T32 for Training in Microbiology and Infectious Diseases

T32 用于微生物学和传染病培训

基本信息

批准号：
10640896
负责人：
Celia Goulding
金额：
$ 14.1万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-19 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10640896
关键词：
Communicable Diseases Microbiology Training

项目摘要

PROJECT SUMMARY This proposal is a new application for five years of funding to support Training in Microbiology and Infectious Diseases at UC Irvine. The primary objective of this Training Program is to provide doctoral students with integrated training in three focus areas: 1) microbial structure and metabolism, 2) microbe- host interactions, and 3) microbial communities. The rationale behind this training structure is that there will be tremendous value in individuals with a fluency in these related areas that are vital to combating and/or exploiting microbes to positively impact human health and the environment. The Training Program will leverage areas of excellence at UCI in microbial ecology, microbe-host interactions, and structural biology to bring together faculty trainers with expertise in microbial pathogenesis, molecular genetics, metabolism, structure, immunity and infectious diseases, and microbial diversity. The program will be comprised of 18 well-funded training faculty (10 women, 8 men) from the School of Biological Sciences and the School of Medicine at UCI. The faculty mentors conduct research on microbiology and infectious diseases at the molecular, cellular, organismal, population, and community levels. UCI has a strong history in the fields of microbiology and infectious disease research, as the Pacific-Southwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases was housed at UCI from 2005- 2014. The Training Program will ensure that the trainees will be equipped with the necessary tools and expertise to pursue a productive and independent career in microbiology. In addition to faculty mentorship, the trainees will benefit from seminars, journal clubs, research in progress talks, and an annual symposium. Trainees will also receive funds to travel to and present their research at a national meeting in their field. Finally, UCI is home to the NIH-funded GPS-BIOMED program, which will ensure that trainees have exposure to career development seminars, workshops, and mentorship throughout their training. The application requests support for three predoctoral trainees, who will be drawn from students who enroll at UCI through one of several gateway or departmental programs, including the Cellular & Molecular Biosciences Program, Interdepartmental Neuroscience Program, Mathematical, Computational & Systems Biology Program, Medical Scientist Training Program (MSTP), and the departmental Ecology & Evolutionary Biology Program. The mean incoming GPA for this cohort of students over the last five years was 3.61, reflecting a strong overall academic performance by the potential trainees. On average over the last five years, 23% of the training-grant eligible entering students were under-represented minorities. UCI has been recognized as a Hispanic-serving institution (HSI) and an Asian American, Native American, and Pacific Islander serving institution (AANAPISI), and the Training Program is expected to reflect this rich cultural and ethnic diversity on the UCI campus.

项目概要该提案是一项新的五年资助申请，用于支持微生物学和加州大学欧文分校的传染病该培训计划的主要目标是提供博士学位。学生在三个重点领域接受综合培训：1) 微生物结构和代谢，2) 微生物宿主相互作用，以及 3）微生物群落。这种训练结构背后的基本原理是：对于精通这些对打击至关重要的相关领域的个人来说将具有巨大的价值和/或利用微生物对人类健康和环境产生积极影响。培训计划。将利用 UCI 在微生物生态学、微生物-宿主相互作用和结构方面的卓越领域生物学将具有微生物发病机制、分子遗传学、该计划将包括新陈代谢、结构、免疫和传染病以及微生物多样性。由来自生物科学学院的 18 名资金雄厚的培训教师（10 名女性，8 名男性）组成和加州大学尔湾分校医学院的导师们进行微生物学和传染病方面的研究。 UCI 在分子、细胞、器质性、群体和群落水平上对疾病有很强的研究能力。作为太平洋西南地区的微生物学和传染病研究领域的历史生物防御和新兴传染病卓越中心自 2005 年起设在 UCI 2014年。培训计划将确保受训人员配备必要的工具和除了教师之外，还拥有在微生物学领域追求富有成效和独立的职业生涯的专业知识。在指导下，学员将受益于研讨会、期刊俱乐部、正在进行的研究讲座和年度研讨会还将获得资助，用于前往全国性研讨会并展示他们的研究成果。最后，UCI 是 NIH 资助的 GPS-BIOMED 项目的所在地，这将确保学员可以在整个过程中参加职业发展研讨会、讲习班和指导。该申请要求为三名博士前实习生提供支持，他们将从中抽取。通过多个网关或院系项目之一入读 UCI 的学生，包括细胞与分子生物科学项目、跨部门神经科学项目、数学、计算与系统生物学项目、医学科学家培训项目 (MSTP) 以及该群体的系生态学和进化生物学项目的平均 GPA。过去五年的学生得分为 3.61，反映出该校整体学术表现强劲过去五年平均有 23% 的培训补助金符合资格进入。 UCI 被认为是一所为西班牙裔服务的机构。 (HSI) 和亚裔美国人、美洲原住民和太平洋岛民服务机构 (AANAPISI)，以及培训计划预计将反映 UCI 校园丰富的文化和种族多样性。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High-Fiber, Whole-Food Dietary Intervention Alters the Human Gut Microbiome but Not Fecal Short-Chain Fatty Acids.

DOI：
10.1128/msystems.00115-21
发表时间：
2021-03-16
期刊：
mSystems
影响因子：
6.4
作者：
Oliver A;Chase AB;Weihe C;Orchanian SB;Riedel SF;Hendrickson CL;Lay M;Sewall JM;Martiny JBH;Whiteson K
通讯作者：
Whiteson K

Global scale phylogeography of functional traits and microdiversity in Prochlorococcus.

DOI：
10.1038/s41396-023-01469-y
发表时间：
2023-10
期刊：
ISME JOURNAL
影响因子：
11
作者：
Ustick, Lucas J.;Larkin, Alyse A.;Martiny, Adam C.
通讯作者：
Martiny, Adam C.

Linking regional shifts in microbial genome adaptation with surface ocean biogeochemistry

DOI：
10.1098/rstb.2019.0254
发表时间：
2020-05-11
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
影响因子：
6.3
作者：
Garcia, Catherine A.;Hagstrom, George, I;Martiny, Adam C.
通讯作者：
Martiny, Adam C.

Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.

DOI：
10.15252/emmm.202013818
发表时间：
2021-11-08
期刊：
EMBO molecular medicine
影响因子：
11.1
作者：
Gaillard N;Sharma A;Abbaali I;Liu T;Shilliday F;Cook AD;Ehrhard V;Bangera M;Roberts AJ;Moores CA;Morrissette N;Steinmetz MO
通讯作者：
Steinmetz MO

Metagenomic analysis reveals global-scale patterns of ocean nutrient limitation