Effects of maternal opioid use disorder on neural and behavioral indicators of caregiving

母亲阿片类药物使用障碍对护理神经和行为指标的影响

基本信息

批准号：
10534485
负责人：
Francesca Penner
金额：
$ 6.51万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10534485
关键词：
Adult Affect Age-Months Attention Behavior Behavioral Brain Cells Child Child Development Child Rearing Clinical Control Groups Cues Data Development Drug Addiction Drug usage Electroencephalography Enrollment Epidemic Event-Related Potentials Face Face Processing Faculty Family Future Generations Genes Goals Health Individual Infant Interpersonal Relations Intervention Investigation Knowledge Life Link Longevity Measurement Measures Mental disorders Methodology Mothers National Institute of Drug Abuse Nature Neurobiology Nicotine Dependence Opiate Addiction Opioid Outcome Parents Patient Self-Report Pattern Population Population Intervention Postpartum Period Pregnancy Prevention Public Health Recovery Reporting Research Research Methodology Rewards Risk Sampling Scientist Societies Stimulus Substance Use Disorder Techniques Testing Training United States Vertebral column Woman Work addiction adverse outcome base career caregiving caregiving outcomes comparison group cost disorder control improved infancy intergenerational maternal caregiving maternal opioid use medication-assisted treatment neural circuit neural patterning neuromechanism non-opioid analgesic novel offspring opioid epidemic opioid misuse opioid use opioid use disorder peer polysubstance use prevent relating to nervous system research study response skills substance use temporal measurement transmission process

项目摘要

Project Summary Opioid use disorder (OUD) is a major public health problem with a high cost burden and multi- generational adverse consequences. In particular, rates of OUD during pregnancy and postpartum have quadrupled in the last two decades and pose a critical threat to maternal caregiving during the sensitive period of infancy. While extant research points to the negative effects of maternal addiction on parenting behavior and child outcomes—including increased risk of later substance use problems in offspring—little is known about the caregiving effects of maternal addiction to opioids in particular. This gap in research extends to our understanding of neural mechanisms that underlie caregiving behavior, which have yet to be examined in mothers with OUD. In line with NIDA’s Strategic Objectives 1.3 and 4.1, the overall goal of the proposed multi-method research study is to provide novel data on the specific early caregiving consequences of maternal OUD across neural, behavioral, and self-report levels of analysis. As an add-on to an existing study of maternal opioid use trajectories following pregnancy, this study will evaluate neural and behavioral caregiving indicators at 5-months postpartum, and infant socio-emotional development at 6-months postpartum, in mothers receiving medication assisted treatment (MAT) for OUD and demographically-matched control mothers without OUD. Aim 1 will utilize event- related potentials (ERP) to examine differences in neural response to infant cues in mothers with OUD compared to controls. Aim 2 will examine differences in self-reported and observed caregiving in mothers with and without OUD and will test associations between mothers’ neural responses to infant cues and self-reported and observed caregiving behavior. Aim 3 will examine links between mothers’ neural responses to infant cues and infant socio- emotional development, and between maternal caregiving and infant socio-emotional development, in both groups. The exploratory aim will use latent profile analysis to identify patterns of neural responses in mothers and test whether these patterns are associated with maternal OUD status and caregiving. Overall, this research will identify neural and behavioral caregiving correlates of maternal OUD during the critical postpartum period that will advance current knowledge on the consequences of maternal OUD and inform future interventions with mothers with opioid use problems. Findings can therefore support efforts to improve caregiving and prevent negative child outcomes, including the intergenerational transmission of substance use disorders, in families with maternal opioid addiction. In line with these study aims, the proposed training plan, supported by the sponsor and five additional faculty experts, includes goals to build substantive knowledge in parental addiction and parent-infant relationships as well as methodological skills in EEG/ERP measurement and observational assessment. This proposal will strengthen the applicant’s background and help launch her research career as a clinical scientist focused on parental addiction and prevention of the intergenerational transmission of addiction.

项目概要阿片类药物使用障碍（OUD）是一个重大的公共卫生问题，具有高昂的成本负担和多方面的影响。尤其是妊娠期和产后 OUD 的发生率。过去二十年翻了两番，对敏感时期的孕产妇护理构成严重威胁虽然现有的研究指出母亲成瘾对养育行为和行为的负面影响。儿童结局——包括后代出现药物滥用问题的风险增加——人们对这一问题知之甚少。尤其是母亲对阿片类药物成瘾的护理影响，这一研究差距延伸到了我们的理解。照顾行为背后的神经机制尚未在患有 OUD 的母亲中进行检查。根据 NIDA 的战略目标 1.3 和 4.1，拟议的多方法研究的总体目标研究的目的是提供关于产妇 OUD 对神经、作为现有母亲阿片类药物使用轨迹研究的补充。怀孕后，这项研究将评估产后 5 个月的神经和行为护理指标，接受药物辅助的母亲在产后 6 个月时的婴儿社会情感发展 OUD 和没有 OUD 的人口统计匹配对照母亲的治疗 (MAT) 目标 1 将利用事件-。相关电位（ERP）来检查 OUD 母亲对婴儿线索的神经反应差异目标 2 将检查有或没有护理的母亲自我报告和观察到的护理差异。 OUD 并将测试母亲对婴儿线索的神经反应与自我报告和观察之间的关联目标 3 将检查母亲对婴儿线索的神经反应与婴儿的社会行为之间的联系。情感发展，以及母亲的照顾和婴儿的社会情感发展之间，探索性目标将使用潜在特征分析来识别母亲的神经反应模式。并测试这些模式是否与母亲 OUD 状态和护理有关。将确定产后关键时期母亲 OUD 的神经和行为护理相关性这将增进目前对孕产妇 OUD 后果的认识，并为未来的干预措施提供信息因此，研究结果可以支持改善护理和预防阿片类药物使用问题的母亲。在患有此类疾病的家庭中，儿童的负面结果，包括物质使用障碍的代际传播根据这些研究目标，拟议的培训计划得到了申办者的支持。和另外五名专家教师，包括建立有关父母成瘾的实质性知识的目标和亲子关系以及 EEG/ERP 测量和观察的方法技能该评估将加强申请人的背景并帮助她开展研究生涯。临床科学家专注于父母成瘾和预防成瘾代际传播。