Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network

宾夕法尼亚州东南部成人和儿童预防中心网络

• 批准号: 10649555
• 负责人: EBBING LAUTENBACH
• 金额: $ 162.73万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649555
• 关键词: Southeastern; Pennsylvania; Adult; Pediatric; Prevention

Project Summary Healthcare-associated infections (HAIs) and antibiotic resistance (AR) are leading causes of morbidity and mortality worldwide. Concerted efforts are required to define the epidemiology and impact of emerging HAI and AR issues, as well as identify and test novel strategies to address these urgent problems. The CDC Prevention Epicenter site at the University of Pennsylvania and the Children’s Hospital of Philadelphia (i.e., the Penn- CHOP Epicenter) has been engaged in numerous initiatives focused on HAIs and AR. The considerable research support and infrastructure provided by the CDC’s Prevention Epicenters Program has served to facilitate significant scientific achievements demonstrated in part by 71 peer-reviewed publications and 110 scientific abstracts from the Penn-CHOP Epicenter group since site inception in 2011. The Penn-CHOP Epicenter has also provided a rich scientific environment within which investigators with complementary areas of expertise collaborate to address the most urgent issues in HAI and AR. Finally, the Penn-CHOP group has collaborated extensively with other CDC Epicenter sites and healthcare networks to answer critical scientific questions. The projects proposed in this application build on the strong foundation established by prior work from the Penn-CHOP investigators. These studies focus on acute, post-acute, and outpatient care settings and include adult and pediatric populations. Finally, these projects include collaborations with other sites, health care networks, public health agencies, and regional partnerships. This application is comprised of 6 Core Projects and 3 Optional Collaborative Projects: CORE PROJECTS Core Project #1: Screening and Targeted Prophylaxis for Clostridioides difficile Infection (CDI) among Immunocompromised Hosts (SToP-CDI) Core Project #2: Non-residential Exposures to Multidrug-Resistant Organisms (NEXUS) Core Project #3: Reducing Antimicrobial Prescribing in Dialysis (RAPID) Core Project #4: Microbiome Sampling in Pediatric Post-Acute Care to Understand Multidrug-resistant Organism Risk, Antibiotic Effect, and Ventilator-associated Infection (MS PAC-MAN) Core Project #5: Natural Language Processing for Antibiotic Prescribing in Sinusitis (NAPS) Core Project #6: Antibiotic Stewardship for Ambulatory Surgery Prophylaxis (ASSURE) OPTIONAL COLLABORATIVE PROJECTS Small Collaborative Project: Communication And Coaching To Increase Steward Influence (CACTIS) Medium Collaborative Project: Reducing Vancomycin Administration in Pediatric Sepsis (REVAMP-Sepsis) Large Collaborative Project: Fecal Microbiota Transplantation to Address Colonization and Environmental Contamination with Multidrug-Resistant Organisms (FACE-MDRO)

项目摘要 医疗保健相关感染（HAI）和抗生素耐药性（AR）是发病率和 全球死亡率。需要协调的努力来定义新兴海的流行病学和影响 AR问题，以及确定和测试新的策略来解决这些紧急问题。预防疾病预防疾病 宾夕法尼亚大学和费城儿童医院的中心地点（即 Chop Epicenter）已经参与了许多专注于Hais和AR的举措。大量 CDC预防震中计划提供的研究支持和基础设施已有服务 促进了71个同行评审的出版物的一部分，促进了重大的科学成就和110 自2011年网站启动以来，宾夕法尼亚州震中小组的科学摘要。Penn-Chop Epicenter还提供了丰富的科学环境 专业知识协作以解决HAI和AR中最紧迫的问题。最后，Penn-Chop小组有 与其他CDC Epicenter网站和医疗保健网络进行了广泛的合作，以回答关键的科学 问题。本申请中提出的项目建立在先前工作建立的强大基础上 来自Penn-Chop调查人员。这些研究着重于急性，急性后和门诊护理环境，以及 包括成人和小儿种群。最后，这些项目包括与其他网站的合作，健康 护理网络，公共卫生机构和区域合作伙伴关系。 该应用程序完成了6个核心项目和3个可选协作项目： 核心项目 核心项目＃1：筛查和针对性的预防梭状芽胞杆菌艰难梭菌感染（CDI） 免疫功能低下的宿主（Stop-CDI） 核心项目＃2：非住宅暴露于多种耐药生物（Nexus） 核心项目＃3：减少透析中的抗菌处方（快速） 核心项目＃4：小儿急性后的微生物组采样，以了解抗多药 生物体风险，抗生素效应和呼吸机相关感染（MS Pac-Man） 核心项目＃5：鼻窦炎抗生素处方的自然语言处理（午睡） 核心项目＃6：预防卧床外科手术的抗生素管理（Assive） 可选协作项目 小型协作项目：沟通和指导以增加管家影响力（仙人掌） 中型协作项目：减少小儿脓毒症的万古霉素给药 大型协作项目：粪便菌群移植以解决殖民和环境 用耐多药的生物（面部污染）污染