SUPPLEMENT- Using design thinking approaches to tailor a dyadic behavioral sleep intervention for persons living with dementia and their caregivers

补充-使用设计思维方法为痴呆症患者及其护理人员量身定制二元行为睡眠干预措施

• 批准号: 10535237
• 负责人: Glenna Shemida Brewster
• 金额: $ 5.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10535237
• 关键词: Affect; Alzheimer' s disease related dementia; Behavior Therapy; Behavioral; Caregiver research; Caregivers; Clinical Trials; Cognitive Therapy; Dementia; Dementia caregivers; Development; Diagnosis; Disease; Foundations; Future; Goals; Health; Health Personnel; Human; Individual; Intervention; Intervention Trial; Interview; K-Series Research Career Programs; Knowledge; Manuscripts; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; National Institute on Aging; Oral; Outcome; Peer Review; Persons; Phase; Population; Prevalence; Process; Public Health; Quality of life; Randomized Controlled Trials; Research; Research Project Grants; Sleep; Sleep disturbances; Sleeplessness; Structure; Testing; Thinking; Training; Waiting Lists; Writing; analytical method; behavioral/social science; caregiving; dementia caregiving; depressive symptoms; design; improved; innovation; member; mild cognitive impairment; novel; patient oriented; programs; skills; social neuroscience; theories

PROJECT SUMMARY Sleep disturbance is prevalent in persons living with mild cognitive impairment or early-stage Alzheimer’s disease and related dementias (PLwCI) as well as their caregivers. This prevalence suggests that sleep disturbance is an interdependent process that synergistically affects both members of the caregiving dyad. Sleep disturbance is associated with poorer health outcomes, including higher depressive symptoms and lower quality of life. Cognitive behavioral therapy for insomnia (CBTi) is effective for improving sleep disturbance in many populations, and support from a partner during CBTi results in more successful outcomes. The interdependence of PLwCI-caregiver sleep disturbance suggests the need for a dyadic intervention. However, there are no structured fully dyadic interventions focused on managing sleep disturbance in PLwCI and their caregivers; moreover, no dyadic interventions have been developed with input from these stakeholders. Aligned with the National Institute of Aging’s Behavioral and Social Science and Neuroscience high-priority dementia caregiver research agenda, the proposed K23 Patient-Oriented Mentored Career Development Award seeks to use design thinking, human-centered approaches within the CBTi framework to tailor a dyadic intervention for PLwCI and their caregivers. Twenty PLwCI-caregiver dyads and 10 healthcare providers will be interviewed during the tailoring phase. We will then conduct a waitlist randomized control trial (N = 40 dyads) to test the acceptability, feasibility, and preliminary immediate and sustained efficacy (3 months) of the dyadic intervention. The completion of this mentored research project will enable me to acquire foundational knowledge for conducting large-scale intervention trials and fulfill the need for effective dyadic interventions to treat sleep disturbance in PLwCI and caregiver dyads. The interdisciplinary training plan and goals developed for this K23 award will fill a critical gap in my current skill set. Building on my training as a clinician with expertise in sleep and dementia caregiving, I will develop proficiency in 1) design thinking approaches, 2) dyadic theories, concepts, and analytic methods, 3) identification and diagnosis of dementia-related disorders, including a focus on how these disorders relate to sleep disturbance, and 4) scientific writing, oral presentations, manuscript development, and peer review. I have assembled an excellent team of mentors (Drs. Hepburn, Barton, Lyons and Lah) and a collaborator (Dr. Gehrman). The K23 award will provide me with the necessary foundation to build a successful and independent program of research related to sleep, dementia, and caregiving.

项目概要 睡眠障碍在患有轻度认知障碍或早期阿尔茨海默氏病的人群中普遍存在 和相关痴呆症（PLwCI）及其照顾者的这种患病率表明睡眠障碍是睡眠障碍。 一个相互依赖的过程，协同影响护理二人组的两个成员 睡眠障碍。 与较差的健康结果相关，包括较高的抑郁症状和较低的生活质量。 失眠认知行为疗法 (CBTi) 可有效改善许多人的睡眠障碍 CBTi 期间合作伙伴的支持会带来更成功的结果。 PLw​​CI 护理人员的睡眠障碍表明需要进行二元干预，但目前尚无此类干预措施。 结构化的完全二元干预措施，重点关注 PLwCI 及其护理人员的睡眠障碍管理； 此外，尚未根据这些利益相关者的意见制定任何双元干预措施。 国家老龄化研究所行为、社会科学和神经科学高度优先的痴呆症护理人员 研究议程中，拟议的 K23 以患者为导向的指导职业发展奖旨在利用设计 CBTi 框架内的思维、以人为本的方法，为 PLwCI 和 他们的护理人员将在调查期间接受采访。 然后，我们将进行等候名单随机对照试验（N = 40 对）来测试可接受性， 二元干预的可行性以及初步的即时和持续疗效（3个月）。 完成这个指导性研究项目将使我能够获得进行研究的基础知识 大规模干预试验并满足有效二元干预治疗睡眠障碍的需求 PLw​​CI 和护理人员二人组为此 K23 奖项制定的跨学科培训计划和目标将填补 基于我作为一名具有睡眠和痴呆症专业知识的临床医生的培训，我目前的技能存在重大差距。 护理方面，我将熟练掌握 1) 设计思维方法，2) 二元理论、概念和分析 方法，3）识别和诊断痴呆相关疾病，包括关注这些疾病如何 与睡眠障碍有关，以及 4) 科学写作、口头演示、手稿开发和同行 我组建了一支优秀的导师团队（赫本博士、巴顿博士、莱昂斯博士和拉赫博士）和一位合作者。 （格尔曼博士）。K23 奖将为我提供必要的基础，以建立一个成功的、 与睡眠、痴呆症和护理相关的独立研究项目。