Pain and Nutrition in Dementia and Alzheimers PANDA

痴呆症和阿尔茨海默病的疼痛和营养 PANDA

• 批准号: 10644355
• 负责人: Larissa J Strath
• 金额: $ 13.31万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644355
• 关键词: Acceleration; Achievement; Address; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Ancillary Study; Cell Aging; Chronic; Clinical Research; Cognition; Cognitive; Cognitive aging; Communities; Consumption; DNA Methylation; Data; Dementia; Development; Development Plans; Diagnosis; Diet; Dietary Assessment; Dietary Intervention; Disease; Early identification; Elderly; Environment; Environmental Risk Factor; Epigenetic Process; Etiology; Functional disorder; Future; Gene Expression; Genes; Goals; Grant; Health; High Prevalence; Human; Immune; Immune System Diseases; Immune system; Impaired cognition; Individual; Inflammation; Inflammatory; Institution; Intervention; K-Series Research Career Programs; Knowledge; Link; Literature; Maintenance; Measurement; Mediating; Mentors; Methylation; Modality; Modification; Morbidity - disease rate; Nervous System; Nutrient; Nutrition Assessment; Nutritional; Nutritional status; Outcome; Pain; Pain Free; Pain management; Pathologic; Pathology; Pathway interactions; Pattern; Persons; Phase; Physiological; Population; Prevalence; Prevention; Prevention strategy; Reporting; Research; Research Personnel; Risk; Serum; Statistical Data Interpretation; Symptoms; Techniques; Testing; Training; Translational Research; Vitamin A; Vitamin D; Work; age related; aging population; career development; chronic pain; chronic painful condition; clinical pain; cognitive function; comorbidity; design; dietary; effective therapy; epigenetic regulation; epigenome; epigenomics; forging; genome-wide; improved; indexing; innovation; knee pain; methylation pattern; middle age; mild cognitive impairment; multidisciplinary; novel; nutrition; nutritional genomics; nutritional supplementation; pain outcome; pre-clinical; protein expression; side effect; skills; standardize measure; translational scientist

PROJECT ABSTRACT/SUMMARY Growing evidence suggests the presence of dysregulated pain modulation in older adults, and affect which may heighten age-associated risk for chronic pain. Additionally, chronic pain and Alzheimer’s Disease and related dementias (AD/ADRD) are highly prevalent and comorbid in older adults, and research suggests that they may have overlapping etiologies and pathologies. Chronic pain may a predictor for the development of AD, and almost half of AD patients report having pain. Thus, understanding of the shared mechanisms underlying both is critical in order to develop effective treatment and prevention modalities. Recently, epigenetics has been implicated in both disease states, with many modifications of the epigenome that may go on to result in immune system dysfunction, of which is a hallmark of both chronic pain and AD. While there are many environmental factors that can influence the epigenome, nutrition status has been shown to be one of the most common and modifiable factors therein. Thus, it may be efficacious to understand dietary interactions with the epigenome to target epigenetic regulation of the development and maintenance of chronic pain and AD. Therefore, the overall goal for this mentored career development proposal (K99/R00) is to fill this knowledge gap and determine the influence of overall diet pattern as well as Vitamins A and D specifically on the epigenetic environment as it relates to chronic pain and AD/ADRD. Primary training goals for the current proposal are to: Increase knowledge and understanding of measurement techniques used to assess cognitive aging in humans, with a specific focus on mild cognitive impairment, and AD/ADRD; Further expand knowledge of nutri-epigenetics, and apply it to cognitive aging outcomes; Enhance clinical research skills related to the design, conduct and statistical analysis of multidisciplinary studies and rigorous translational research skills to function as an independent investigator. Study 1 (K99 Phase) will assess dietary differences and their associations with differences in epigenetic aging, pain, and cognition in individuals with and without chronic pain. Study 2 (R00 phase) will allow for the assessment of diet pattern as well as vitamin A and D status on DNA methylation patterns, gene and protein expression, pain and cognitive outcomes in older adults with and without mild cognitive impairment. This proposed career development plan extends from the PIs prior work in dietary and immune system modulation of pain, and will forge a path towards understanding and investigating side-effect free nutrigenomic targets that improve pain and AD/ADRD outcomes in older adults.

项目摘要/摘要 越来越多的证据表明，老年人存在失调的疼痛调节，并影响哪些 可能会增加与年龄相关的慢性疼痛风险。此外，慢性疼痛和阿尔茨海默氏病 相关痴呆症（AD/ADRD）在老年人中高度普遍，并且合并症，研究表明 他们可能具有重叠的病因和病理学。慢性疼痛可能会预测发展 AD，几乎一半的AD患者报告疼痛。这是对共享机制的理解 两者的基础对于开发有效的治疗和预防方式至关重要。最近， 表观遗传学与两种疾病状态有关，表观遗传组进行了许多修饰 导致免疫系统功能障碍，其中是慢性疼痛和AD的标志。而有 许多可能影响表观基因组的环境因素，营养状况已被证明是 其中最常见和可修改的因素。那就是了解饮食互动可能有效 鉴于表观遗传组的表观遗传学调节慢性疼痛和维持的表观遗传学调节 广告。因此，这项重要的职业发展计划（K99/R00）的总体目标是填补这一点 知识差距并确定总体饮食模式以及维生素A和D的影响 与慢性疼痛和AD/ADRD有关的表观遗传环境。当前的主要培训目标 建议是：增加对评估认知技术的测量技术的知识和理解 人类衰老，特别关注轻度认知障碍和AD/ADRD；进一步扩展 对营养学的知识，并将其应用于认知衰老的结果；提高临床研究技能 与多学科研究和严格翻译的设计，行为和统计分析有关 作为独立研究者的研究技能。研究1（K99期）将评估饮食差异 以及他们与具有和没有 慢性疼痛。研究2（R00期）将允许评估饮食模式以及维生素A和D 老年人的DNA甲基化模式，基因和蛋白质表达，疼痛和认知结果的状态 有和没有轻度认知障碍。该拟议的职业发展计划从PIS之前延伸 在饮食和免疫系统调节疼痛方面的工作，并将为理解和 调查副作用的无营养靶标，以改善老年人的疼痛和AD/ADRD结果。