West Virginia University Stroke COBRE

西弗吉尼亚大学中风 COBRE

• 批准号: 10523541
• 负责人: Anne Courtney DeVries
• 金额: $ 36.45万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523541
• 关键词: Acute; Address; American; Appalachian Region; Applications Grants; Basic Science; Behavior; Biological Markers; Brain; Cardiovascular Diseases; Centers of Research Excellence; Chronic; Cognitive deficits; Core Facility; Data; Development; Diabetes Mellitus; Educational workshop; Extramural Activities; Fees; Fostering; Functional disorder; Funding; Goals; Grant; Health; High Prevalence; Hypertension; Individual; Institution; Life Style; Mental Depression; Mentors; Metabolic syndrome; Mitochondria; Morbidity - disease rate; Motor; Obesity; Outcome; PF4 Gene; Patient-Focused Outcomes; Patients; Phase; Positioning Attribute; Prevalence; Prevention strategy; Research; Research Personnel; Research Project Grants; Research Training; Risk Factors; Rodent; Rural Community; Sensory; Service delivery model; Services; Smoking; Social isolation; Stroke; Tissue Banks; Training; Translational Research; Universities; West Virginia; Writing; aging population; base; behavior test; comorbidity; design; disability; faculty mentor; global health; health care availability; high risk; improved; infection risk; innovation; low socioeconomic status; modifiable risk; mortality; multidisciplinary; novel; programs; stroke model; stroke recovery; stroke rehabilitation; stroke therapy; success; sustainable resource

The Overall Objective of the WVU Stroke CoBRE is to decrease morbidity and mortality related to stroke through improved understanding of pathophysiological mechanism(s) of stroke. We will accomplish this overall goal by conducting high-quality basic and translational research addressing the modifiable risk factors, biomarkers, mechanism(s), preventative strategies, acute and chronic treatments and rehabilitation of stroke. This objective would be met by achieving the following three Specific Aims: Specific Aim 1. Expand the critical mass of funded investigators conducting stroke recovery research. In Phase II we propose to solidify the commitment of investigators to stroke research, in part, by providing cutting-edge stroke research core facilities and services (See Specific Aim 2), generating meaningful preliminary data in support of their grant applications through funding of five Junior Investigator projects, providing grantsmanship workshops/activities to improve their grant applications, and expanding the intensive mentoring program initiated in Phase I of the WVU Stroke CoBRE. Specific Aim 2. Strengthen innovative scientific cores that support and advance basic and translational stroke research. We propose to expand the scope and capacity, as well as the user-base of these vital cores. This will be accomplished by the introduction of new services (e.g., new stroke models; additional behavioral tests), and provide training sessions for research cores. In addition to the Experimental Stroke Core (ESC) and the Rodent Behavior Core (RBC), which are proposed for CoBRE funding, we will develop two additional cores, the Mitochondrial Functional Assessment Core (MFAC) and the Stroke Tissue Bank. Specific Aim 3. Advance the ongoing development of an independent, sustainable, multidisciplinary thematic program of research on stroke. The goal of achieving independences (of CoBRE funding) of the WVU Stroke CoBRE has begun and will continue in Phase II by the transition to a user-fee based funding of research core services, the independent funding of research grants that include funding for these core services and support from the WVU HSC. At the conclusion of Phase II of the WVU Stroke CoBRE, mentored training will have been provided to engage additional JIs in stroke-related research. We will have addressed the need for basic and translational research into the causes, acute and subacute treatments and recovery from stroke by (1) increasing the number of independently funded WVU stroke researchers, (2) expanding stroke research core services and user numbers, and (3) continuing the transition to sustain these resources through a user-based funding model for services at WVU.

WVU卒中索布雷的总体目标是降低发病率和死亡率 通过改善对中风的病理生理机制的理解。我们将 通过进行高质量的基础和翻译研究来实现这一总体目标 解决可修改的危险因素，生物标志物，机制，预防策略，急性 以及长期治疗和中风的康复。通过实现这一目标 以下三个具体目的：具体目标1。扩大资金研究人员的关键质量 进行中风恢复研究。在第二阶段，我们建议巩固 研究人员通过提供尖端的中风研究核心设施来部分中风研究 和服务（请参阅特定目标2），生成有意义的初步数据以支持其赠款 通过五个初级调查员项目的资金申请，提供赠款技巧 研讨会/活动以改善其赠款申请并扩大密集指导 在WVU冲程鞋底的I期中启动的程序。特定目标2。加强创新 支持并推进基本和转化中风研究的科学核心。我们建议 扩大这些重要核心的范围和容量以及用户基础。这将是 通过引入新服务（例如，新的中风模型；其他行为 测试），并为研究核心提供培训课程。除了实验中风 核心（ESC）和啮齿动物行为核心（RBC），是为鞋底资助而提出的 将开发两个额外的核心：线粒体功能评估核心（MFAC）和 中风组织库。特定目的3。促进独立的持续发展 可持续的，多学科的中风研究主题计划。实现的目标 WVU中风的独立性（索布尔资金的独立）已经开始，并将继续 第二阶段通过过渡到基于用户的研究核心服务的资金，独立 研究补助金的资金，包括为这些核心服务提供资金和WVU的支持 HSC。在WVU中风鞋底第二阶段结束时，指导的培训将进行 提供了与中风相关的研究中的其他JIS。我们将解决 需要对原因，急性和亚急性治疗以及 从中风中恢复（1）增加了独立资助的WVU中风的数量 研究人员，（2）扩大中风研究核心服务和用户数量，以及（3）继续 通过基于用户的资助模型在WVU上维持这些资源的过渡。