CACHET - Environmental Biomarkers Core

CACHET - 环境生物标志物核心

• 批准号: 10641975
• 负责人: Eric G. Pamer
• 金额: $ 28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641975
• 关键词: Abbreviations; Address; Air; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Models; Blood; Chicago; Communities; Core Facility; Cost Sharing; Coupled; DNA; DNA sequencing; Data; Data Analyses; Data Reporting; Disease; Environment; Environmental Exposure; Environmental Health; Environmental Pollutants; Exposure to; Family; Feces; Fourier transform ion cyclotron resonance; Funding; Gas Chromatography; Genetic Predisposition to Disease; Genomics; Goals; Health; Heavy Metals; Herbicides; High Pressure Liquid Chromatography; Human Microbiome; Illinois; Inductively Coupled Plasma Mass Spectrometry; Institution; Investments; Liquid Chromatography; Liquid substance; MALDI-TOF Mass Spectrometry; Mass Spectrum Analysis; Measurement; Metagenomics; Mission; Monitor; National Institute of Environmental Health Sciences; Performance; Pesticides; Physiological; Plasma; Poison; Poly-fluoroalkyl substances; Population Dynamics; Predisposition; Proteomics; Reaction; Research; Research Personnel; Research Project Grants; Resources; Saliva; Sampling; Services; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Steroids; Time; Toxic Environmental Substances; Toxicogenomics; Universities; Volatile Fatty Acids; Water; analytical method; bisphenol A; cost effective; design; epigenomics; gene environment interaction; health inequalities; health science research; host microbiome; human subject; instrumentation; member; metabolomics; microbial; microbiome sequencing; microbiota; oxidation; research facility; small molecule; tandem mass spectrometry; transcriptomics; treatment response; ultra high pressure

1. ENVIRONMENTAL BIOMARKERS CORE (EBC): ABSTRACT The overall goal of the Environmental Biomarkers Core (EBC) is to provide bioanalytical services in support of ChicAgo Center for Health and EnvironmenT (CACHET) members conducting environmental health research at the University of Chicago (UofC) and University of Illinois at Chicago (UIC). By providing the necessary experimental expertise to assess a wide range of environmental biomarkers, the EBC directly contributes to CACHET’s mission to mitigate environmental health inequities within our communities. Toward that end, the EBC consists of two complimentary Sub-Cores: 1) a mass spectrometry-based Environmental Exposures Sub- Core that is P30-specific in services and resources available to members, and 2) a Biomarkers of Exposure Effects and Susceptibility Sub-Core that leverages existing institutional resources at UofC and UIC and streamlines services to members. The P30-specific Environmental Exposures Sub-Core at UIC will use mass spectrometry to assess toxic chemicals, heavy metals and metalloids, herbicides, pesticides, perfluoroalkyl substances, steroids and DNA oxidation products, among others, in both biological and environmental samples. New assays for environmental compounds will be developed and validated as needed by CACHET investigators. The Biomarkers of Exposure Effects and Susceptibility Sub-Core will leverage established institutional strengths in microbiome sequencing, metabolomics, proteomics, genomics, epigenomics and transcriptomics on the two campuses. Further, bioinformatics support for all CACHET PI-initiated research projects and Facility Core activities will be provided from established institutional cores at both partner institutions. For all of these services, CACHET members will enjoy priority access and subsidized rates for environmental health research projects provided by Center resources and leveraging institutional cost-sharing of intellectual expertise, management platforms and heavy investments in high-end instrumentation. These combined resources help address the EBC mission to provide qualitative and quantitative data regarding biomarkers of exposure, disease and therapeutic responses as well as levels of environmental contaminants in human subjects, model systems and environmental samples at subsidized rates and with priority access to Center members.

1. 环境生物标志物核心 (EBC)：摘要 环境生物标志物核心 (EBC) 的总体目标是提供生物分析服务以支持 芝加哥健康与环境中心 (CACHET) 成员在以下地点进行环境健康研究 芝加哥大学 (UofC) 和伊利诺伊大学芝加哥分校 (UIC) 提供必要的材料。 EBC 凭借评估各种环境生物标志物的实验专业知识，直接做出了贡献 CACHET 的使命是减轻我们社区内的环境健康不平等现象。 EBC 由两个互补的子核心组成：1) 基于质谱的环境暴露子核心 会员可用的 P30 特定服务和资源的核心，以及 2) 暴露生物标志物 影响和敏感性子核心，利用 UofC 和 UIC 的现有机构资源， UIC 的 P30 特定环境暴露子核心将简化向会员提供的服务。 光谱法评估有毒化学品、重金属和类金属、除草剂、杀虫剂、全氟烷基 生物和环境样品中的物质、类固醇和 DNA 氧化产物等。 CACHET 研究人员将根据需要开发和验证环境化合物的新检测方法。 暴露效应和敏感性子核心的生物标志物将利用机构既定的优势 两者在微生物组测序、代谢组学、蛋白质组学、基因组学、表观基因组学和转录组学方面的研究 此外，为所有 CACHET PI 发起的研究项目和设施核心提供生物信息学支持。 对于所有这些服务，将由两个伙伴机构的既定机构核心提供活动。 CACHET 成员将享有环境健康研究项目的优先参与权和补贴率 由中心资源提供并利用知识专长、管理的机构成本分摊 平台和对高端仪器的大量投资，这些综合资源有助于解决 EBC。 使命是提供有关暴露、疾病和治疗生物标志物的定性和定量数据 人类受试者、模型系统和环境污染物的反应和水平 以补贴价格并优先向中心成员提供环境样品。