Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs

神经急症治疗试验 (NETT) 网络临床站点中心

• 批准号: 8852196
• 负责人: Robert D. Welch
• 金额: $ 29.03万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8852196
• 关键词: Accident and Emergency department; Acute; Address; Adult; American; Area; Budgets; Cardiac; Cerebrum; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Communities; Competence; Computerized Medical Record; Conduct Clinical Trials; Consultations; Critical Care; Critical Illness; Data; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency department visit; Emergency treatment; Enrollment; Evaluation; Evaluation Studies; Family; Future; Goals; Health; Hospitals; Hour; Injury; Institutes; Institution; Intervention Trial; Interventional radiology; Knowledge; Link; Medical center; Michigan; Minority; Monitor; Multi-Institutional Clinical Trial; Neurologic; Neurological emergencies; Neurologist; Neurology; Neurosciences; Neurosurgeon; Operative Surgical Procedures; Outcome; Oxygen saturation measurement; Patient Care; Patients; Pattern; Phase; Physicians; Pre-hospital setting; Pre-hospitalization care; Principal Investigator; Process; Protocols documentation; Public Health; Quality of life; Recording of previous events; Rehabilitation therapy; Relative (related person); Research; Research Infrastructure; Research Personnel; Resuscitation; Schedule; Site; Societies; Specialist; Status Epilepticus; Study Subject; Surgeon; System; Telemedicine; Testing; Training; Trauma; Uncertainty; United States; Universities; Work; base; bench to bedside; care systems; clinical research site; community consultation; data management; demographics; design; effective therapy; expectation; experience; improved; interdisciplinary collaboration; medical specialties; nervous system disorder; neurosurgery; patient population; programs; research study; success; treatment trial

DESCRIPTION (provided by applicant): Acute neurologic disorders, relative to their effect on society, have been very poorly studied. Many of these neurological problems require emergent evaluation and treatment, ideally by a multi-disciplinary team. The NETT network has been established to address just these issues as the discovery and implementation of effective treatments for neurological emergencies will require sophisticated study protocols derived from large-scale clinical trials. The success of this initiative hinges not only on a well-coordinated central data management center, but also on hub and spoke sites that have the competence to enroll patients emergently across a large demographic. The broad and long-term goal of this program is to test and institute new effective therapies for neurological emergencies and improve the overall health of Americans. The project design is that of a central coordinating "Hub" (Dept. of Emergency Medicine, Wayne State University - WSU) which has proven expertise in emergency patient care and emergency based clinical trails. The "Spokes" (Detroit Medical Center and William Beaumont Hospitals) offers: i) expertise in the neurosciences from the bench to the bedside, 2) proven competency in enrolling patients into emergent interventional trials, 3) over 500,000 emergency department visits across a wide demographic that blankets Southeast Michigan and 4) a long history of inter-hospital, interdepartmental and interdisciplinary collaboration. Dr Robert Welch, in conjunction with Dr. Brian O'Neil, has an enviable group of established collaborators that include both adult and pediatric emergency medicine physicians, neurologists, neurosurgeons, critical care specialists and trauma surgeons. The WSU "Hub" has a breadth of experience in emergent intervention trials initiated pre-hospital and continued throughout the emergency department, hospital and rehabilitation phases. WSU investigators have successfully enrolled patient in the pre-hospital interventional trials Res-Q, PAD, PolyHeme, DCAR, POST and Cerebral oximetry trials. Furthermore the same investigators have been leaders in enrolled patients in various emergent interventional trials such as RESCUE, TIA-ADP, PECARN, ONO-REACT, BADHIT, Gen-IMS, PROACTION, and RESCUE-ACS. In each of these trials our sites have exceeded expectations and provided high volume and high quality clean data to the principal investigators. A number of these studies required community consultation for implementation. The WSU site is equipped with an integrated and sophisticated electronic medical record system that links hospital sites. The system has advanced telemedicine capabilities, which further augments patient evaluations and consultation. The NETT Network will perform research studies that will ultimately result in new and effective treatment s of neurological emergencies. These new treatments will be disseminated to practicing doctors and their patients and will improve the health and lives of the public.

描述（由申请人提供）：相对于其对社会的影响，急性神经系统疾病的研究非常少。许多神经系统问题需要紧急评估和治疗，最好由多学科团队进行。 NETT 网络的建立就是为了解决这些问题，因为发现和实施神经紧急情况的有效治疗方法将需要从大规模临床试验中得出的复杂研究方案。这一举措的成功不仅取决于协调良好的中央数据管理中心，还取决于有能力在大量人口中紧急登记患者的中心和辐射站点。该计划的广泛和长期目标是测试和制定针对神经系统紧急情况的新有效疗法，并改善美国人的整体健康状况。该项目设计是一个中央协调“中心”（韦恩州立大学急诊医学系 - WSU），该中心在急诊患者护理和基于急诊的临床试验方面拥有经过验证的专业知识。 “Spokes”（底特律医疗中心和 William Beaumont 医院）提供：i) 从实验室到临床的神经科学专业知识，2) 经证实的将患者纳入紧急介入试验的能力，3) 超过 500,000 次急诊科就诊次数覆盖密歇根州东南部的人口统计数据以及 4) 医院间、部门间和跨学科合作的悠久历史。罗伯特·韦尔奇博士与布莱恩·奥尼尔博士合作，拥有一批令人羡慕的既定合作者，其中包括成人和儿科急诊医学医师、神经科医生、神经外科医生、重症监护专家和创伤外科医生。华盛顿州立大学“中心”在院前启动并持续到急诊室、住院和康复阶段的紧急干预试验方面拥有丰富的经验。 WSU 研究人员已成功将患者纳入院前介入试验 Res-Q、PAD、PolyHeme、DCAR、POST 和脑血氧饱和度试验。此外，这些研究人员还领导了各种紧急介入试验的入组患者，例如 RESCUE、TIA-ADP、PECARN、ONO-REACT、BADHIT、Gen-IMS、PROACTION 和 RESCUE-ACS。在每项试验中，我们的站点都超出了预期，并为主要研究人员提供了大量、高质量的干净数据。其中许多研究需要社区协商才能实施。 WSU 站点配备了连接各医院站点的集成且先进的电子病历系统。该系统具有先进的远程医疗功能，进一步增强了患者评估和咨询。 NETT 网络将进行研究，最终为神经系统紧急情况提供新的有效治疗方法。这些新疗法将传播给执业医生及其患者，并将改善公众的健康和生活。