Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men

成人心脏代谢健康的童年前因：低收入男性的前瞻性研究

• 批准号: 10453445
• 负责人: ANNA L MARSLAND
• 金额: $ 71.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10453445
• 关键词: Address; Adolescence; Adult; Age; Attenuated; Biological Markers; Blood Pressure; Buffers; Cardiometabolic Disease; Cardiovascular Diseases; Cause of Death; Child; Childhood; Chronic Disease; Communities; Development; Diabetes Mellitus; Disadvantaged; Disease; Dyslipidemias; Economic Conditions; Economically Deprived Population; Epidemiology; Family; Growth; Health; Health behavior; Immunologic Factors; Income; Individual; Informal Social Control; Insulin Resistance; Intervention; Investigation; Knowledge; Life; Link; Longitudinal prospective study; Low income; Mediating; Metabolic Pathway; Methods; Mothers; Neighborhoods; Obesity; Outcome; Pathogenesis; Pathway interactions; Phase; Physiologic pulse; Policies; Poverty; Prevention; Prevention program; Process; Prospective Studies; Race; Reporting; Research; Risk; Risk Assessment; Risk Factors; Role; Sampling; Schools; Shapes; Stress; Testing; Toddler; Woman; aged; base; boys; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cardiovascular health; carotid intima-media thickness; community-level factor; disorder risk; early childhood; emerging adult; experience; health disparity; high risk; informant; intergenerational; intervention program; low socioeconomic status; lower income families; men; middle childhood; novel; parent project; physical conditioning; pre-clinical; prevent; programs; prospective; protective factors; recruit; resilience; socioeconomic adversity; socioeconomic disadvantage; socioeconomic disparity; socioeconomics; stem; systemic inflammatory response; teacher; transmission process; young man

Project Summary/Abstract Cardiovascular disease (CVD) and diabetes are leading causes of death among adults in the US, with incident disease following years of accumulating risk conferred through various metabolic pathways (obesity, dyslipidemia, insulin resistance), immune factors (e.g., systemic inflammation), and rising blood pressure. The pathogenesis of CVD and cardiometabolic health begins in childhood, thus it is imperative to identify factors that contribute to emerging cardiometabolic health disparities. Like other chronic diseases, CVD and diabetes track a socioeconomic gradient, with greater lifelong health risk among individuals born into disadvantaged circumstances. However, no prospective studies have carefully characterized links between early socioeconomic disadvantage and adult health, addressing whether poverty during particular developmental stages is especially harmful and delineating developmentally salient risk factors that may link economic disadvantage to cardiometabolic disease (CMD) risk. Guided by the family stress framework, we propose that family-, school- and community-level factors during critical phases of development are pathways through which socioeconomic disadvantage in childhood shapes cardiometabolic health. We also consider the role of child- based protective factors that might buffer the effects of poverty on adult health outcomes. Finally, we explore how race and SES intersect to shape risk for CMD in adulthood and whether adult health behaviors are pathways through which economic disadvantage gives rise to greater propensity for CMD. The project will assess the cardiovascular health of a diverse sample of 248 adult men (aged 31-33 years) who participated in the Pittsburgh Mother & Child Project (PMCP). The parent project recruited a sample of 310 toddlers from low income families and has followed them closely to early adulthood, permitting a comprehensive assessment of risk and protective factors. We will consider whether these factors relate to biomarkers of cardiometabolic health risk and preclinical markers of CVD – carotid intima media thickness and pulse wave velocity. By testing novel contextual pathways at the family, school, and neighborhood levels this investigation will help to identify contexts that can be targeted by programs and policies aimed at reducing socioeconomic disparities in adult health.

项目摘要/摘要 心血管疾病（CVD）和糖尿病是美国成年人的主要死亡原因， 多年通过各种代谢赋予的风险累积多年的事件疾病 途径（肥胖，血脂异常，胰岛素抵抗），免疫因素（例如，全身性 炎症）和血压升高。 CVD和心脏代谢健康的发病机理 从童年开始，因此必须确定有助于新兴的因素 心脏代谢健康差异。像其他慢性疾病一样，CVD和糖尿病跟踪 社会经济梯度，在临床的人中具有更大的终身健康风险 处境不利的情况。但是，没有仔细的前瞻性研究表征 早期社会经济障碍与成人健康之间的联系，解决贫困是否存在 在特定的发展阶段，尤其有害和划定发展 可能将经济灾难与心脏代谢疾病（CMD）风险联系起来的显着风险因素。 在家庭压力框架的指导下，我们建议家庭，学校和社区级别 发展阶段期间的因素是社会经济的途径 儿童时期的缺点是心脏代谢健康。我们还考虑了儿童的作用 - 基于受保护的因素可能会缓冲贫困对成人健康结果的影响。 最后，我们探索种族和SES如何相交以塑造成年后CMD的风险以及是否相交 成人健康行为是经济灾难带来更大的途径 CMD的倾向。该项目将评估248的潜水员样本的心血管健康 参加匹兹堡母子项目的成年男子（31-33岁） （PMCP）。家长项目招募了来自低收入家庭的310个幼儿的样本， 已经紧随其后，直到成年初，允许对风险进行全面评估 和受保护因素。我们将考虑这些因素是否与 CVD的心脏代谢健康风险和临床前标记 - 颈动脉Intima媒体厚度 和脉搏波速度。通过测试家庭，学校和 邻里水平这项投资将有助于确定可以针对的背景 旨在减少成人健康中社会经济差异的计划和政策。