Translational Post-doctoral Training in Neurodevelopment

神经发育转化博士后培训

• 批准号: 10650880
• 负责人: DAVID C GLAHN
• 金额: $ 29.15万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650880
• 关键词: neurodevelopment; post-doctoral training

Project Summary/Abstract This application, “Translational Postdoctoral Training in Neurodevelopment (TPND)” is a competing renewal to request five additional years of funding in support of our Institutional Training Grant (T32). The TPND Program at Boston Children's Hospital is designed to provide promising postdoctoral investigators (MD, PhD or MD/PhD) with advanced training in essential translational topics ranging from preclinical considerations through implementation of clinical trials for individuals with a range of neurodevelopmental disorders. Large numbers of children, adolescents, and adults are affected by neurodevelopmental disorders that begin early in life, and are rooted in aberrant brain circuitry. Most currently available treatments have had limited impact on the course of neurodevelopmental disorders. Recent advances in genetics, neuroscience, and neuroimaging have led to dramatic gains in our understanding of the pathogenesis of neurodevelopmental disorders. We now have the possibility of developing mechanism-based treatments for many disorders in this field, and thus there is an urgent need for training young investigators who will become the leaders in initiating and executing research at the interface of these advances and ultimately improving the lives of individuals affected with these disorders. TPND leverages the significant strengths of the Translational Neuroscience Center (TNC), the Fuss Center for Neuropsychiatric Disease Research, and the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and Harvard Medical School to provide trainees with research experiences ranging from pre-clinical and cognitive neuroscience labs through clinical trial involvement in neurodevelopmental disorders. A key premise of this program is that effective research training in the field of translational neuroscience requires both mentors with expertise in areas across the continuum of translational research with neurodevelopmental disorders and ongoing programs to support the trainees to conduct innovative, high impact translational research. The 17 faculty mentors will involve trainees over a 2-year period (3 new entrants per year) with a range of state of the art methods in translational neurodevelopmental science that reflect core areas of the TNC program including basic science and translational methods as well as application to clinical populations in therapeutic trials for neurodevelopmental disorders. This research experience will be supplemented with both didactic and clinical immersion experiences designed to provide trainees with the skills needed to be successful independent investigators in this critical and emerging field. Ultimately this research experience will have the potential to yield new treatments and insight that in turn will impact the field by reducing the burdens and costs of care and costs to society that is now associated with neurodevelopmental disorders. In addition, the TPND will develop models of interdisciplinary research training for promising young scientists that will have a transformative impact on the field.

项目摘要/摘要 该应用程序“神经发育的翻译博士后培训（TPND）”是竞争的续约 要求额外的五年资金来支持我们的机构培训补助金（T32）。 TPND程序 在波士顿儿童医院旨在提供有前途的博士后调查人员（MD，PhD或 MD/PHD）接受了基本翻译主题的高级培训，从临床前考虑 通过为患有一系列神经发育障碍的个体实施临床试验。大的 儿童，青少年和成年人的人数受到早期开始的神经发育障碍的影响 生命，并植根于异常的脑电路。目前大多数可用的治疗对 神经发育障碍的过程。遗传学，神经科学和神经影像学的最新进展 我们对神经发育障碍的发病机理的理解导致了巨大的收益。我们现在 有可能在该领域为许多疾病开发基于机制的疗法，因此 迫切需要培训年轻调查员，他们将成为启动和执行的领导者 在这些进步的界面上进行研究，并最终改善受这些影响的个人的生活 疾病。 TPND利用了转化神经科学中心（TNC）的重要优势，大惊小怪 神经精神病研究中心和波士顿认知神经科学实验室 儿童医院和哈佛医学院为受训者提供研究经验 临床和认知神经科学实验室通过临床试验参与神经发育障碍。 该计划的关键前提是在转化神经科学领域的有效研究培训 需要在转化研究连续的领域具有专业知识的两位导师， 神经发育障碍和正在进行的计划，以支持培训以进行创新，高的培训 影响翻译研究。 17位教师导师将在2年内参与学员（3个新条目 每年）具有反映核心的转化神经发育科学中的一系列技术方法 TNC计划的领域，包括基础科学和翻译方法以及应用于临床 神经发育障碍热试验中的种群。这项研究经验将是 补充教学和临床沉浸体验，旨在为受训者提供技能 需要在这个关键和新兴领域成为成功的独立研究人员。最终这项研究 经验将有可能产生新的治疗方法，并见解，反过来又会影响该领域 减少与神经发育相关的社会的伯恩斯和成本和成本 疾病。此外，TPND将为Promise Young开发跨学科研究培训的模型 对该领域产生变革性影响的科学家。

项目成果

Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability.

• DOI: 10.1186/s13229-021-00425-x
• 发表时间: 2021-02-25
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Wilkinson CL;Nelson CA
• 通讯作者: Nelson CA

Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder.

• DOI: 10.1186/s13100-021-00256-w
• 发表时间: 2021-11-27
• 期刊: Mobile DNA
• 影响因子: 4.9
• 作者: Borges-Monroy R;Chu C;Dias C;Choi J;Lee S;Gao Y;Shin T;Park PJ;Walsh CA;Lee EA
• 通讯作者: Lee EA

Reward-Sensitive Basal Ganglia Stabilize the Maintenance of Goal-Relevant Neural Patterns in Adolescents.

• DOI: 10.1162/jocn_a_01572
• 发表时间: 2020-08
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Hubbard NA;Romeo RR;Grotzinger H;Giebler M;Imhof A;Bauer CCC;Gabrieli JDE
• 通讯作者: Gabrieli JDE

Quantitative Evaluation of Content and Age Concordance Across Developmental Milestone Checklists.

跨发展里程碑清单的内容和年龄一致性的定量评估。

• DOI: 10.1097/dbp.0000000000000695
• 发表时间: 2019
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Wilkinson,CarolL;Wilkinson,MJackson;Lucarelli,Jennifer;Fogler,JasonM;Becker,RonaldE;Huntington,Noelle
• 通讯作者: Huntington,Noelle

Prediction of autism spectrum disorder diagnosis using nonlinear measures of language-related EEG at 6 and 12 months.

• DOI: 10.1186/s11689-021-09405-x
• 发表时间: 2021-11-30
• 期刊: Journal of neurodevelopmental disorders
• 影响因子: 4.9
• 作者: Peck FC;Gabard-Durnam LJ;Wilkinson CL;Bosl W;Tager-Flusberg H;Nelson CA
• 通讯作者: Nelson CA