Senior Research Career Scientist

高级研究职业科学家

• 批准号: 10640861
• 负责人: Russell S. Richardson
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640861
• 关键词: Acceleration; Age; Age Years; Aging; Alzheimer' s Disease; American; American Heart Association; Area; Attenuated; Award; Biological Sciences; Blood Vessels; Businesses; California; Cardiology; Cities; Clinical Research; Cognition; Coupled; Critical Care; Data; Development; Disease; Doctor of Philosophy; Education; Elderly; England; Extensor; Faculty; Fatigue; Functional disorder; Funding; Geriatrics; Goals; Grant; Health; Healthcare; Healthcare Systems; Immobilization; Impairment; Individual; Institution; Journals; Laboratory Research; Leg; Link; London; Long-Term Care; Lower Extremity; Lung; Mediating; Mediation; Medical Research; Medicine; Mentors; Mentorship; Metabolic; Metabolic Control; Mission; Muscle; Muscular Atrophy; Paper; Peer Review; Persons; Physical Capacity; Physical Function; Physiological; Physiology; Play; Population; Postdoctoral Fellow; Process; Production; Productivity; Publishing; Rehabilitation therapy; Research; Research Priority; Resistance; Role; Scientist; Services; Skeletal Muscle; Societies; Sodium Chloride; Students; Training; United States National Institutes of Health; Universities; Utah; Vascular Diseases; Veterans; Viscosity; Walking; Work; age related; aged; care costs; career; clinical center; clinically relevant; college; deconditioning; demographics; fall risk; frailty; indexing; interest; military veteran; professor; programs; recruit; rehabilitation research; research and development; respiratory; walking speed

Abstract: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength and power can become mobility-limited to a degree that simply walking to the mailbox is at the upper limit of their physical capacity. An age-associated vascular dysfunction leading to muscle de-conditioning, particularly in the lower extremities, has been described as a “vicious loop” as inactivity and muscle atrophy result in weakness and low power production which leads to reduced mobility and an even greater restriction of activity leading to even more pronounced vascular and muscle deterioration. The central goal of Dr. Richardson’s research is to attenuate the process of vascular aging such that fatigue resistance and impaired mobility are achieved and vascular aging continues to be attenuated. Thus, Dr. Richardson’s work has significant implications for the VA and rehabilitative medicine. Due to Dr. Richardson’s research interests, related to the vascular and metabolic changes associated with the aging process, he was recruited from the Division of Physiology, at the University of California, San Diego, in 2007 to the University of Utah, Division of Geriatrics, and the Salt Lake City Geriatrics, Research, Education, and Clinical Center (GRECC), as a Professor and Associate Director for Research, respectively. In 2015 Dr. Richardson received a VA Rehabilitation Research Service, Senior Research Career Scientist (SRCS) Award and the current application represents his request to renew this award. Since, receiving the SRCS Award, in 2015, Dr. Richardson has published over 110 papers disseminating his research in good peer reviewed journals. Dr. Richardson has worked on a wide variety of integrative physiologic studies for almost 30 years, and, as of now, he has published almost 300 papers, has an h-index of 69, and his work has been cited well over 16,000 times. In recognition of Dr. Richardson’s contributions to the field, in 2018, he was Awarded an Honorary Doctorate, in Biological Sciences, from his alma mater, Brunel University in London England. Currently, he is the PI of two VA RR&D Merit Awards, one focusing on the role of the vasculature in Alzheimer’s Disease and the other developing a promising, clinically relevant, assessment of vascular health. He is the Co-I on another RR&D funded Merit and a CSR&D funded Merit as well as two NIH funded R01s. Additionally, Dr. Richardson has successfully mentored well over 40 people at the Graduate, Post-Doctoral, and Faculty levels, as evidenced by the fact that he is currently the PI of NIH T32 Institutional Training Grant entitled Cardiovasomobility (and a mentor on two other T32s, Cardiology and Pulmonary), a Co-I of an American Heart Association Institutional Training Grant, and is just embarking on the mentorship of his third VA CDA2 recipient. Dr. Richardson is now in his 14th year as full time VA scientist and is keen to carry on his work for the VA and the RR&D Service with continued support through the SRCS Award mechanism.

抽象的： 退伍军人人口年龄分布不均，超过 55% 的退伍军人年龄已超过 65 岁 肌肉尺寸、力量和力量存在缺陷的老年人可能会在一定程度上限制活动能力。 仅仅走到邮箱就已经达到了他们的物理能力的上限。 导致肌肉失调（尤其是下肢）的功能障碍被描述为 “恶性循环”，因为不活动和肌肉萎缩会导致虚弱和低功率产生，从而导致 活动能力降低，活动受到更大限制，导致血管和肌肉更加明显 理查森博士研究的中心目标是减轻血管老化的过程。 实现了抗疲劳和行动能力受损，并且血管老化持续减弱。 理查森博士的工作对退伍军人管理局和康复医学具有重大影响。 他的研究兴趣与衰老过程相关的血管和代谢变化有关 2007年从加州大学圣地亚哥分校生理学系招募到加州大学圣地亚哥分校 犹他州老年病科和盐湖城老年病学、研究、教育和临床中心 （GRECC），分别担任教授和研究副主任。 2015 年，理查森博士获得了 VA 康复研究服务，高级研究职业科学家 (SRCS) 奖和当前 自 2015 年获得 SRCS 奖以来，该申请代表了他续签该奖项的请求。 Richardson 博士在优秀的同行评审期刊上发表了 110 多篇论文，传播了他的研究成果。 Richardson 从事各种综合生理学研究近 30 年，到目前为止， 他发表了近 300 篇论文，H 指数为 69，他的作品被引用超过 16,000 次。 为了表彰理查森博士对该领域的贡献，2018 年，他被授予荣誉博士学位， 其母校英国伦敦布鲁内尔大学生物科学系目前是两个项目的 PI。 VA RR&D 优异奖，一个关注血管系统在阿尔茨海默氏病中的作用，另一个关注于血管系统在阿尔茨海默病中的作用 他是另一项 RR&D 的 Co-I。 Richardson 博士还获得了一项 CSR&D 资助的 Merit 以及两项 NIH 资助的 R01。 成功指导了 40 多名研究生、博士后和教师级别的人员，证据如下： 事实上，他目前是 NIH T32 机构培训补助金的 PI，该补助金名为“心血管流动性”（以及 另外两个 T32（心脏病​​学和肺科）的导师，美国心脏协会机构的 Co-I 培训补助金，现在刚刚开始指导他的第三位 VA CDA2 获得者理查森博士。 今年是他担任 VA 全职科学家的第 14 个年头，他热衷于继续为 VA 和 RR&D 服务部门开展工作 通过 SRCS 奖励机制继续提供支持。