Center for Harmonizing and Improving Interventions to Prevent Suicide (CHIIPS)

协调和改进预防自杀干预措施中心 (CHIIPS)

• 批准号: 10662785
• 负责人: Marianne Goodman
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662785
• 关键词: Address; Adult; Advisory Committees; Assessment tool; Biological Markers; Characteristics; Clinical; Clinical Trials; Collaborations; Communities; Complement; Consultations; Data; Data Analyses; Death Rate; Development; Disparity; Education; Effectiveness; Faculty; Fellowship; Funding; Funding Mechanisms; Goals; Grant Review; Growth; Guidelines; Individual; Infrastructure; Intervention; Leadership; Mentors; Mentorship; Methodology; Methods; Mission; Monitor; Outcome; Patients; Pilot Projects; Population; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Predictive Analytics; Prevention Research; Protocols documentation; Publishing; Qualifying; Recommendation; Research; Research Design; Research Personnel; Resources; Review Literature; Risk; Role; Safety; Science; Services; Standardization; Suicide; Suicide attempt; Suicide prevention; System; Time; Training; Training Programs; Training and Education; Veterans; Vision; Vulnerable Populations; Work; career; comparative effectiveness study; data repository; education resources; experience; improved; innovation; member; next generation; precision medicine; preventive intervention; reducing suicide; research and development; research facility; response; screening; secondary analysis; service member; social determinants; success; suicidal individual; suicidal morbidity; suicidal risk; suicide mortality; suicide rate; synergism; therapy development; timeline; tool; treatment planning

Background: The rate of death by suicide has risen by more than 30% in the past 20 years in the U.S. The rate of death by suicide among U.S. Veterans has risen even faster. Whereas Veterans only constitute 8.5% of the population, they account for 18% of all suicide deaths among U.S. adults. Although recent declines in suicide mortality among Veterans may be cause for some hopefulness, they also obscure the dynamics of suicide mortality and effectiveness of preventive interventions across vulnerable groups. Further, although we do have methods available to stratify individuals by risk level and interventions that can have positive effects in terms of reducing suicide attempts, these tools are far from perfect. There is still an urgent need to determine which available suicide prevention interventions might be the most effective for a given individual at a given time. Significance: The proposed suicide prevention clinical resource center (SP-CRC) is responsive to CSRD’s solicitation of applications from VA research facilities to establish an SP-CRC that will serve suicide prevention investigators by providing highly critical research resources to facilitate programmatic and scientific needs. The mission of our SP-CRC, the Center for Harmonizing and Improving Interventions to Prevent Suicide (CHIIPS), will be to advance a precision medicine approach to suicide prevention research. CHIIPS content area hubs will include Predictive Analytics, Biomarkers, Identification, Screening, Assessment, Social Determinants/Disparities, Interventions, and (v) Training and Education Innovation and Impact: By establishing a VA SP-CRC with an explicit focus on promoting precision medicine for suicide prevention, we will improve individual suicide prevention outcomes, address unsatisfactory response rates for standardized treatments, promote the incorporation of diverse patient presentations, characteristics, and needs into treatment plans and suicide prevention research, improve system and population-level outcomes, and increase efficient use of finite resources (staff, funds, infrastructure). Resources Delivered: At the completion of this project, we will have provided several resources to the VA suicide prevention research community including: 1) a portfolio review of VA suicide prevention research portfolio projects on precision medicine, 2) a dataset repository for use by VA suicide prevention researchers to conduct secondary analyses, 3) the establishment of precision medicine suicide prevention research postdoctoral fellowships, 4) creation and dissemination of several recommendations for clinical trials methodology and safety protocols for suicide prevention research, 5) various precision medicine related educational resources for suicide prevention researchers to promote competent precision medicine suicide prevention research, 6) a statistical and research design consultation service, 7) funding for precision medicine suicide prevention pilot studies or supplemental funding for ongoing studies, 8) a literature review of all precision medicine suicide prevention research to date. Coordination with SPRINT: CHIIPS will work closely with the Suicide Prevention Research Impact Network (SPRINT) PIs and hubs to optimize synergies and avoid duplication of effort between the two centers. Our goal is to enhance current SPRINT activities, by leveraging their network and infrastructure to focus on precision medicine approaches. Together, SPRINT and CHIIPS will help VA Office of Research and Development create a vision and set priorities for as well as build a precision medicine suicide prevention research portfolio that will advance the state of the science and help VA achieve its mission of significantly reducing the number of Veteran suicides.

背景：在过去20年中，自杀率上升了30％以上 美国退伍军人自杀的死亡率甚至更快。退伍军人仅占8.5％ 人口占美国成年人所有自杀死亡的18％​​。虽然最近下降了 退伍军人之间的自杀死亡率可能是有希望的，他们也掩盖了动态 弱势群体的预防干预措施的自杀死亡率和有效性。此外，尽管我们 确实有可用的方法来按风险水平和干预措施进行分层，这些方法可能会产生积极影响 减少自杀尝试的条款，这些工具远非完美。仍然需要确定 哪些可用的自杀预防干预措施可能对给定的人最有效 时间。意义：拟议的预防自杀临床资源中心（SP-CRC）对 CSRD从VA研究设施中征集申请，以建立将自杀的SP-CRC 通过提供高度关键的研究资源来促进程序化和科学，预防研究人员 需要。我们的SP-CRC的使命，即协调和改进干预措施的中心以防止 自杀（Chiips）将是一种预防自杀性研究的精确医学方法。 chiips 内容区域中心将包括预测分析，生物标志物，标识，筛选，评估，社会 决定因素/差异，干预措施以及（v）培训和教育创新和影响： 建立一个明确专注于促进预防自杀的精密医学的VA SP-CRC，我们 将改善单个自杀预防结果，解决标准化的不满意的响应率 治疗，促进潜水员的患者演示，特征和需求纳入 治疗计划和预防自杀研究，改善系统和人口水平的结果并增加 有效利用有限资源（员工，资金，基础设施）。交付的资源：完成后 项目，我们将为VA自杀预防研究社区提供几种资源，包括：1） VA自杀预防研究组合项目的投资组合评论，有关精密医学的项目，2）数据集 VA自杀预防研究人员使用次要分析的存储库，3）机构 精密医学预防自杀研究博士后研究金，4）创造和传播 关于自杀预防研究的临床试验方法和安全协议的几项建议， 5）各种精密医学相关的预防自杀研究人员促进的教育资源 有能力的精确医学预防自杀研究，6）统计和研究设计咨询 服务，7）用于精密医学预防自杀试点研究或持续资金的资金 研究，8）迄今为止所有精密医学自杀预防研究的文献回顾。与 Sprint：Chiips将与自杀预防研究影响网络（Sprint）PIS紧密合作 集线器以优化协同作用，并避免在两个中心之间重复努力。我们的目标是增强 当前的冲刺活动，利用其网络和基础设施专注于精密医学 方法。 Sprint和Chiips将共同帮助VA研发办公室创造愿景 并设定优先事项，并建立精密医学自杀预防研究组合 提高科学状态，并帮助VA实现大量减少数量的使命 退伍军人自杀。