Senior Research Career Scientist

高级研究职业科学家

• 批准号: 10640861
• 负责人: Russell S. Richardson
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640861
• 关键词: Acceleration; Age; Age Years; Aging; Alzheimer' s Disease; American; American Heart Association; Area; Attenuated; Award; Biological Sciences; Blood Vessels; Businesses; California; Cardiology; Cities; Clinical Research; Cognition; Coupled; Critical Care; Data; Development; Disease; Doctor of Philosophy; Education; Elderly; England; Extensor; Faculty; Fatigue; Functional disorder; Funding; Geriatrics; Goals; Grant; Health; Healthcare; Healthcare Systems; Immobilization; Impairment; Individual; Institution; Journals; Laboratory Research; Leg; Link; London; Long-Term Care; Lower Extremity; Lung; Mediating; Mediation; Medical Research; Medicine; Mentors; Mentorship; Metabolic; Metabolic Control; Mission; Muscle; Muscular Atrophy; Paper; Peer Review; Persons; Physical Capacity; Physical Function; Physiological; Physiology; Play; Population; Postdoctoral Fellow; Process; Production; Productivity; Publishing; Rehabilitation therapy; Research; Research Priority; Resistance; Role; Scientist; Services; Skeletal Muscle; Societies; Sodium Chloride; Students; Training; United States National Institutes of Health; Universities; Utah; Vascular Diseases; Veterans; Viscosity; Walking; Work; age related; aged; care costs; career; clinical center; clinically relevant; college; deconditioning; demographics; fall risk; frailty; indexing; interest; military veteran; professor; programs; recruit; rehabilitation research; research and development; respiratory; walking speed

Abstract: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength and power can become mobility-limited to a degree that simply walking to the mailbox is at the upper limit of their physical capacity. An age-associated vascular dysfunction leading to muscle de-conditioning, particularly in the lower extremities, has been described as a “vicious loop” as inactivity and muscle atrophy result in weakness and low power production which leads to reduced mobility and an even greater restriction of activity leading to even more pronounced vascular and muscle deterioration. The central goal of Dr. Richardson’s research is to attenuate the process of vascular aging such that fatigue resistance and impaired mobility are achieved and vascular aging continues to be attenuated. Thus, Dr. Richardson’s work has significant implications for the VA and rehabilitative medicine. Due to Dr. Richardson’s research interests, related to the vascular and metabolic changes associated with the aging process, he was recruited from the Division of Physiology, at the University of California, San Diego, in 2007 to the University of Utah, Division of Geriatrics, and the Salt Lake City Geriatrics, Research, Education, and Clinical Center (GRECC), as a Professor and Associate Director for Research, respectively. In 2015 Dr. Richardson received a VA Rehabilitation Research Service, Senior Research Career Scientist (SRCS) Award and the current application represents his request to renew this award. Since, receiving the SRCS Award, in 2015, Dr. Richardson has published over 110 papers disseminating his research in good peer reviewed journals. Dr. Richardson has worked on a wide variety of integrative physiologic studies for almost 30 years, and, as of now, he has published almost 300 papers, has an h-index of 69, and his work has been cited well over 16,000 times. In recognition of Dr. Richardson’s contributions to the field, in 2018, he was Awarded an Honorary Doctorate, in Biological Sciences, from his alma mater, Brunel University in London England. Currently, he is the PI of two VA RR&D Merit Awards, one focusing on the role of the vasculature in Alzheimer’s Disease and the other developing a promising, clinically relevant, assessment of vascular health. He is the Co-I on another RR&D funded Merit and a CSR&D funded Merit as well as two NIH funded R01s. Additionally, Dr. Richardson has successfully mentored well over 40 people at the Graduate, Post-Doctoral, and Faculty levels, as evidenced by the fact that he is currently the PI of NIH T32 Institutional Training Grant entitled Cardiovasomobility (and a mentor on two other T32s, Cardiology and Pulmonary), a Co-I of an American Heart Association Institutional Training Grant, and is just embarking on the mentorship of his third VA CDA2 recipient. Dr. Richardson is now in his 14th year as full time VA scientist and is keen to carry on his work for the VA and the RR&D Service with continued support through the SRCS Award mechanism.

抽象的： 退伍军人人口偏向年龄，超过65岁的退伍军人中有超过55％ 年龄。具有肌肉大小，力量和力量定义的老年人可以在一定程度上变得有限 简单地步行到邮箱处于其身体容量的上限。与年龄相关的血管 功能障碍导致肌肉去解决方案，特别是在下肢中，已被描述为 “恶性循环”作为无活动和肌肉萎缩会导致无力和低功率产生，从而导致 降低了活动能力，对活动的限制更大，导致血管和肌肉更明显 恶化。理查森博士的研究的核心目标是减轻这种血管衰老的过程 达到疲劳性和迁移率受损，血管衰老继续被减弱。那， 理查森博士的工作对VA和康复医学具有重要意义。由于理查森博士 研究兴趣与与衰老过程相关的血管和代谢变化有关，他是 2007年从加利福尼亚大学圣地亚哥分校的生理学系招募到大学 犹他州，老年医学师以及盐湖城的老年病，研究，教育和临床中心 （GRECC），分别担任研究教授兼副主任。 2015年，理查森博士收到了 VA康复研究服务，高级研究职业科学家（SRCS）奖和当前 申请代表了他要求续签该奖项的请求。此后，2015年获得了SRCS奖，博士 理查森（Richardson）发表了110多篇论文，在良好的同行评审期刊上发表了他的研究。博士 理查森（Richardson）从事各种综合生理学研究已有近30年的历史，到目前为止， 他发表了将近300篇论文，H-Index为69，他的作品被引用了超过16,000次。 为了认可理查森博士对该领域的贡献，2018年，他被授予荣誉博士学位 来自伦敦英国布鲁内尔大学的母校的生物科学。目前，他是两个 VA RR＆D值得一提的奖项，一个侧重于脉管系统在阿尔茨海默氏病中的作用，另一种是 开发有前途的，临床上相关的血管健康评估。他是另一个RR＆D上的Co-I 资助的绩效和CSR＆D资助的功绩以及两个NIH资助的R01。此外，理查森博士有 在毕业生，博士后和教职员工级别上，有40多人的推荐人数超过40人 他目前是NIH T32机构培训赠款的事实，名为Cardiovaasomability（和A Menor在另外两个T32，心脏病学和肺部），美国心脏协会机构的一家 培训赠款，只是启动他的第三个VA CDA2接收者的心态。理查森博士现在 在他担任全职VA科学家的第14年，他渴望在VA和RR＆D服务中继续工作 通过SRCS奖机制继续支持。