Pathways to Lower Urinary Tract Symptoms Prevention in Adolescent and Adult Women.

预防青少年和成年女性降低尿路症状的途径。

基本信息

批准号：
10455099
负责人：
Alayne Denise Markland
金额：
$ 25万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10455099
关键词：
Activities of Daily Living Address Adolescent Adolescent Medicine Adult Affect Age Alabama Area Behavior Behavioral Medicine Biological Biological Markers Biometry Bladder Clinical Research Collection Communities Data Coordinating Center Detection Development Education Environment Epidemiology Evaluation Exercise Foundations Future Gait speed Geographic Information Systems Geriatrics Goals Health Health Sciences Health Services Research Health education Home environment Human Resources Increased frequency of micturition Individual Intervention Intervention Studies Knowledge Life Cycle Stages Literature Longitudinal Studies Longitudinal cohort study Measures Medical Sociology Methodology Modeling Nocturia Occupational Pain Participant Pathway interactions Personal Satisfaction Persons Policies Population Heterogeneity Prevention Psyche structure Public Health Qualitative Methods Research Research Methodology Research Personnel Research Project Grants Risk Risk Factors Role Sampling Schools Science Severities Social Well-Being Specimen Symptoms Testing Time Travel Universities Urethra Urinary Incontinence Urinary tract infection Urination Woman bladder pain clinical examination cohort community based participatory research community engagement deprivation design environmental stressor epidemiology study health disparity improved indexing inflammatory marker lower urinary tract symptoms mHealth mHealth self-management member micturition urgency mobile application model development neighborhood association neighborhood disadvantage novel physical state prevent preventive intervention programs protective factors recruit response social teacher young woman

项目摘要

PROJECT SUMMARY/ABSTRACT Lower urinary tract symptoms (LUTS) encompass a wide range of symptoms, including urinary incontinence, urinary frequency, urgency, nocturia, bladder pain, urinary tract infections, and voiding symptoms. There is an extensive literature describing the many approaches to treatment of LUTS, but less is known about prevention. The “Prevention of Lower Urinary Tract Symptoms (PLUS) Consortium is a transdisciplinary scientific network established to expand research beyond the treatment of LUTS to promotion of bladder health and prevention of LUTS in adolescents and women across the life course. Despite many epidemiologic studies on risk factors for LUTS, little research has examined factors that promote bladder health. One key gap is in understanding of what defines healthy voiding and toileting behaviors and how these behaviors affect bladder health over time. Our overarching hypothesis is that maladaptive voiding and toileting behaviors contribute to poorer bladder health among adolescent and adult women. The primary aim of this proposal is to continue our participation as a clinical research center in PLUS and collaborate with other centers to design and conduct a longitudinal cohort study that lays the foundation for developing future prevention interventions to promote bladder health and prevent LUTS. The University of Alabama at Birmingham (UAB) team is an interdisciplinary group of investigators with collective expertise in LUTS clinical research, behavioral medicine, geriatric medicine, adolescent medicine, prevention science, public health, epidemiology, biostatistics, health disparities, and medical sociology. Our team is poised to contribute expertise on 1) design and conduct of longitudinal studies, 2) evaluation and treatment of LUTS (including clinical examination and bio-specimen collection), 3) qualitative methods, 4) recruitment and retention of diverse samples of participants with/without LUTS, and 5) community engagement. The second aim is to build on the longitudinal cohort study to examine two additional potential risk/protective factors for bladder health and LUTS that are plausible targets for future intervention studies. In addition to testing a number of other factors in the national cohort, we propose to examine 1) the role of neighborhood disadvantage in relation to voiding and toileting behaviors, using the Area Deprivation Index, and 2) the association of functional ability with voiding and toileting behaviors using gait speed and bio-markers of inflammation. Understanding the role of these factors will support the development of models for identifying at- risk individuals and groups, as well as inform education initiatives. The third aim is to develop and conduct pilot foundational studies related to promoting healthy voiding and toileting behaviors. The first study aims to understand voiding and toileting behaviors across environments among adolescents using a mobile application with geographic information system mapping. The second aims to develop a mobile health self-management educational program for promoting healthy bladder behaviors. These projects will lay the foundation for the development of future research on interventions to promote bladder health across the life course.

项目摘要/摘要较低的尿路症状（LUTS）包括各种症状，不尿尿尿失禁，有一个。描述LUTS治疗的广泛文献，但对预防知之甚少。 “预防较低的尿路症状（加）财团是一个跨学科科学网络建立旨在扩大研究LUT的研究以促进膀胱健康和预防的研究在整个生活过程中的青少年和妇女中的Luts。对于LUTS而言，很少的研究研究了促进膀胱健康的因素。定义了健康的缺乏和厕所行为以及这些行为如何随着时间的推移影响膀胱健康。我们的总体假设是，适应不良和厕所行为有助于较差的膀胱青少年和成年妇女的健康。就像Plus的临床研究中心一样，并与其他人合作设计和结合了纵向队列研究为发展未来预防以促进膀胱健康奠定了基础并预防伯明翰大学（UAB）的阿拉巴马大学。 LUTS临床研究，行为医学，老年医学方面的集体专业知识的研究人员，青少年医学，预防科学，公共卫生，流行病学，生物统计学，健康差异以及医学社会学。 2）LUTS的评估和处理（包括临床检查和生物特异性收集），3）定性方法，4）招募和保留带有或没有LUTS的参与者的不同样本，5）参与。膀胱健康和LUTS的风险/保护因素是未来干预研究的合理目标除了测试国家队列中的许多其他因素，我们建议检查1）使用区域剥夺指数和Andex 2）使用步态速度和生物标记的功能能力与空隙和厕所行为的关联不认识这些因素的作用将支持建立所提出的模型的发展。风险个人和团体以及为教育计划提供信息。试点研究与促进健康的排尿和厕所行为有关。了解使用Amobile应用程序之间在青少年之间跨环境之间的空隙和厕所行为使用地理信息系统映射。促进健康膀胱行为的教育计划。开发有关干预措施的未来研究，以促进整个生活过程中的膀胱健康。