Shape Memory Polymer Foams for Hemorrhage Control in Traumatic Wounds

用于控制外伤出血的形状记忆聚合物泡沫

• 批准号: 10638377
• 负责人: Michaela Christina Kollisch-Singule
• 金额: $ 18.73万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10638377
• 关键词: Address; Affect; Aftercare; Analgesics; Animals; Architecture; Biocompatible Materials; Blood; Body Temperature; Cellulose; Cessation of life; Chitosan; Clinical; Coagulation Process; Data; Device Designs; Devices; Dryness; European Union; Excision; Exposure to; Family suidae; Fibrin; Focal Infection; Future; Future Generations; Goals; Gunshot wound; Heating; Hemorrhage; Hemostatic Agents; Hemostatic function; High temperature of physical object; Hospitals; Hour; Human; In Vitro; Injury; Japan; Limb structure; Liver; Memory; Mission; Modeling; Monitor; Outcome; Patients; Peripheral Vascular Diseases; Polymers; Porosity; Property; Public Health; Research; Safety; Shapes; Site; Sterile coverings; System; Techniques; Time; Tissues; Tourniquets; Training; Trauma; United States; United States Food and Drug Administration; United States National Institutes of Health; Water; Work; Wound models; antimicrobial; biomaterial compatibility; clinical translation; clinically relevant; combat; design; expectation; femoral artery; implantation; improved; improved outcome; in vivo; infection risk; liver injury; pre-clinical; pressure; remote location; survival outcome; traumatic wound; wound

PROJECT SUMMARY/ABSTRACT Uncontrolled hemorrhage is the primary cause of trauma-related death, and approximately half of hemorrhage deaths occur before the patient reaches the hospital. Current techniques for hemorrhage control are insufficient for a large number of wounds and do not adequately address non-compressible hemorrhages. Thus, there is a critical need for improved hemostatic dressing materials that are inexpensive, easy to apply, effective, and safe to use over prolonged time frames. In the absence of such treatment options, tragic deaths from uncontrolled bleeding will continue. The long-term goal of the proposed work is to provide an accessible option for hemorrhage control that can be used with minimal training in remote situations. The overall objectives in this application are to characterize efficacy of a promising biomaterial platform, shape memory polymer (SMP) foams, in clinically-relevant hemorrhage models and to develop easy-to-use storage and delivery devices. In preliminary work in a porcine grade V liver injury, SMP foam treatment provided faster hemostasis, reduced total blood loss, and improved survival relative to treatment with clinical controls. The rationale for the proposed work is that future clinical translation efforts will be enabled by an improved understanding of how foam properties affect hemorrhage control and expanded pre-clinical characterization of this promising platform. To achieve these objectives, the following specific aims will be pursued: Specific Aim 1: Evaluate effects of SMP foam architectures on hemorrhage control in in vitro wound models, and design storage and delivery devices for non-compressible torso wounds and compressible extremity wounds. Specific Aim 2: Characterize SMP foam efficacy in vivo in a non-compressible grade V liver injury. Specific Aim 3: Characterize SMP foam application, efficacy, removal, and safety in vivo in a compressible femoral artery injury. At the completion of these studies, the expectation is to have clinically-relevant SMP foam- based hemostatic device designs for use in compressible and non-compressible traumatic wounds. The primary positive impact of these studies will be a hemostatic dressing that is easy- to-use and effective in a range of hemorrhagic wound types.

项目摘要/摘要 不受控制的出血是创伤相关死亡的主要原因，大约 一半的出血死亡发生在患者到达医院之前。当前技术 出血控制不足以用于大量伤口，并且不能充分解决 不可压缩的出血。因此，迫切需要改善止血性敷料 较便宜，易于应用，有效且安全使用的材料长时间使用 帧。在没有这种治疗方案的情况下，不受控制的出血死亡将会 继续。 拟议工作的长期目标是为出血提供可及的选择 可以在远程情况下最少培训的控制。其中的总体目标 应用是为了表征有希望的生物材料平台的功效，形状记忆 聚合物（SMP）泡沫，在临床上相关的出血模型中，并开发易于使用 存储和交付设备。在猪级V肝损伤的初步工作中，SMP泡沫 治疗提供了更快的止血，减少总失血以及相对于 用临床对照治疗。拟议工作的理由是未来的临床 通过对泡沫属性的影响，将对翻译工作进行改进 该有前途的平台的出血控制和扩展的临床前表征。 为了实现这些目标，将实现以下具体目标： 特定目标1：评估SMP泡沫结构对体外出血控制的影响 伤口型号，以及设计不可压缩躯干伤口的存储和交付设备 可压缩的肢体伤口。 特定目标2：表征不可压缩级肝脏中体内SMP泡沫功效 受伤。 特定目的3：表征SMP泡沫应用，疗效，删除和安全性的体内安全性 可压缩的股动脉损伤。 这些研究完成时，期望是具有临床上与SMP相关的泡沫 - 基于止血装置设计，用于可压缩和不可压缩的创伤 伤口。这些研究的主要积极影响是一种容易的止血性敷料 在各种出血性伤口类型中有效且有效。