Elucidating the role of jails in MRSA community transmission

阐明监狱在 MRSA 社区传播中的作用

• 批准号: 10534058
• 负责人: Timileyin Adediran
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534058
• 关键词: Address; Amplifiers; Back; Black Populations; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Chicago; Clinical; Code; Color; Communities; County; Data; Epidemic; Epidemiologic Methods; Epidemiologist; Epidemiology; Event; Fibrinogen; Genome; Genomics; Health system; Healthcare; High Prevalence; Imprisonment; Individual; Infection; Intervention; Jail; Knowledge; Lead; Length of Stay; Longitudinal cohort; Metadata; Modeling; Morbidity - disease rate; Pattern; Play; Population; Prevalence; Prisoner; Prisons; Research; Resources; Risk; Role; Shelter facility; Social Network; Staphylococcus aureus infection; Testing; Training; base; burden of illness; community intervention; community transmission; community-level factor; cooking; design; feeding; genome sequencing; healthcare community; high risk; high risk population; improved; insight; low socioeconomic status; mathematical model; methicillin resistant Staphylococcus aureus; mortality; pathogen; people of color; prevent; rearrest; recidivism; skills; transmission process; underserved community; whole genome

Project Summary Methicillin-resistant Staphylococcus aureus is a serious threat according to the Centers for Disease Control and Prevention (CDC), due to the increased morbidity and mortality among individuals who are infected with this pathogen.1 As a common healthcare- and community-associated pathogen, MRSA has a high burden of disease with over 300,000 cases and roughly 11,000 deaths in 2017.1 Though the overall rates of MRSA infection have been decreasing nationwide, this has not translated in communities of color, as the rates of healthcare-associated (HA), healthcare-associated community onset (HACO), and community-acquired (CA) MRSA is much higher among blacks compared to white individuals. 2–6In addition, we understand that jails have a disproportionately high prevalence rate of MRSA (19%) and a high proportion of people of color.7,8 Detainees have high rates of recidivism with about 76.6% of prisoners are rearrested within five years. 8 Once released, detainees interact with the community they came from prior entering the jail, resulting in potential transmission events. What is not well-understood is if jails themselves are an amplifier of MRSA community transmission. In this proposal, we will investigate the relationship between jail transmission of MRSA and the potential of transmission spillover into the wider community by utilizing genomic-based regression approaches and individual-based modelling. The results will elucidate how can jails amplify community transmission, especially among communities of color, and may perpetuate high rates of MRSA infections and/or colonization. Understanding this phenomenon will allow us to improve MRSA surveillance in these communities and design and increase targeted interventions in communities of color and within jails that potentially feed into their communities.

项目摘要 根据疾病中心，耐甲氧西林金黄色葡萄球菌是严重的威胁 由于感染的个体的发病率和死亡率增加，控制与预防（CDC） 1作为一种常见的医疗保健和社区相关病原体，MRSA负担很高 2017.1的疾病，大约有300,000例，大约11,000例死亡。 在全国范围内，感染一直在减少，这尚未在有色社区中翻译成 医疗保健相关（HA），医疗保健相关的社区发作（HACO）和社区获得（CA） 与白人相比，黑人的MRSA要高得多。 2–6英寸补充，我们知道监狱有 MRSA（19％）和有色人种比例高的人的患病率不成比例。7,8拘留所 具有较高的累犯率，约有76.6％的囚犯在五年内被撤退。 8释放， 拘留者与他们在入狱之前来自的社区互动，导致潜在的传播 事件。没有充分理解的是，如果监狱自己是MRSA社区传播的放大器。 在此提案中，我们将调查MRSA监狱传播与潜力之间的关系 通过使用基于基因组的回归方法和 基于个体的建模。结果将阐明监狱如何扩大社区传播，尤其是 在有色社区中，可能会使MRSA感染和/或定植的高率永久存在。 了解这种现象将使我们能够改善这些社区和设计的MRSA监视 并增加了有色人种和监狱内的目标干预措施，这些干预措施可能会进食 社区。