The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.

大脑组织和姿势行为对年轻人背痛症状进展的影响。

• 批准号: 10458714
• 负责人: Jo Armour Smith
• 金额: $ 11.91万
• 依托单位: CHAPMAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458714
• 关键词: Abdominal Muscles; Adult; Area; Ataxia; Back Pain; Behavior; Behavioral Sciences; Brain; California; Caring; Characteristics; Chronic; Chronic low back pain; Clinical; Clinical Research; Clinical Trials; Collaborations; Complex; Data; Data Analyses; Development; Diffuse; Electromyography; Emotions; Environment; Exercise; Fatigue; Fright; Funding; Future; Goals; Health Sciences; Heterogeneity; Incidence; Individual; Industrialization; Intervention; Laboratories; Lead; Locomotion; Longevity; Longitudinal Studies; Low Back Pain; MRI Scans; Magnetic Resonance Imaging; Measures; Mental Depression; Mentors; Mentorship; Morphology; Motion; Motor; Muscle; Muscle Fatigue; Musculoskeletal Equilibrium; Neuraxis; Neuromechanics; Outcome; Pain; Pelvis; Postural adjustments; Posture; Predictive Factor; Predictive Value; Prevalence; Prospective Studies; Psychological Factors; Recording of previous events; Recovery; Recurrence; Rehabilitation therapy; Research; Research Design; Research Training; Rest; Risk; Risk Factors; Sensory; Societies; Spinal; Supination; Symptoms; Testing; Tissues; Training; Universities; Work; acute symptom; base; biopsychosocial; brain behavior; career development; college; cost; density; design; disability; experience; gray matter; middle age; morphometry; motor control; neural correlate; neuroimaging; neuromechanism; pain processing; pain symptom; persistent symptom; predictive modeling; professor; psychologic; relating to nervous system; response; sensorimotor system; young adult

Project Summary/Abstract Candidate. The candidate is an Assistant Professor in Crean College of Health and Behavioral Sciences, at Chapman University. Her research to date has demonstrated altered postural coordination in individuals with low back pain (LBP) and examined neural correlates of anticipatory postural adjustments in the trunk. Her long- term goal is to develop rehabilitation interventions to reduce the development of chronic LBP. This project will help her to understand the influence of neuromechanical and psychological factors on LBP, and will prepare her to design and conduct large longitudinal and clinical trials. Mentorship team and training plan. Primary mentor, Dr. Laura M. Glynn, has extensive experience of conducting prospective studies investigating biopsychosocial influences on brain and behavior. She provides expertise in longitudinal study design and multifactorial analysis, as well as guidance on career development. Dr. Steven C. Cramer is an expert on central nervous system recovery who will advise on magnetic resonance imaging of the sensorimotor system. Dr. Linda Van Dillen has substantial experience in clinical research of individuals with LBP. A mentored practicum at her lab will provide direct experience of management of R01-funded clinical trials. Dr. Jesse V. Jacobs has expertise in neural mechanisms underlying postural coordination. Dr. Rongwen Tain will advise on technical aspects of magnetic resonance imaging and Dr. Babak Shahbaba will provide statistical support. The candidate will also complete didactic training in neuroimaging, multivariate data analysis, and clinical research. Environment. The candidate has substantial opportunities for collaboration and academic development at Chapman, and use of a fully equipped motion capture laboratory. She has access to additional intellectual development opportunities and MRI scanning facilities at University of California, Irvine. Research. The highest incidence of new episodes of LBP occurs during young adulthood. The objective of this study is to identify neuromechanical risk factors for recurrence/progression of LBP in young adults. Aim 1 will use electromyography to determine if changes in trunk/pelvis postural coordination following fatiguing paraspinal exercise are greater in asymptomatic young adults with a history of LBP than those with no history of LBP. Aim 2 will establish if there are alterations in central sensorimotor morphology, connectivity, or activity in young adults with a history of LBP, whether the connectivity and activation differences between groups are more evident following fatiguing exercise, and whether this brain reorganization is associated with altered postural coordination. Aim 3 will identify if neuromechanical factors are independently associated with recurrence/progression of LBP symptoms over 18 months.

项目摘要/摘要 候选人。该候选人是克雷恩健康与行为科学学院的助理教授， 查普曼大学。迄今为止，她的研究表明，患有 腰痛（LBP）检查并检查了躯干中预期姿势调整的神经相关性。她的长期 术语目标是制定康复干预措施，以减少慢性LBP的发展。这个项目将 帮助她了解神经力学和心理因素对LBP的影响，并将准备 她设计和进行大型纵向和临床试验。指导团队和培训计划。基本的 导师Laura M. Glynn博士在进行前瞻性研究方面拥有丰富的经验 生物心理社会对大脑和行为的影响。她在纵向研究设计方面提供专业知识 多因素分析以及职业发展指导。 Steven C. Cramer博士是专家 中枢神经系统恢复将为感觉运动系统的磁共振成像提供建议。 Linda van Dillen博士在LBP患者的临床研究中具有丰富的经验。一个导师 她的实验室实习将提供R01资助的临床试验管理的直接经验。杰西·V博士 雅各布斯在姿势协调的基础神经机制方面具有专业知识。 Rongwen Tain博士将建议 磁共振成像和Babak Shahbaba博士的技术方面将提供统计支持。这 候选人还将完成神经影像，多元数据分析和临床研究的教学培训。 环境。候选人在合作和学术发展上有很大的机会 查普曼，并使用设备齐全的运动捕获实验室。她有其他知识分子 加利福尼亚大学尔湾分校的开发机会和MRI扫描设施。研究。这 LBP新发作的最高发病率是在成年期间发生的。这项研究的目的是 确定年轻人LBP复发/进展的神经力学风险因素。 AIM 1将使用 肌电图以确定疲劳性脊柱后的躯干/骨盆姿势协调的变化 LBP史的无症状年轻人比没有LBP史的年轻人更大。目的 2将确定中央感觉运动形态，连通性或活性是否发生变化 具有LBP病史的成年人，组之间的连通性和激活差异是否更多 疲劳运动后明显明显，以及这种大脑重组是否与姿势改变有关 协调。 AIM 3将确定神经力学因素是否与 LBP症状在18个月内复发/进展。

项目成果

Fear Avoidance Predicts Persistent Pain in Young Adults With Low Back Pain: A Prospective Study.

• DOI: 10.2519/jospt.2021.9828
• 发表时间: 2021-08
• 期刊: The Journal of orthopaedic and sports physical therapy
• 作者: Smith JA;Russo L;Santayana N
• 通讯作者: Santayana N

Identifying the neural correlates of anticipatory postural control: A novel fMRI paradigm.

• DOI: 10.1002/hbm.26332
• 发表时间: 2023-07
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Smith, Jo Armour;Tain, Rongwen;Sharp, Kelli G.;Glynn, Laura M.;Van Dillen, Linda R.;Henslee, Korinne;Jacobs, Jesse V.;Cramer, Steven C.
• 通讯作者: Cramer, Steven C.

Task-invariance and reliability of anticipatory postural adjustments in healthy young adults.

健康年轻人预期姿势调整的任务不变性和可靠性。

• DOI: 10.1016/j.gaitpost.2020.01.003
• 发表时间: 2020
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Smith,JoArmour;Ignasiak,NiklasKönig;Jacobs,JesseV
• 通讯作者: Jacobs,JesseV

The Effect of Spinal Muscle Fatigue and Psychosocial Factors on Pressure-Pain Threshold in Healthy Adults.

• DOI: 10.1155/2023/7336477
• 发表时间: 2023
• 期刊: PAIN RESEARCH & MANAGEMENT
• 影响因子: 2.9
• 作者: Mais, Susan;Smith, Jo Armour
• 通讯作者: Smith, Jo Armour

Adaptations in trunk-pelvis coordination variability in response to fatiguing exercise.

• DOI: 10.1016/j.gaitpost.2020.11.019
• 发表时间: 2021-03
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Smith JA;Eiteman-Pang WK;Soangra R;König Ignasiak N
• 通讯作者: König Ignasiak N