Core D: Biospecimens and Supplementary Measures

核心 D：生物样本和补充措施

• 批准号: 10642918
• 负责人: Robyn Lorraine Woods
• 金额: $ 43.57万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642918
• 关键词: Address; Aging; Alleles; Alzheimer' s disease related dementia; Aspirin; Australia; Biological; Biological Markers; Blood; Blood Vessels; Clinical; Collaborations; Collection; Country; Data; Data Storage and Retrieval; Dementia; Dental; Diet; Disease; Elderly; Ensure; Environmental Risk Factor; Event; Future; Generations; Genomics; Health; Hearing; Hemorrhage; Image; Impaired cognition; Individual; Inflammatory; Joints; Laboratories; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Medical center; Molecular Analysis; Nerve Degeneration; Neurocognitive; Outcome; Pain; Participant; Pathology; Patient Self-Report; Pharmaceutical Preparations; Physical activity; Polypharmacy; Positron-Emission Tomography; Prevention; Questionnaires; Radiology Specialty; Resistance; Resources; Retina; Saliva; Sampling; Sleep; Sleep Apnea Syndromes; Social support; Socioeconomic Factors; Specimen; Thromboxane B2; Thromboxanes; Tissue Sample; Tissues; Trust; Tumor Tissue; Universities; Urine; Washington; adjudication; biobank; biomarker selection; cerebrovascular pathology; cognitive function; community engagement; data management; dietary; disability; falls; genomic data; healthy aging; imaging study; lifestyle factors; neuroimaging; neurovascular; optimism; psychosocial; repository; research facility; social engagement; social factors; specific biomarkers; success; tumor; Address; Aging; Alleles; Alzheimer' s disease related dementia; Aspirin; Australia; Biological; Biological Markers; Blood; Blood Vessels; Clinical; Collaborations; Collection; Country; Data; Data Storage and Retrieval; Dementia; Dental; Diet; Disease; Elderly; Ensure; Environmental Risk Factor; Event; Future; Generations; Genomics; Health; Hearing; Hemorrhage; Image; Impaired cognition; Individual; Inflammatory; Joints; Laboratories; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Medical center; Molecular Analysis; Nerve Degeneration; Neurocognitive; Outcome; Pain; Participant; Pathology; Patient Self-Report; Pharmaceutical Preparations; Physical activity; Polypharmacy; Positron-Emission Tomography; Prevention; Questionnaires; Radiology Specialty; Resistance; Resources; Retina; Saliva; Sampling; Sleep; Sleep Apnea Syndromes; Social support; Socioeconomic Factors; Specimen; Thromboxane B2; Thromboxanes; Tissue Sample; Tissues; Trust; Tumor Tissue; Universities; Urine; Washington; adjudication; biobank; biomarker selection; cerebrovascular pathology; cognitive function; community engagement; data management; dietary; disability; falls; genomic data; healthy aging; imaging study; lifestyle factors; neuroimaging; neurovascular; optimism; psychosocial; repository; research facility; social engagement; social factors; specific biomarkers; success; tumor

CORE D. BIOSPECIMENS AND SUPPLEMENTARY MEASURES SUMMARY / ABSTRACT The common theme for Core D (Biospecimens & Supplementary Measures) is to conserve and administer existing biospecimens and supplementary data collected during ASPREE, and oversee the continued generation of such data acquired through ASPREE-XT. These data relate to biological (and other) factors that influence health and disease in aging individuals, including neuroimaging for Alzheimer’s disease and related dementia (ADRD) structural pathology, and tumor specimens collected from participants who develop cancers. Core D will ensure that the specimens, images and other supplementary data will be perpetuated for future collaborations; all the while interacting closely with other Cores including Core B for clinical endpoint confirmation and Core C for Data Management. Core D consists of 2 main components which are critical to the success of the Aims proposed in the U19: (1) responsibility for biobanked biological samples including tumor tissue samples; (2) access to data from existing neuroimages to evaluate ADRD vs cerebrovascular pathology. The current and future collections of tumor tissues across both countries will be managed through Core D, which will provide the resources and expertise from the biorepositories in Australia and the U.S., linking closely with the endpoint team in Core B, responsible for providing the cancer cases for adjudication. Core D will also provide oversight of supplementary measures and provision of existing data obtained from biospecimens. Along with the Bi-National Administrative Core, Core D will contribute to the governance and decisions about biomarker access and analyses of samples. In collaboration with Core C through data storage and management, Core D will ensure that biomarker data are disseminated to the U19 for analysis related to cancer, dementia and other outcomes and include, but are not limited to, inflammatory biomarkers and genomic data (such as APOE allele data for ADRD-related studies). Core D will also manage storage and access to the collection of existing longitudinal MRI data to identify changes in neurodegenerative pathology consistent with ADRD versus vascular pathology collected in the following ASPREE substudies: ENVISion (aspirin for the prevention of cognitive decline in the Elderly: a Neuro-Vascular Imaging Study), SNORE-imaging (Study of Neurocognitive outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnea) and NEURO (effect of LDA on number of cererbral microbleeds and correlation with cognitive function).

核心D.生物测量和补充措施摘要 /摘要 核心D的共同主题（Bispecimens＆补充措施）是在ASPREE期间保存和管理现有的生物种子和补充数据，并监督通过ASPREE-TXT获得的此类数据的持续生成。这些数据与影响衰老个体健康和疾病的生物学（和其他）因素有关，包括对阿尔茨海默氏病和相关痴呆症（ADRD）结构病理学的神经影像，以及从发展癌症的参与者那里收集的肿瘤标本。核心D将确保将标本，图像和其他补充数据持续到以后的协作中；一直与其他内核紧密相互作用，包括用于临床终点确认的核心B和用于数据管理的核心C。核心D由2个主要成分组成，这对于U19中提出的目标的成功至关重要：（1）生物群体的生物样品责任，包括肿瘤组织样品； （2）访问来自现有神经图像的数据，以评估ADRD与脑血管病理学。当前和将来的两国肿瘤时间收集将通过核心D进行管理，核心D将提供来自澳大利亚和美国的生物局体的资源和专业知识，并与核心B中的端点团队紧密相关，负责为调整癌症提供调整案例。核心D还将监督补充措施，并提供从生物测量中获得的现有数据。与双国行政核心一起，核心D将有助于有关生物标志物访问和样本分析的治理和决策。通过数据存储和管理与Core C合作，Core D将确保生物标志物数据被传播到U19，以进行与癌症，痴呆症和其他结果有关的分析，并包括但不限于炎症生物标志物和基因组数据（例如与ADRD相关研究的APOE等位基因数据）。 Core D will also manage storage and access to the collection of existing longitudinal MRI data to identify changes in neurodegenerative pathology consistent with ADRD versus vascular pathology collected in the following ASPREE substudies: ENVISion (aspirin for the prevention of cognitive decline in the Elderly: a Neuro-Vascular Imaging Study), SNORE-imaging (Study of Neurocognitive outcomes, Radiological and residual Effects of Aspirin in Sleep呼吸暂停）和神经（LDA对cererbral微粒数量的影响以及与认知功能的相关性）。