MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE

指导以患者为导向的研究，以优化慢性肾脏病的心血管结果

• 批准号: 10525521
• 负责人: Sankar Dass Navaneethan
• 金额: $ 11.82万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525521
• 关键词: Adoption; Affect; Agonist; Albumins; Albuminuria; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Area; Biological Markers; Cardiac; Cardiovascular Diseases; Cardiovascular system; Chronic Kidney Failure; Clinical; Clinical Practice Guideline; Clinical Research; Clinical Trials; Creatinine; Data; Diabetes Mellitus; Diagnostic; Disease Progression; Documentation; EFRAC; Educational workshop; End stage renal failure; Enrollment; Event; Faculty; Functional disorder; Future; GLP-I receptor; Glucose; Goals; Guidelines; Health system; Heart Atrium; Heart failure; High Prevalence; Hospitalization; Hypertension; Hypoglycemic Agents; Inflammation; Institution; International; Intervention Studies; Kidney; Kidney Diseases; Kidney Failure; Leadership; Learning; Left; Lung; Medical Students; Medicine; Mentors; Metabolic Diseases; Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Oxidative Stress; Patients; Pattern; Pharmaceutical Preparations; Placebos; Population; Pulmonary Hypertension; Renal dialysis; Renal function; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Sodium; Testing; Therapeutic; Therapeutic Agents; Time; Toxin; Tubular formation; Vascular calcification; Ventricular; Veterans Health Administration; advanced disease; aged; burden of illness; cardiovascular risk factor; clinical practice; college; diabetic; endothelial dysfunction; epidemiology study; experience; follow-up; improved; improved outcome; inhibitor; interest; lung pressure; mortality; mortality risk; non-diabetic; novel therapeutics; patient oriented research; pressure; professor; pulmonary arterial pressure; research study; skills; symporter; systematic review; uptake; urinary

PROJECT SUMMARY This application is for a K24 Midcareer Investigator Award in Patient-Oriented Research for Dr. Sankar Navaneethan. He is a Professor of Medicine and Director of Clinical Research in the Section of Nephrology, at Baylor College of Medicine. Dr. Navaneethan’s research projects have focused on improving cardiovascular and kidney outcomes for those with and at risk of chronic kidney disease (CKD). He has extensive experience in epidemiological investigations, clinical trials, and systematic reviews. Over the past decade, he has mentored trainees at different levels including medical students, residents, fellows, and junior faculty on various patient-oriented research studies. Current proposal would help him achieve following goals: a) dedicate additional time to mentor young investigators in various patient-oriented research projects related to cardiovascular disease in kidney disease, b) learn new skills in mentoring skills through both formal courses and workshops and interactions from mentors within and outside his institution, c) enhance ongoing patient- oriented research activities in obesity and impact of other metabolic diseases on cardiovascular disease in CKD population, d) to identify new scientific areas of patient-oriented research that are critical to improvement in cardiovascular outcomes of CKD population, and e) to develop leadership skills. Proposed research projects by the applicant over the 5-years would help understand the uptake of and barriers in the adoption of cardio- kidney protective medications among those with kidney disease and investigate the potential role of sodium- glucose cotransporter-2 inhibitors (SGLT2i) in improving outcomes of those with pulmonary hypertension. These projects would utilize and expand PI’s current research infrastructure and provide data for future interventional studies. Aim of the first project is to study the pattern of initiation and uptake of SGLT2i and glucagon-like peptide-1 receptor agonists (GLP-1RA) among those with kidney disease using data collected from the Veterans Affairs health system. Objectives of the second project is to conduct a pilot non-randomized study to examine the effects of SGLT2i on pulmonary artery pressure in those with CKD.

项目摘要 该申请是为Sankar博士的K24中级护理研究员奖。 纳瓦尼山。他是医学教授兼肾脏病科临床研究主任，AT 贝勒医学院。纳瓦尼丹博士的研究项目致力于改善心血管 以及患有慢性肾脏疾病（CKD）风险的人的肾脏结局。他有丰富的经验 在流行病学研究，临床试验和系统评价中。在过去的十年中，他有 在不同级别的梅里德学员，包括医学生，居民，研究员和初级教师 各种面向患者的研究。当前的建议将帮助他实现以下目标：a）专门 在各种面向患者的研究项目中，额外的时间与与患者有关 肾脏疾病中的心血管疾病，b）通过两种正式课程学习心理技能的新技能 以及他机构内外的导师的讲习班和互动，c）增强正在进行的患者 - 肥胖和其他代谢疾病对心血管疾病的影响的研究活动 CKD人群，d）确定面向患者的研究的新科学领域，这对于改进至关重要 在CKD人群的心血管成果中，以及E）发展领导能力。拟议的研究项目 申请人在五年内将有助于了解采用心脏的吸收和障碍 肾脏疾病患者受到保护的药物，并研究了钠的潜在作用 葡萄糖共转运蛋白-2抑制剂（SGLT2I）改善患有肺动脉高压患者的预后。 这些项目将利用和扩展PI当前的研究基础架构，并为将来提供数据 介入研究。第一个项目的目的是研究sglt2i的主动性和吸收模式 胰高血糖素样肽-1受体激动剂（GLP-1RA）使用收集的数据 来自退伍军人事务卫生系统。第二个项目的目标是进行非随机的飞行员 研究检查SGLT2I对CKD患者中肺动脉压力的影响。