CORE A: Participant Measures and Assessments
核心 A:参与者衡量和评估
基本信息
- 批准号:10642914
- 负责人:
- 金额:$ 305.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAddressAdherenceAlzheimer&aposs DiseaseAspirinAustraliaBiological MarkersBiometryBlood PressureBody WeightBody mass indexCardiovascular PhysiologyClinicalCognitiveCollectionColonoscopyComplementComplementary MedicineCountryDataData AnalysesData CollectionData ReportingData SetDementiaDoseElderlyEnsureEvaluationEventFamily Cancer HistoryFecal occult bloodFundingFutureGaitHealthHealth behaviorImpaired cognitionIncidenceKidney DiseasesLaboratoriesLife StyleLong-Term EffectsMalignant NeoplasmsMammographyMeasuresMental DepressionMethodologyModelingMolecular AnalysisMoodsNeurocognitiveNeuropsychologyOutcomePSA screeningParticipantPersonsPharmaceutical PreparationsPhysical FunctionPhysical activityPhysiologicalProceduresQuality of lifeQuestionnairesRecording of previous eventsRenal functionResearchResourcesRiskRisk FactorsScreening for cancerServicesSiteSmokingTimeTrainingVisitcancer diagnosiscognitive functioncognitive performancecomorbiditydata cleaningdata qualitydietarydisabilityexhaustionfollow-upfrailtygenetic analysisgenomic datagraspmild cognitive impairmentparticipant retentionphenotypic datapsychosocialsuccess
项目摘要
CORE A. PARTICIPANT MEASURES AND ASSESSMENTS
SUMMARY/ABSTRACT
During the course of the ASPREE study, a vast amount of clinical, physical function, cognitive and quality of life
data (~26 million data values) were collected from 19,114 participants by trained staff, resulting in excellent
participant retention (82% with full involvement at the end of the study), compliance (74% overall) and data
quality (99.6% accuracy). This Core will build on the operational success of ASPREE and provide methodological
and operational support for all participant-related study activity by coordinating, directing and managing the
physiological and neuropsychological assessments and questionnaires conducted routinely in ASPREE-XT
participants in both the U.S. and Australia. The Core services will ensure quality, accuracy and thoroughness of
data collection from participants through the implementation of comprehensive Standard Operating Procedures
(SOPs) and to ensure adherence to SOPs, staff in both countries will be trained prior to commencement of study
activity (see Admin Core). Data provided through the activities of Core A are the clinical nexus for all projects,
as Core A will provide clinical endpoint triggers to Core B for follow-up. The longitudinal phenotypic data provided
by Core A about ASPREE-XT participants will also be of vital importance for addressing the overall aims of this
U19 through completion of Project analyzes. Specifically, the collection of information related to cancer
screening, cancer incidence, progression, and outcomes are crucial for Project 1 (Cancer). Collection of
cognitive data, depression and dementia endpoints are essential for assessing dementia and mild cognitive
impairment outcomes in Project 2 (Dementia). Basic activities of daily living, physical function, exhaustion and
physical activity data will be collected for assessment of disability and frailty for Project 3 (Disability).
Consequently, the success of the U19 hinges upon the data that will be collected as part of this Core.
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核心A.参与者措施和评估
摘要/摘要
在ASPREE研究的过程中,大量的临床,身体机能,认知和生活质量
训练有素的员工从19,114名参与者中收集了数据(约2600万个数据值),从而获得了出色的数据
参与者保留(研究结束时有82%的参与),合规性(总体74%)和数据
质量(精度为99.6%)。该核心将基于Aspree的运营成功并提供方法论
以及通过协调,指导和管理所有与参与者相关的研究活动的运营支持
生理和神经心理学评估和问卷调查在Aspree-XT中进行定期进行
美国和澳大利亚的参与者。核心服务将确保质量,准确性和彻底性
通过实施综合标准操作程序从参与者那里收集数据
(SOP)并确保遵守SOP,两国的员工将在开始学习之前接受培训
活动(请参阅管理员核心)。通过核心A活动提供的数据是所有项目的临床联系,
作为核心A将为B核B提供临床终点触发器进行随访。提供的纵向表型数据
核心A关于Aspree-XT的参与者对于解决总体目标也至关重要
U19通过完成项目分析。具体而言,与癌症有关的信息收集
筛查,癌症的发病率,进展和结果对于项目1(癌症)至关重要。收集
认知数据,抑郁症和痴呆端点对于评估痴呆和轻度认知至关重要
项目2(痴呆症)中的损害结果。日常生活,身体机能,疲惫和
将收集体育活动数据,以评估项目3(残疾)的残疾和脆弱性。
因此,U19的成功取决于将作为该核心的一部分收集的数据。
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项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robyn Lorraine Woods其他文献
Robyn Lorraine Woods的其他文献
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{{ truncateString('Robyn Lorraine Woods', 18)}}的其他基金
Core D: Biospecimens and Supplementary Measures
核心 D:生物样本和补充措施
- 批准号:
10221582 - 财政年份:2019
- 资助金额:
$ 305.18万 - 项目类别:
Core D: Biospecimens and Supplementary Measures
核心 D:生物样本和补充措施
- 批准号:
10428605 - 财政年份:2019
- 资助金额:
$ 305.18万 - 项目类别:
Core D: Biospecimens and Supplementary Measures
核心 D:生物样本和补充措施
- 批准号:
10642918 - 财政年份:2019
- 资助金额:
$ 305.18万 - 项目类别:
Core D: Biospecimens and Supplementary Measures
核心 D:生物样本和补充措施
- 批准号:
10264969 - 财政年份:2019
- 资助金额:
$ 305.18万 - 项目类别:
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