Human and Animal Imaging Core

人类和动物成像核心

基本信息

批准号：
10454195
负责人：
WILLIAM Davis GAILLARD
金额：
$ 25.55万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454195
关键词：
Affect Algorithms Anatomy Animal Model Animals Biochemical Bioinformatics Biological Markers Brain Brain Diseases Brain Injuries Brain imaging Cells Child Clinical Clinical Research Cognitive Collaborations Computer software Development Discipline Disease Disease model District of Columbia Dyslexia Education Epilepsy Evaluation Faculty Fostering Functional Imaging Genomics Hospitals Human Human Resources Image Imaging Device Imaging Techniques Imaging technology Inborn Errors of Metabolism Individual Infant Infrastructure Injury Inpatients Institution Intellectual and Developmental Disabilities Research Centers Intervention Investments Laboratories Learning Machine Learning Magnetic Resonance Imaging Measurement Methods Microscopy Mission Molecular Monitor Motion Neonatal Neuronal Plasticity Outcome Pathway Analysis Performance Play Population Positron-Emission Tomography Protocols documentation Quality Control Research Research Personnel Research Project Grants Resources Risk Role Sequence Analysis Services Site Structure Supervision Targeted Research Technical Expertise Techniques Technology Time Tissues Training Training Support Universities Work analytical method animal imaging autism spectrum disorder base career congenital heart disorder cost cost effective data integrity data standards design fetal flexibility human imaging human model hypoxic ischemic injury imaging facilities imaging modality improved in vivo innovation instrument instrumentation magnetic field molecular imaging neonate neural circuit neurobehavioral neuroimaging neuroprotection novel novel imaging technology perinatal stroke pre-clinical preclinical study relating to nervous system response single photon emission computed tomography skills spectroscopic imaging

项目摘要

Abstract The Human and Animal Imaging Core (HAIC) provides access to state-of-the-art in vivo whole brain imaging technologies to DC-IDDRC investigators in order to support, facilitate, and enhance IDD-targeted research in humans and in animal models. To achieve the Core’s aims we have established advanced imaging facilities at three collaborating DC-IDDRC institutions - Howard University (HU), Georgetown University (GU), and Children’s National Hospital (CNH) - that provide structural and functional imaging of animal models and human populations. The HAIC provides access to a wide array of imaging tools to investigate mechanisms of disease, establish biomarkers, examine effects of disease, and monitor outcomes of interventions. We have made significant institutional investments in 3T human MRI scanners at CNH, and GU that provide researchers with state-of-the-art imaging instrumentation and expand our imaging capacity in neonates and ill children. Furthermore, we have also invested in MRI scanner/software upgrades and added PET, SPECT, and CT to the preclinical animal imaging facilities at HU. HAIC personnel provide technical expertise in imaging strategy design, essential imaging services, acquisition and innovative imaging sequences and analysis methods across all sites and institutions. Core faculty and staff also help educate, train, and support investigators in the use of advanced neuroimaging methods, applications, and analysis software as well as foster innovation. The HAIC works synergistically, and fosters collaborations, with other DC-IDDRC cores including the Neurobehavioral Evaluation, the Cell and Tissue Microscopy Core, the Genomics and Bioinformatics Core, and Clinical Translational Cores, and supports the P50 Research Project. Our administrative structure provides the quality control necessary for the integrity of a smoothly functioning core to achieve the DC-IDDRC mission.

抽象的人类和动物成像核心（HAIC）可访问最先进的体内大脑成像 DC-IDDRC研究人员的技术，以支持，促进和增强以IDD为目标的研究人类和动物模型。为了实现核心的目标，我们已经建立了高级成像设施三个合作的DC -IDDRC机构 - 霍华德大学（HU），乔治敦大学（GU）和儿童国家医院（CNH） - 提供动物模型的结构和功能成像，人口。 HAIC提供了多种成像工具的访问，以研究疾病，建立生物标志物，检查疾病的影响以及监测干预措施的结果。我们有在CNH的3T人类MRI扫描仪上进行了大量的机构投资，并为研究人员提供了GU 借助最先进的成像仪器，并扩大了我们在新生儿和生病的孩子中的成像能力。此外，我们还投资了MRI扫描仪/软件升级，并将PET，SPECT和CT添加到 HU的临床前动物成像设施。 HAIC人员提供成像策略的技术专长设计，基本成像服务，获取和创新成像序列和分析方法在所有站点和机构中。核心教职员工还帮助教育，培训和支持调查人员使用高级神经影像学方法，应用程序和分析软件以及促进创新。这海克与其他DC-IDDRC核心（包括神经行为评估，细胞和组织显微镜核心，基因组学和生物信息学核心以及临床翻译核心，并支持P50研究项目。我们的行政结构提供了平滑功能核心以实现DC-IDDRC任务所必需的质量控制。