动，包括 教学课程、参与尖端团队科学以及从事学术、 新计划强调专业和职业发展， 包括项目和时间管理、拨款写作、监管科学、GMP 制造和科学 该计划有 3 个与 NIBIB 一致的重点领域：1）生物材料；2）支持技术（生物打印、 片上体、成像和多流体）；以及 3）应用于一种或多种应用的干细胞/细胞疗法 领域：1) 心血管；2) 肌肉骨骼；3) 胃肠/内分泌；4) 泌尿科。 从 7 个 WFGS 方向中的 4 个中选择：生物医学工程、分子和细胞生物科学、神经科学或 综合生理学和药理学后，学员完成第一年的共同课程（每个课程都是独特的）。 确定 10 位主要导师（19 位导师）中的一位，参加专门的 RM 课程并选择一个 研究生委员会包括经验丰富的主要导师 (10)、培训导师 (6) 和荣誉退休人员 具有职业生涯指导经验的导师 (3) 是该计划的一个独特方面。 由著名学术界、政府和行业成员组成的内部和外部顾问委员会。

项目成果

Tenocyte cell density, migration, and extracellular matrix deposition with amniotic suspension allograft.

• DOI: 10.1002/jor.24173
• 发表时间: 2019-03
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Kimmerling KA;McQuilling JP;Staples MC;Mowry KC
• 通讯作者: Mowry KC

Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments.

• DOI: 10.1002/sctm.17-0157
• 发表时间: 2018-03
• 期刊: Stem cells translational medicine
• 影响因子: 6
• 作者: Mokhtari S;Baptista PM;Vyas DA;Freeman CJ;Moran E;Brovold M;Llamazares GA;Lamar Z;Porada CD;Soker S;Almeida-Porada G
• 通讯作者: Almeida-Porada G

Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes.

羊膜和绒毛膜的蛋白质组比较以及处理对胎盘膜的影响的评估。

• 发表时间: 2017
• 期刊: Wounds : a compendium of clinical research and practice
• 作者: McQuilling,JohnP;Vines,JeremyB;Kimmerling,KellyA;Mowry,KatieC
• 通讯作者: Mowry,KatieC

Dehydrated Amnion/Chorion Improves Achilles Tendon Repair in a Diabetic Animal Model.

脱水羊膜/绒毛膜可改善糖尿病动物模型中的跟腱修复。

• 发表时间: 2019
• 期刊: Wounds : a compendium of clinical research and practice
• 作者: McQuilling,JohnP;Sanders,Mitchell;Poland,Lindsay;Sanders,Mia;Basadonna,Giacomo;Waldrop,NormanE;Mowry,KatieC
• 通讯作者: Mowry,KatieC

N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury.

• DOI: 10.1093/milmed/usz232
• 发表时间: 2020-01
• 期刊: Military medicine
• 影响因子: 1.2
• 作者: Benyam Yosef;Yu Zhou;Kathryn Mouschouris;J. Poteracki;S. Soker;T. Criswell