CACHET - Environmental Biomarkers Core

CACHET - 环境生物标志物核心

• 批准号: 10641975
• 负责人: Eric G. Pamer
• 金额: $ 28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641975
• 关键词: Abbreviations; Address; Air; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Models; Blood; Chicago; Communities; Core Facility; Cost Sharing; Coupled; DNA; DNA sequencing; Data; Data Analyses; Data Reporting; Disease; Environment; Environmental Exposure; Environmental Health; Environmental Pollutants; Exposure to; Family; Feces; Fourier transform ion cyclotron resonance; Funding; Gas Chromatography; Genetic Predisposition to Disease; Genomics; Goals; Health; Heavy Metals; Herbicides; High Pressure Liquid Chromatography; Human Microbiome; Illinois; Inductively Coupled Plasma Mass Spectrometry; Institution; Investments; Liquid Chromatography; Liquid substance; MALDI-TOF Mass Spectrometry; Mass Spectrum Analysis; Measurement; Metagenomics; Mission; Monitor; National Institute of Environmental Health Sciences; Performance; Pesticides; Physiological; Plasma; Poison; Poly-fluoroalkyl substances; Population Dynamics; Predisposition; Proteomics; Reaction; Research; Research Personnel; Research Project Grants; Resources; Saliva; Sampling; Services; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Steroids; Time; Toxic Environmental Substances; Toxicogenomics; Universities; Volatile Fatty Acids; Water; analytical method; bisphenol A; cost effective; design; epigenomics; gene environment interaction; health inequalities; health science research; host microbiome; human subject; instrumentation; member; metabolomics; microbial; microbiome sequencing; microbiota; oxidation; research facility; small molecule; tandem mass spectrometry; transcriptomics; treatment response; ultra high pressure

1. ENVIRONMENTAL BIOMARKERS CORE (EBC): ABSTRACT The overall goal of the Environmental Biomarkers Core (EBC) is to provide bioanalytical services in support of ChicAgo Center for Health and EnvironmenT (CACHET) members conducting environmental health research at the University of Chicago (UofC) and University of Illinois at Chicago (UIC). By providing the necessary experimental expertise to assess a wide range of environmental biomarkers, the EBC directly contributes to CACHET’s mission to mitigate environmental health inequities within our communities. Toward that end, the EBC consists of two complimentary Sub-Cores: 1) a mass spectrometry-based Environmental Exposures Sub- Core that is P30-specific in services and resources available to members, and 2) a Biomarkers of Exposure Effects and Susceptibility Sub-Core that leverages existing institutional resources at UofC and UIC and streamlines services to members. The P30-specific Environmental Exposures Sub-Core at UIC will use mass spectrometry to assess toxic chemicals, heavy metals and metalloids, herbicides, pesticides, perfluoroalkyl substances, steroids and DNA oxidation products, among others, in both biological and environmental samples. New assays for environmental compounds will be developed and validated as needed by CACHET investigators. The Biomarkers of Exposure Effects and Susceptibility Sub-Core will leverage established institutional strengths in microbiome sequencing, metabolomics, proteomics, genomics, epigenomics and transcriptomics on the two campuses. Further, bioinformatics support for all CACHET PI-initiated research projects and Facility Core activities will be provided from established institutional cores at both partner institutions. For all of these services, CACHET members will enjoy priority access and subsidized rates for environmental health research projects provided by Center resources and leveraging institutional cost-sharing of intellectual expertise, management platforms and heavy investments in high-end instrumentation. These combined resources help address the EBC mission to provide qualitative and quantitative data regarding biomarkers of exposure, disease and therapeutic responses as well as levels of environmental contaminants in human subjects, model systems and environmental samples at subsidized rates and with priority access to Center members.

1。环境生物标志物核心（EBC）：摘要 环境生物标志物核心（EBC）的总体目标是提供生物分析服务以支持 芝加哥卫生与环境中心（CACHET）成员进行环境健康研究 芝加哥大学（UOFC）和伊利诺伊大学芝加哥大学（UIC）。通过提供必要的 实验专业知识以评估广泛的环境生物标志物，EBC直接有助于 Cachet的使命是减轻社区内环境健康不平等。为此， EBC由两个免费子核组成：1）基于质谱的环境暴露 核心特定于P30的服务和资源，以及2）曝光的生物标志物 在UOFC和UIC中利用现有机构资源的效果和敏感性子核心以及 简化成员的服务。 UIC的P30特异性环境暴露子核心将使用质量 评估有毒化学物质，重金属和金属，除草剂，农药，全氟烷基的光谱法 物质，类固醇和DNA氧化产物等在生物学和环境样品中。 CACHET调查人员将开发和验证环境化合物的新测定法。 暴露效果和易感性子核的生物标志物将利用已建立的机构优势 在微生物组测序，代谢组学，保护性，基因组学，表观基因组学和转录组学上 校园。此外，对所有Cachet PI引发的研究项目和设施核心的生物信息学支持 将从两个合作伙伴机构的既定机构核心提供活动。对于所有这些服务， CACHET成员将享受优先访问和环境健康研究项目的补贴费率 由中心资源提供并利用智力专业知识的机构成本分担 平台和高端仪器的大量投资。这些组合资源有助于解决EBC 提供有关暴露，疾病和治疗的生物标志物的定性和定量数据的使命 人类受试者，模型系统和 以补贴费率并优先访问中心成员的环境样本。