The Cellular and Systems Biology of Sleep and Circadian Rhythms Training Program

睡眠和昼夜节律的细胞和系统生物学培训计划

基本信息

批准号：
10453808
负责人：
Robert W Greene
金额：
$ 14.49万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10453808
关键词：
Cellular biology Circadian Rhythms Sleep Systems Biology Training Programs

项目摘要

Project Summary This is a resubmission of a new competitive proposal for an NHLBI T32 training grant. Sleep/wake and circadian rhythms involve state changes of multisystem biological function that may not in themselves be vital to life but the systems under this modulatory control are vital to life. Further, optimal function of these systems, required for healthy living, is severely compromised in the absence of these intricately organized state changes. The regular and/or rhythmic occurrence of state changes is evolutionarily preserved and adverse outcomes in a variety of organ systems, including CNS, cardiovascular, respiratory, immune, and metabolic systems are associated with their disruption. However, the mechanisms, the mechanisms’ integration and both qualitative and quantitative impact of the state-change related modulation and overall health of the organism (including humans) is not well understood. An overall goal of this T32 proposal is to prepare a group of pre-doctoral and post-doctoral researchers to engage in the challenging endeavor of effective investigation to help remedy this vitally important gap in our biological understanding. Not only will the trainees receive in depth exposure and experience in effective application of multiple and integrated state of the art technologies and experimental approaches from world leaders, but additionally, strong integrative and collaborative interaction and facilitation of this interaction will be generated from our proposed structure within the newly developed Peter O’Donnell Brain Institute. This will enhance the trainee’s ability to engage in independent development of successful research programs that truly span the usual gulf from bench to bedside in a manner that integrates multiple biological systems across behavioral states as demanded by effective sleep/wake and circadian research. Finally, trainees will receive mentored experience in grant writing and in the communication and publication of integrative form of research and career counseling to enabling successful pursuit of a sleep and circadian research oriented career.

项目摘要这是对NHLBI T32培训补助金的新竞争建议的重新提出。睡眠/唤醒和昼夜节律涉及多系统生物学功能的状态变化本身可能对生活至关重要，但这种调节控制下的系统对于生活。此外，这些系统的最佳功能是健康生活所需的，非常严重在没有这些错综复杂的状态变化的情况下，受到妥协。状态变化的规则和/或有节奏的发生在进化上是保留的，对手各种器官系统的结果，包括中枢神经系统，心血管，呼吸道，免疫和代谢系统与它们的破坏有关。但是，机制，机制的整合以及国家改变的定性和定量影响相关的调节和生物体的整体健康（包括人）尚不清楚。该T32提案的总体目标是准备一组博士后和博士后。研究人员参与有效调查的挑战努力，以帮助解决此问题在我们的生物学理解中至关重要的差距。培训不仅会深入在有效应用多重和集成状态的有效应用中的曝光和经验来自世界领导者的技术和实验方法，但此外该互动的集成与协作互动以及设施将从我们在新开发的彼得·奥唐奈脑研究所内提出的结构。这会增强学员参与成功研究的独立发展的能力以整合的方式真正跨越了从长凳到床边的通常跨越通常鸿沟的程序有效的睡眠/唤醒和昼夜研究。最后，学员将获得赠款写作和沟通和综合形式的研究和职业咨询形式启用成功追求睡眠和面向昼夜研究的职业。