Measuring Human BAT Volume and Activity by Quantitative and Functional MRI

通过定量和功能 MRI 测量人体 BAT 体积和活动

• 批准号: 8853859
• 负责人: Jie Deng
• 金额: $ 14.17万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8853859
• 关键词: Acute; Address; Adipocytes; Adipose tissue; Adolescent; Adult; Affect; Aging; Blood Volume; Body Composition; Body Weight decreased; Body fat; Body mass index; Brown Fat; Cardiovascular Diseases; Cell Respiration; Characteristics; Chemicals; Child; Childhood; Classification; Clinical; Cluster Analysis; Comorbidity; Deoxyglucose; Detection; Development; Diabetes Mellitus; Diet; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; Epidemic; Fatty Liver; Fatty acid glycerol esters; Functional Magnetic Resonance Imaging; Generations; Goals; Heating; Histocompatibility Testing; Human; Image; Imaging Techniques; Incidence; Individual; Intervention; Ionizing radiation; Iron; Lipids; Liver diseases; Longitudinal Studies; Magnetic Resonance Imaging; Malignant Neoplasms; Mammals; Maps; Measurement; Measures; Metabolic; Methodology; Methods; Microscopic; Mitochondria; Monitor; Motion; Nonionizing Radiation; Obesity; Organ; Overweight; PET/CT scan; Physiological; Play; Positron-Emission Tomography; Property; Reference Standards; Relaxation; Research; Rodent; Role; Secondary to; Signal Transduction; Site; Structure; Thermogenesis; Time; Tissues; United States; Validation; Variant; Water; Weight; Work; X-Ray Computed Tomography; base; blood oxygen level dependent; body system; energy balance; falls; glucose metabolism; glucose uptake; imaging modality; indexing; novel; obesity treatment; public health relevance; response; young adult

DESCRIPTION (provided by applicant): Obesity has become an epidemic in the United States. More than one-third of U.S. adults (35.7%) are obese, and more than one third of children and adolescents are overweight or obese. Obesity affects all organ systems, increasing the incidence of diabetes, cardiovascular disease, cancer, fatty liver disease, and other co-morbidities. Obesity results from an imbalance between energy intake and expenditure. Exploring the role of adipose tissues in regulating energy balance is essential for understanding and treatment of obesity. There are two functionally different types of adipose tissues in mammals: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is the primary site for energy storage, whereas BAT is an adaptive thermogenesis organ that generates heat by energy expenditure. Recent research suggests that energy expenditure induced by active human BAT may play an important role in the adaption to weight loss. BAT activity is significantly higher in lean than obese individuals and the energy expenditure appears to increase in proportion to the amount of BAT activity. Overall, BAT activation is expected to serve as a potential target for obesity interventions. Identification of BAT after cold exposure with 18-Fluoro-deoxyglucose positron emission tomography computed tomography (FDG-PET/CT) imaging by monitoring glucose metabolism led to the discovery of the existence of metabolically active BAT in adult humans. Nevertheless, the utility of FDG-PET/CT for imaging human BAT is limited mainly due to its sensitivity to various body and environmental conditions, lack of tissue characterization in a cellular level and ionizing radiation exposure impeding longitudinal and pediatric studies. Magnetic Resonance Imaging (MRI) provides a non-ionizing radiation imaging modality that is now at the forefront in the assessment of body adipose tissues. Current MRI techniques are focused on differentiation between WAT and BAT; however, there is a lack of the characterization of BAT tissue properties within individuals, and the detection of tissue property changes secondary to BAT activation. Our goal is to develop multi-parametric quantitative MRI methods for BAT tissue characterization and tissue type classification. For the first time, we will implement quantitative MRI BAT imaging in both thermoneutral and cold-stimulated conditions to investigate the BAT microstructural tissue property changes due to cold activation in human. Furthermore, functional blood oxygenation level dependent (BOLD) MRI methods will be developed to investigate the tissue physiological changes in response to acute cold exposure. Cold-stimulated BAT activation map will be generated by both quantitative and functional MRIs. These novel MRI methods will provide information beyond structure and mass to functional measures that may reveal the metabolic and physiological functions of BAT.

描述（由申请人提供）：肥胖在美国已成为一种流行病。超过三分之一的美国成年人（35.7%）肥胖，超过三分之一的儿童和青少年超重或肥胖。肥胖影响所有器官系统，增加糖尿病、心血管疾病、癌症、脂肪肝和其他并发症的发病率。肥胖是由于能量摄入和消耗不平衡造成的。探索脂肪组织在调节能量平衡中的作用对于理解和治疗肥胖至关重要。哺乳动物有两种功能不同类型的脂肪组织：白色脂肪组织（WAT）和棕色脂肪组织（BAT）。 WAT是能量储存的主要场所，而BAT是一种适应性生热器官，通过能量消耗产生热量。最近的研究表明，活跃的人类 BAT 引起的能量消耗可能在适应减肥过程中发挥重要作用。瘦人的 BAT 活性明显高于肥胖者，并且能量消耗似乎与 BAT 活性量成比例增加。总体而言，BAT 激活有望成为肥胖干预的潜在目标。通过监测葡萄糖代谢，利用 18-氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描 (FDG-PET/CT) 成像来鉴定冷暴露后的 BAT，从而发现成年人体内存在代谢活跃的 BAT。然而，FDG-PET/CT 对人类 BAT 成像的实用性受到限制，主要是由于其对各种身体和环境条件的敏感性、缺乏细胞水平的组织特征以及电离辐射暴露阻碍了纵向和儿科研究。磁共振成像 (MRI) 提供了一种非电离辐射成像方式，目前处于身体脂肪组织评估的最前沿。目前的 MRI 技术主要集中于区分 WAT 和 BAT；然而，缺乏对个体内 BAT 组织特性的表征，以及对 BAT 激活继发的组织特性变化的检测。我们的目标是开发用于 BAT 组织表征和组织类型分类的多参数定量 MRI 方法。我们将首次在热中性和冷刺激条件下进行定量 MRI BAT 成像，以研究由于人体冷激活导致的 BAT 微观结构组织特性的变化。此外，还将开发功能性血氧水平依赖（BOLD）MRI 方法来研究急性冷暴露反应下的组织生理变化。冷刺激 BAT 激活图将通过定量和功能 MRI 生成。这些新颖的 MRI 方法将提供结构和质量之外的信息，以及可能揭示 BAT 代谢和生理功能的功能测量信息。

项目成果

MRI characterization of brown adipose tissue under thermal challenges in normal weight, overweight, and obese young men.

正常体重、超重和肥胖年轻男性在热挑战下棕色脂肪组织的 MRI 特征。

• 发表时间: 2018-04
• 作者: Deng, Jie;Neff, Lisa M;Rubert, Nicholas C;Zhang, Bin;Shore, Richard M;Samet, Jonathan D;Nelson, Paige C;Landsberg, Lewis
• 通讯作者: Landsberg, Lewis