Effects of maternal opioid use disorder on neural and behavioral indicators of caregiving

母亲阿片类药物使用障碍对护理神经和行为指标的影响

• 批准号: 10534485
• 负责人: Francesca Penner
• 金额: $ 6.51万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534485
• 关键词: Adult; Affect; Age-Months; Attention; Behavior; Behavioral; Brain; Cells; Child; Child Development; Child Rearing; Clinical; Control Groups; Cues; Data; Development; Drug Addiction; Drug usage; Electroencephalography; Enrollment; Epidemic; Event-Related Potentials; Face; Face Processing; Faculty; Family; Future; Generations; Genes; Goals; Health; Individual; Infant; Interpersonal Relations; Intervention; Investigation; Knowledge; Life; Link; Longevity; Measurement; Measures; Mental disorders; Methodology; Mothers; National Institute of Drug Abuse; Nature; Neurobiology; Nicotine Dependence; Opiate Addiction; Opioid; Outcome; Parents; Patient Self-Report; Pattern; Population; Population Intervention; Postpartum Period; Pregnancy; Prevention; Public Health; Recovery; Reporting; Research; Research Methodology; Rewards; Risk; Sampling; Scientist; Societies; Stimulus; Substance Use Disorder; Techniques; Testing; Training; United States; Vertebral column; Woman; Work; addiction; adverse outcome; base; career; caregiving; caregiving outcomes; comparison group; cost; disorder control; improved; infancy; intergenerational; maternal caregiving; maternal opioid use; medication-assisted treatment; neural circuit; neural patterning; neuromechanism; non-opioid analgesic; novel; offspring; opioid epidemic; opioid misuse; opioid use; opioid use disorder; peer; polysubstance use; prevent; relating to nervous system; research study; response; skills; substance use; temporal measurement; transmission process

Project Summary Opioid use disorder (OUD) is a major public health problem with a high cost burden and multi- generational adverse consequences. In particular, rates of OUD during pregnancy and postpartum have quadrupled in the last two decades and pose a critical threat to maternal caregiving during the sensitive period of infancy. While extant research points to the negative effects of maternal addiction on parenting behavior and child outcomes—including increased risk of later substance use problems in offspring—little is known about the caregiving effects of maternal addiction to opioids in particular. This gap in research extends to our understanding of neural mechanisms that underlie caregiving behavior, which have yet to be examined in mothers with OUD. In line with NIDA’s Strategic Objectives 1.3 and 4.1, the overall goal of the proposed multi-method research study is to provide novel data on the specific early caregiving consequences of maternal OUD across neural, behavioral, and self-report levels of analysis. As an add-on to an existing study of maternal opioid use trajectories following pregnancy, this study will evaluate neural and behavioral caregiving indicators at 5-months postpartum, and infant socio-emotional development at 6-months postpartum, in mothers receiving medication assisted treatment (MAT) for OUD and demographically-matched control mothers without OUD. Aim 1 will utilize event- related potentials (ERP) to examine differences in neural response to infant cues in mothers with OUD compared to controls. Aim 2 will examine differences in self-reported and observed caregiving in mothers with and without OUD and will test associations between mothers’ neural responses to infant cues and self-reported and observed caregiving behavior. Aim 3 will examine links between mothers’ neural responses to infant cues and infant socio- emotional development, and between maternal caregiving and infant socio-emotional development, in both groups. The exploratory aim will use latent profile analysis to identify patterns of neural responses in mothers and test whether these patterns are associated with maternal OUD status and caregiving. Overall, this research will identify neural and behavioral caregiving correlates of maternal OUD during the critical postpartum period that will advance current knowledge on the consequences of maternal OUD and inform future interventions with mothers with opioid use problems. Findings can therefore support efforts to improve caregiving and prevent negative child outcomes, including the intergenerational transmission of substance use disorders, in families with maternal opioid addiction. In line with these study aims, the proposed training plan, supported by the sponsor and five additional faculty experts, includes goals to build substantive knowledge in parental addiction and parent-infant relationships as well as methodological skills in EEG/ERP measurement and observational assessment. This proposal will strengthen the applicant’s background and help launch her research career as a clinical scientist focused on parental addiction and prevention of the intergenerational transmission of addiction.

项目摘要 阿片类药物使用障碍（OUD）是一个主要的公共卫生问题 世代不利后果。特别是，怀孕期间和产后的OUD发生率 在过去的二十年中进行了三倍 婴儿期。而广泛的研究表明，母育成瘾对育儿行为的负面影响和 儿童结局 - 包括后代后期使用物质使用问题的风险增加，对此有所了解 孕产妇成瘾对阿片类药物的影响。研究差距扩展到我们的理解 源于护理行为的神经机制，这些神经机制尚未在OUD母亲中进行检查。 符合NIDA的战略目标1.3和4.1，这是拟议的多方法研究的总体目标 研究是为了提供有关母亲在神经跨神经的特定早期护理后果的新数据 行为和自我报告的分析水平。作为现有的母体阿片类药物使用轨迹研究的附件 怀孕后，本研究将在产后5个月的时间里评估中性和行为照顾指标， 和婴儿产后6个月的婴儿社会情感发展，接受药物辅助的母亲 没有OUD的OUD和人口统计学匹配的对照母亲的治疗（MAT）。 AIM 1将利用事件 - 相关电位（ERP）检查了OUD母亲的神经反应对婴儿提示的差异 进行控件。 AIM 2将检查有或没有的母亲的自我报告和观察到的照顾的差异 OUD并将测试母亲对婴儿提示的神经反应与自我报告和观察的关联 护理行为。 AIM 3将研究母亲对婴儿提示的神经反应与婴儿社会的联系 情绪发展，以及在两者之间的母校照顾和婴儿社会情感发展之间 组。探索性目的将使用潜在概况分析来识别母亲的神经反应模式 并测试这些模式是否与孕产妇的状态和照料有关。总体而言，这项研究 将在关键产后确定母体ouD的神经和行为照顾相关性 这将促进有关母亲oud后果的当前知识，并通过 患有阿片类药物使用问题的母亲。因此，调查结果可以支持改善照料和预防的努力 负面的儿童结果，包括物质使用障碍的代际传播， 产妇阿片类药物成瘾。符合这些研究的目的，拟议的培训计划，由赞助商支持 另外五位教师专家包括建立父母成瘾和的实质性知识的目标 脑电图/ERP测量和观察性的亲戚关系以及方法论技巧 评估。该建议将加强申请人的背景，并帮助她作为一个研究职业 临床科学家着重于父母成瘾和预防成瘾的代际传播。