Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans

烟酰胺核苷对老年退伍军人功能能力和肌肉生理学的影响

• 批准号: 10642830
• 负责人: KENNETH LADD SELDEEN
• 金额: --
• 依托单位: KANSAS CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642830
• 关键词: Activities of Daily Living; Affect; Age; Age Years; Aging; Animals; Area; Biomass; Biopsy; Cardiovascular system; Cell Respiration; Cell physiology; Clinical; Clinical Trials; Cognition; Communities; Coupled; Data; Dementia; Double-Blind Method; Elderly; Exclusion; Exercise; Exhibits; Female; Fiber; Funding; Gait speed; Genus Hippocampus; Goals; Hand Strength; Health; Healthcare; Histologic; Histology; Hospitalization; Human; Impairment; Individual; Intramuscular; Link; Mediator; Messenger RNA; Mission; Mitochondria; Morphology; Mus; Muscle; Muscle Fibers; Muscle Mitochondria; Muscle function; Muscular Atrophy; Musculoskeletal; NADH; Nicotinamide adenine dinucleotide; Nutritional; Oxygen; Participant; Pathway Analysis; Performance; Persons; Physical Function; Physical Performance; Physical activity; Physiological; Placebos; Publishing; Publishing Peer Reviews; Quality of life; Randomized, Controlled Trials; Reporting; Research; Research Design; Resources; Risk; Safety; Serum; Signal Pathway; Signal Transduction; Skeletal Muscle; Supplementation; Syndrome; Telephone; Testing; Therapeutic; Time; VO2max; Veterans; Walking; Western Blotting; Woman; Work; actigraphy; aging population; biceps brachii muscle; cofactor; comorbidity; cost; differential expression; disability risk; extracellular; fall risk; frailty; health care service utilization; healthspan; human very old age (85+); improved; innovation; insight; men; mortality; muscle form; muscle physiology; muscle strength; muscular structure; nicotinamide riboside supplementation; nicotinamide-beta-riboside; novel; preclinical study; quadriceps muscle; recruit; resilience; response; restoration; sarcopenia; sex; stressor; study population; transcriptome sequencing; treadmill; uptake; vastus lateralis

Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Frailty is increasingly seen within the aging population and is driven largely by musculoskeletal declines. Nearly 9 million veterans are now 65 years of age or older with impairments in functional capacity, reduction in quality of life, and an increase in the use of health care services and associated costs. An estimated 45-50% of those over the age of 85 are frail, which could represent well over 1 million veterans. Aging, which significantly contributes to frailty, is highly correlated with reduced levels of nicotinamide adenine dinucleotide (NAD+), an essential mediator in mitochondrial function. Restoration of cellular NAD+ levels is gaining support as a therapeutic strategy to maintain and even enhance functional capacity during aging. Nicotinamide riboside (NR) - an NAD+ precursor - enhances physical activity and mitochondrial health in mice. Furthermore, NR was recently shown to be safe in human clinical trials for boosting NAD+, yet the benefits for human physical performance and muscle physiology are unknown. Therefore, the goal of this project is to establish a double-blind randomized control trial to assess the impacts of NR on functional capacity, muscle function and structure, and mRNA signaling in healthy older adults. Towards this goal, this study will investigate healthy older individuals between the ages of 65-85 who will receive NR or a placebo for a period of 3 months. Participants will be tested for frailty, gait speed, and muscle strength at each time point. Additionally, muscle biopsies and serum will be collected to assess changes in muscle fiber histology, mitochondrial biomass and activity, and mRNA profiles. This project will provide greater insight into NR supplementation as a therapeutic strategy to stave off frailty and maintain resilience during aging. HIIT enhances physical performance and reduces frailty during aging.

烟酰胺核苷对老年退伍军人功能能力和肌肉生理的影响 在衰老中越来越脆弱 人口，主要由肌肉骨骼下降驱动。 现在将近900万退伍军人年龄在65岁以上 功能障碍，质量降低 生活，以及医疗服务的使用增加 相关费用。估计超过年龄的人中有45-50％ 85是脆弱的，可能代表超过100万 退伍军人。衰老大大导致脆弱的衰老是 与烟酰胺水平降低高度相关 腺嘌呤二核苷酸（NAD+），这是一个必需的介体 线粒体功能。恢复细胞NAD+水平是 获得支持作为维护和维持的治疗策略 甚至在衰老期间提高功能能力。烟酰胺 核苷（NR） - NAD+前体 - 增强物理 小鼠的活性和线粒体健康。此外，NR 最近被证明在人类的临床试验中是安全的 增强NAD+，但是人类身体表现和肌肉生理的好处是 未知。因此，该项目的目的是建立一项双盲随机控制试验 评估NR对功能能力，肌肉功能和结构以及mRNA信号的影响 健康的老年人。为了实现这一目标，这项研究将调查健康的老年人 65-85岁的年龄将在3个月内接受NR或安慰剂。参与者将接受测试 在每个时间点，脆弱，步态速度和肌肉力量。另外，肌肉活检和精华素 将收集以评估肌肉纤维组织学，线粒体生物量和活性的变化，以及 mRNA轮廓。该项目将提供对NR补充作为治疗性的更深入的洞察力 在衰老期间避免脆弱并保持韧性的策略。 HIIT增强了身体表现 并减少衰老期间的脆弱性。