Engagement and outreach to achieve a FAIR data ecosystem for the BICAN

参与和推广，为 BICAN 实现公平的数据生态系统

• 批准号: 10523908
• 负责人: HUA XU
• 金额: $ 97.37万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523908
• 关键词: Address; Agreement; Area; Atlases; Automobile Driving; BRAIN initiative; Big Data; Biometry; Brain; Cataloging; Cells; Collaborations; Communication; Communities; Data; Data Analytics; Data Coordinating Center; Data Discovery; Data Science; Data Scientist; Data Set; Development; Discipline; Disease; Elements; Engineering; Ensure; Equipment and supply inventories; FAIR principles; Feedback; Goals; Health; Human; Image; Individual; Informatics; Ion Channel; Knowledge; Logistics; Machine Learning; Metadata; Microscopy; Modality; Monitor; Neurologic; Neurosciences; Online Systems; Ontology; Positioning Attribute; Procedures; Process; RADx Radical; Research Personnel; Resource Development; Resource Sharing; Resources; Role; Secure; Services; Slice; Speed; Structure; Subgroup; Synapses; System; Technology; Terminology; Testing; Time; United States National Institutes of Health; Validation; Woman; Work; base; brain cell; brain health; career; cell type; cloud based; computerized data processing; dashboard; data complexity; data ecosystem; data format; data modeling; data resource; data reuse; data standards; data tools; design; digital; experience; gigabyte; improved; knowledge base; member; metadata standards; multidisciplinary; multiplex assay; nanometer; nervous system disorder; neuroinformatics; outreach; petabyte; portability; programs; receptor; skills; synergism; tool; usability; user-friendly; web portal

As a part of BRAIN 2.0, the BRAIN Initiative Cell Atlas Network (BICAN) is expected to advance fundamental knowledge and enabling technology for classifying human brain cell types, understanding their organizational principles, and providing open-access digital brain cell reference atlases, emphasizing cell diversity in health and disease. Undertaking the grand challenge of BRAIN 2.0 requires the scientific community to collaborate and tap the tremendous skill and knowledge in a diverse set of disciplines outside of neuroscience. BICAN's Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) is designed to provide effective coordination benefits to the awardee network, the NIH, and the scientific community. Advancing the ambitious BICAN goals requires CUBIE to anticipate and address potential challenges in coordinating time-sensitive management activities, mitigating data complexity and tool scalability, and supporting diverse service needs. Our team is highly experienced in leading large consortia projects at national scale, such as RADx-rad Data Coordinating Center, bioCADDIE data discovery project, informatics cores for the CTSA, the national neurological data resources. We have the knowledge, skill set, and resources to launch the Engagement and Outreach element for CUBIE (CUBIE4) and work with the BICAN network in taming the structural and organizational complexity of data and driving a FAIR (Findable, Accessible, Interoperable, Reusable) data ecosystem through three facets. The Administration Facet will ensure effective communications among the awardees to maximize synergy, facilitate collaboration and resource utilization across the BRAIN Initiative. We will provide support and establish processes for network members to adhere to data models, terminology standards, data formats and structures, conforming to FAIR data principles. We will launch, maintain and enhance a Web Portal and a Data Dashboard for the BICAN network, using role-based access control and a cutting-edge content-management system. The Technology Facet will work with other CUBIE elements and BICAN network awardees to establish metadata standards for diverse brain data; apply best practices related to data interpretability and integrability; and develop a cloud-based technology testing platform to provide sandboxes for exploring, evaluating and iteratively improving tools developed through BICAN. The Service Facet will assist BICAN awardees in their development of data processing and analytics (including machine learning) tools to ensure that they are portable, scalable, and user-friendly. In particular, our biostatistics team will provide data rendering and analytics support to provide informed and timely feedback to CUBIE and the BICAN stakeholders. We contribute to diversity in multidisciplinary knowledge, women and early-career investigators, neurological diseases and brain health perspectives, and institutional inclusivity resources. Therefore, the CUBIE4 team is uniquely well-positioned to advance the overarching goals of BICAN.

作为大脑2.0的一部分，预计大脑倡议细胞地图集网络（BICAN）将推进基本知识，并使技术能够分类人类脑细胞类型，了解其组织原理，并提供开放式数字脑细胞参考图谱，从而强调健康和疾病的细胞多样性。面对大脑2.0的巨大挑战要求科学界在神经科学之外的一系列学科中进行合作并利用巨大的技能和知识。 BICAN的生物统计学，信息学和参与（CUPIE）的协调单位旨在为获奖者网络，NIH和科学界提供有效的协调益处。促进雄心勃勃的BICAN目标需要CUBIE预测和应对协调时间敏感的管理活动，缓解数据复杂性和工具可伸缩性以及支持各种服务需求的潜在挑战。我们的团队在领导国家规模的大型财团项目中经验丰富，例如RADX RAD数据协调中心，BiocAddie数据发现项目，CTSA信息核心，国家神经数据资源。我们拥有知识，技能和资源来启动Cubie（Cubie4）的参与和外展元素，并与BICAN网络合作，启动数据的结构和组织复杂性，并通过三个方面推动公平（可访问，可访问，可互操作，可重复使用的）数据生态系统。政府方面将确保获奖者之间有效的沟通，以最大程度地提高协同作用，促进整个大脑计划的协作和资源利用。我们将为网络成员提供支持并建立流程，以遵守数据模型，术语标准，数据格式和结构，并符合公平的数据原则。我们将使用基于角色的访问控制和尖端的内容管理系统来启动，维护和增强BICAN网络的Web门户网站和数据仪表板。该技术方面将与其他Cubie元素和BICAN网络获奖者合作，为各种大脑数据建立元数据标准；应用与数据可解释性和集成性相关的最佳实践；并开发一个基于云的技术测试平台，以提供用于探索，评估和迭代通过BICAN开发的工具的沙箱。该服务方面将帮助BICAN获奖者开发数据处理和分析（包括机器学习）工具，以确保其便携式，可扩展性和用户友好。特别是，我们的生物统计学团队将提供数据渲染和分析支持，以向CUBIE和BICAN利益相关者提供知情和及时的反馈。我们为多学科知识，妇女和早期研究人员，神经疾病和大脑健康的观点以及机构包容性资源做出了贡献。因此，Cubie4团队的位置良好，可以促进BICAN的总体目标。