Postdoctoral Training Program in Genomic Medicine

基因组医学博士后培养项目

• 批准号: 10642810
• 负责人: PATRICIA I DICKSON
• 金额: $ 18.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642810
• 关键词: Genomic medicine; Training Programs; post-doctoral training

PROJECT SUMMARY/ABSTRACT This is an application for a new Postdoctoral Training Program in Genomic Medicine (T32). We propose two postgraduate positions per year to support physician-scientists who are engaging in medical genetics research. There are too few medical geneticists to meet the growing need for our services. As a result, much of medical genetics testing, diagnosis, counseling, and management occurs outside of our field and is instead practiced by physicians who receive little specific training. Our goals are therefore twofold: first, to mentor future medical geneticists who are embarking on a career in academic medicine and therefore grow the medical genetics workforce; and secondly, to provide medical genetics training to physician-scientists in other fields who engage in medical genetics-related research, which will enhance the clinical knowledge-base of those specialists who may be most likely to use genetic testing or treatments in their practices. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators performing research in medical genetics within the Washington University School of Medicine, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics 3) individualized specific coursework based on the trainees’ areas of investigation, 4) continuous feedback to the trainees, mentors and program leadership, and 5) the development of trainees with disabilities, disadvantaged backgrounds, and underrepresented minorities. Trainees may choose from four focus areas, which represent patient care needs with particularly rapid growth: Cancer, Rare and Undiagnosed Diseases, Gene-Environment Interaction, and Neurodegeneration. The program director, Patricia Dickson, will work closely with co-director Jorge Di Paola to select and oversee training of future leaders in genomic medicine. Major strengths of this program include active medical and laboratory genetics training programs, in- house clinical cytogenetics laboratory, biochemical laboratory, and sequencing capability, a large number of centers and groups performing genomic studies, including Undiagnosed Diseases Network clinical and model organism screening center sites, the McDonnell Genome Institute, the Cancer Atlas Network, the Edison Family Center for Genome Sciences & Systems Biology, and others. Washington University provides an outstanding mentorship environment and infrastructure for genetics research, with an emphasis on collaboration and a superb track record of producing physician-scientists. This proposal will take advantage of the wealth of genetics research, clinical and research training, and mentorship that is thriving on our campus to train those scientists who will bring innovative diagnostics, therapeutics, and data-driven practice to the clinic.

项目摘要/摘要 这是针对基因组医学的新博士后培训计划（T32）的应用程序。我们提出了两个 每年的研究生职位支持从事医学遗传学研究的身体科学家。 医疗硕士太少了，无法满足我们服务日益增长的需求。结果，大部分医疗 遗传学测试，诊断，咨询和管理发生在我们领域之外，而是实践 由几乎没有特定培训的医生。因此，我们的目标是双重的：首先是心理未来的医疗 从事学术医学职业并因此发展医学遗传学的遗传学家 劳动力；其次，向其他领域的身体科学家提供医学遗传学培训 在与医学遗传学相关的研究中，这将增强那些专家的临床知识基础 可能最有可能在其实践中使用基因检测或治疗方法。该提议的具体目的 包括：1）受保护的指导研究经验，与成熟的研究人员进行研究 华盛顿大学医学院内的医学遗传学，2） 实验室管理，科学严谨，统计，授予技巧，负责任的研究以及 生物医学信息3）基于培训的投资领域的个性化特定课程，4） 持续向学员，导师和计划领导的反馈，以及5）与学员的发展 残疾，处境不利的背景和代表性不足的少数民族。学员可以从四个选择 焦点领域，代表患者护理需求特别快速生长：癌症，罕见和未诊断 疾病，基因环境相互作用和神经退行性。计划主任帕特里夏·迪克森（Patricia Dickson）将 与联合导演豪尔赫·迪·保罗（Jorge Di Paola）紧密合作，以选择和监督基因组未来领导者的培训 药品。该计划的主要优势包括活跃的医疗和实验室遗传学培训计划， 房屋临床细胞遗传学实验室，生化实验室和测序能力，大量 进行基因组研究的中心和小组，包括未诊断的疾病网络临床和模型 生物体筛查中心地点，麦当劳基因组研究所，癌症地图集网络，爱迪生 基因组科学与系统生物学的家庭中心等。华盛顿大学提供 遗传学研究的杰出精明环境和基础设施，重点是 协作和生产身体科学家的出色记录。该建议将利用 遗传学研究，临床和研究培训以及在我们校园里蓬勃发展的心态 培训那些将为诊所带来创新诊断，治疗和数据驱动实践的科学家。