Elucidating the role of jails in MRSA community transmission

阐明监狱在 MRSA 社区传播中的作用

• 批准号: 10534058
• 负责人: Timileyin Adediran
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534058
• 关键词: Address; Amplifiers; Back; Black Populations; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Chicago; Clinical; Code; Color; Communities; County; Data; Epidemic; Epidemiologic Methods; Epidemiologist; Epidemiology; Event; Fibrinogen; Genome; Genomics; Health system; Healthcare; High Prevalence; Imprisonment; Individual; Infection; Intervention; Jail; Knowledge; Lead; Length of Stay; Longitudinal cohort; Metadata; Modeling; Morbidity - disease rate; Pattern; Play; Population; Prevalence; Prisoner; Prisons; Research; Resources; Risk; Role; Shelter facility; Social Network; Staphylococcus aureus infection; Testing; Training; base; burden of illness; community intervention; community transmission; community-level factor; cooking; design; feeding; genome sequencing; healthcare community; high risk; high risk population; improved; insight; low socioeconomic status; mathematical model; methicillin resistant Staphylococcus aureus; mortality; pathogen; people of color; prevent; rearrest; recidivism; skills; transmission process; underserved community; whole genome

Project Summary Methicillin-resistant Staphylococcus aureus is a serious threat according to the Centers for Disease Control and Prevention (CDC), due to the increased morbidity and mortality among individuals who are infected with this pathogen.1 As a common healthcare- and community-associated pathogen, MRSA has a high burden of disease with over 300,000 cases and roughly 11,000 deaths in 2017.1 Though the overall rates of MRSA infection have been decreasing nationwide, this has not translated in communities of color, as the rates of healthcare-associated (HA), healthcare-associated community onset (HACO), and community-acquired (CA) MRSA is much higher among blacks compared to white individuals. 2–6In addition, we understand that jails have a disproportionately high prevalence rate of MRSA (19%) and a high proportion of people of color.7,8 Detainees have high rates of recidivism with about 76.6% of prisoners are rearrested within five years. 8 Once released, detainees interact with the community they came from prior entering the jail, resulting in potential transmission events. What is not well-understood is if jails themselves are an amplifier of MRSA community transmission. In this proposal, we will investigate the relationship between jail transmission of MRSA and the potential of transmission spillover into the wider community by utilizing genomic-based regression approaches and individual-based modelling. The results will elucidate how can jails amplify community transmission, especially among communities of color, and may perpetuate high rates of MRSA infections and/or colonization. Understanding this phenomenon will allow us to improve MRSA surveillance in these communities and design and increase targeted interventions in communities of color and within jails that potentially feed into their communities.

项目概要 据疾病中心称，耐甲氧西林金黄色葡萄球菌是一个严重威胁 控制和预防 (CDC)，由于感染者的发病率和死亡率增加 1 作为一种常见的医疗保健和社区相关病原体，MRSA 具有很高的负担 2017 年，该疾病的病例数超过 300,000 例，死亡人数约为 11,000 人。1 尽管 MRSA 的总体发病率 全国范围内的感染率一直在下降，但这并没有转化为有色人种社区，因为 医疗保健相关 (HA)、医疗保健相关社区发病 (HACO) 和社区获得性 (CA) 与白人相比，黑人中的耐甲氧西林金黄色葡萄球菌 (MRSA) 含量要高得多 2-6 此外，我们知道监狱里也有这样的情况。 耐甲氧西林金黄色葡萄球菌 (MRSA) 的患病率过高 (19%)，且有色人种比例很高。7,8 被拘留者 累犯率很高，约 76.6% 的囚犯在五年内再次被捕 8 一旦释放， 被拘留者与进入监狱之前所在的社区互动，导致潜在的传播 尚不清楚的是，监狱本身是否是 MRSA 社区传播的放大器。 在本提案中，我们将调查 MRSA 的监狱传播与潜在的感染之间的关系。 通过利用基于基因组的回归方法来控制传播溢出到更广泛的社区 基于个人的建模结果将阐明监狱如何放大社区传播。 有色人种社区中存在这种现象，并可能使 MRSA 感染和/或定植率保持较高水平。 了解这一现象将使我们能够改善这些社区的 MRSA 监测并设计 并增加对有色人种社区和监狱内的有针对性的干预措施，这可能会影响他们的生活 社区。