The National Center for Interventional Biophotonic Technologies (NCIBT)

国家介入生物光子技术中心 (NCIBT)

• 批准号: 10649445
• 负责人: Griffith R. Harsh
• 金额: $ 140.73万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-20 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649445
• 关键词: Acceleration; Acute; Address; Algorithms; Area; Biophotonics; Cardiology; Cerebrovascular Circulation; Clinical; Clinical Management; Cognition; Collaborations; Communities; Complement; Data; Decision Making; Degenerative Disorder; Dementia; Development; Diagnosis; Diffuse; Diffusion; Disease Management; Educational workshop; Electronic Mail; Engineering; Ensure; Equipment; Fetal health; General Population; Goals; Hand; Health; Heart Diseases; High-Risk Pregnancy; Human; Humanities; Image; Imaging Device; Imaging Techniques; Imaging technology; Immersion; Individual; Infection; Institution; Intelligence; Intervention; Legal patent; Link; Literature; Malignant Neoplasms; Medical; Medical Societies; Medical center; Medicine; Metabolism; Monitor; Near-Infrared Spectroscopy; Ophthalmology; Optics; Participant; Patient-Focused Outcomes; Patients; Perfusion; Physicians; Procedures; Program Development; Property; Public Health; Publications; Research; Research Project Grants; Resolution; Schools; Scientist; Services; Source; Spectrum Analysis; Speed; Stroke; Structure; Surgeon; Surgical Oncologist; Surgical Oncology; System; Technology; Therapeutic; Time; Tissues; Training; Training Programs; Translations; Trauma; Traumatic Shock; Vision; Visit; Visualization; Work; analytical tool; clinical application; clinical decision-making; clinical translation; commercialization; computerized tools; data streams; deep learning; design; fluorescence lifetime imaging; global health; holistic approach; image guided; imaging modality; imaging platform; improved; individualized medicine; industry partner; innovation; instrument; interest; meetings; nervous system disorder; novel; open source; optical imaging; photonics; precision medicine; program dissemination; programs; residence; social media; symposium; technology development; technology training; tumor; web site

PROJECT SUMMARY – Overall The long-term goal of the National Center for Interventional Biophotonic Technologies (NCIBT) is to promote public health by advancing a new paradigm for intraprocedural, image-guided decision making. The Center's strategy is to advance optical spectroscopy and imaging technologies, to develop means of providing imaging results to medical practitioners at the time, in the form, and within the context they will be most useful in guiding decisions, and to maximize the impact of this work by involving as many scientists and physicians as possible in developing and using these technologies. Initially, the Center will promote technological advancements of interventional fluorescence lifetime imaging (iFLIM) and interferometric diffuse optical spectroscopy (iDOS) and their translation into clinical use. An open-ended intraprocedural platform will incorporate them and, eventually, complementary optical imaging technologies. Specifically, NCIBT will (1) advance scalable optical imaging technology, built from the perspective of intelligent optical system design, to characterize tissue properties in the most effective manner; (2) develop an intraprocedural platform that physically incorporates these technologies and integrates the resulting imaging data, details of the procedure, and patient-specific information within AI- based decision algorithms that guide, in real-time, therapeutic decisions, and (3) disseminate these technological advancements to research institutions and medical centers. The significance of this project derives from its potential for rapid advancement, catalyzed by an AI-directed holistic approach to instrument design, of its optical imaging technologies and platform and their relevance to managing humanity's most common afflictions - cancer, stroke, heart disease, trauma, infection, and degenerative diseases. NCIBT will ensure the national impact of these technological advancements by creating and expanding a network of collaborative research and service projects broadly distributed nationwide and implementing a comprehensive training and dissemination program. Annual workshops, hand-on training sessions at national meetings, in special courses and at UC Davis, presentations and publications will educate, train, equip and diversify potential users of NCIBT technology. Bridging gaps between engineering and medicine and between technology development and clinical application will ensure that the needed technologies are developed and applied clinically to improve the nation's health.

项目摘要 - 总体 国家介入生物技术技术中心（NCIBT）的长期目标是促进 通过促进新的范围内术中，图像引导决策的新范式，公共卫生。中心的 策略是推进光谱和成像技术，以开发提供成像的方法 当时，以形式以及在上下文中向医生最有用的结果 决策，并通过尽可能多的科学家和医生参与其中来最大化这项工作的影响 开发和使用这些技术。最初，该中心将促进 介入的荧光寿命成像（IFLIM）和干涉弥漫性光谱（IDO）和 它们转化为临床用途。一个开放式的手术室内平台将结合起来，最终 完全光学成像技术。具体而言，NCIBT将（1）提前可扩展的光学成像 从智能光学系统设计的角度构建的技术，以表征组织特性 最有效的方式； （2）开发一个物理结合这些技术的手术室内平台 并整合所得的成像数据，程序的详细信息以及特定于患者的信息 基于决策算法，实时指导，治疗性决策，（3）传播这些技术 研究机构和医疗中心的进步。该项目的意义来自于其 快速前进的潜力，通过AI指导的仪器设计的整体方法催化其光学 成像技术和平台及其与管理人类最常见苦难的相关性 - 癌症， 中风，心脏病，创伤，感染和退化性疾病。 NCIBT将确保 通过创建和扩展协作研究和服务网络，这些技术进步 项目在全国范围内广泛分发，并实施全面的培训和传播计划。 年度研讨会，在国家会议，特殊课程和加州大学戴维斯分校举行的手工培训会议， 演讲和出版物将教育，培训，装备和多样化NCIBT技术的潜在用户。 工程和医学之间以及技术开发与临床应用之间的桥接差距 将确保在临床上开发并应用所需的技术以改善国家的健康状况。