Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony

动态纠缠：个体间神经同步的功能作用和机制基础

基本信息

批准号：
10644475
负责人：
Zoe Rebecca Donaldson
金额：
$ 143.17万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10644475
关键词：
Acute Animals Automobile Driving Behavior Behavioral Biological Brain Cognitive Complex Data Development Devices Dimensions Distant Dopamine Dopamine Receptor Engineering Evaluation Exhibits Gender Generations Genetic Head Human Image Implant Individual Investigation Laboratory mice Life Link Medial Mediating Mental Health Microtus Molecular Genetics Molecular Neurobiology Monitor Motion Mus Neuromodulator Neurons Optics Oxytocin Oxytocin Receptor Pair Bond Pattern Pharmacology Photometry Photons Population Positioning Attribute Prefrontal Cortex Property Resolution Rodent Role Shapes Signal Transduction Social Behavior Social Concepts Social Functioning Social Interaction System Technology Testing Thalamencephalon Therapeutic Visualization Wireless Technology Work base cell type comparative computational neuroscience genetic approach genetic manipulation hippocampal pyramidal neuron imaging approach miniaturize neglect neural neuromechanism neuroregulation novel optogenetics physical conditioning prairie vole preference sensor social social attachment social organization technology development tool two-photon wireless

项目摘要

PROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis. It remains unclear what aspects of social behavior are driven by these intriguing inter-brain dynamics. We propose to develop and apply a revolutionary set of molecular-genetic and optical tools to record and manipulate neural activity wirelessly and simultaneously in multiple interacting animals from distantly related rodent species across a broad spectrum of sociality. These studies include evaluation of synchrony parameters, along with causal imposition of synchrony to drive social behaviors and attachment. We aim to leverage novel functional genetic approaches to identify the cellular and subcellular basis and neuromodulatory mechanisms that underlie the emergence and strengthening of synchrony. This project will revolutionize our concept of the social brain, placing a multi-dimensional emphasis on neural activity within and across interacting brains, linked by the non-corporeal bonds of shared life. This is critical for understanding the full breadth of human sociality, identity, neurotypical and atypical behavior, as well as mental and physical health.

项目摘要脊椎动物的大脑已经演变为实现复杂的社会互动，这对于生存至关重要。动物的大脑从事共享的社交互动表现出神经活动的脑间同步，可在几个分析水平。尚不清楚这些有趣的脑之间的社会行为方面是什么方面动力学。我们建议开发和应用一组革命性的分子遗传和光学工具来记录并在来自遥远相关的多个相互作用的动物中无线和同时操纵神经活动啮齿动物物种遍布广泛的社会性。这些研究包括评估同步参数，以及因果施加同步以推动社会行为和依恋。我们的目标是利用小说鉴定细胞和亚细胞基础和神经调节机制的功能遗传方法这是同步的出现和增强的基础。这个项目将彻底改变我们的概念社交大脑，对互动大脑内部和跨互动的神经活动进行多维的强调，通过共享生活的非体制纽带。这对于理解人类社会的全部广度至关重要，身份，神经型和非典型行为以及心理和身体健康。