Cognition and neuropathology in World Trade Center-exposed FDNY, NYPD, and construction worker responders

暴露于世贸中心的纽约消防局、纽约警察局和建筑工人急救人员的认知和神经病理学

• 批准号: 10459186
• 负责人: SEAN CLOUSTON
• 金额: $ 58.97万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459186
• 关键词: Cognition; neuropathology; World; Trade; Center

Abstract World Trade Center (WTC) responders were exposed to a mix of tiny dust particles as they participated in rescue and recovery efforts at the WTC in the aftermath of 9/11/2001. A significant number continue to suffer from Post- Traumatic Stress Disorder (PTSD) as a result of their experiences. These may have changed their expectations of brain health as they age. Our team has interrogated the potential for early signs of cognitive aging and has identified higher than expected burden of mild cognitive impairment (MCI) and, surprisingly, changes to physical functional limitations (PFL) common in both physical disability and in neurodegenerative disease. We propose that MCI is arising early because PTSD and inhaled particulate exposures have caused a neurodegenerative disease, resulting in increased Alzheimer’s disease neuropathology. We propose to conduct a large study of WTC-exposed Fire Department of the City of New York (FDNY) responders that includes cognitive functioning profiling alongside state-of-the-art proteomic studies of blood-based biomarkers alongside a PET/MRI study of 30 medically healthy WTC responders using two well-validated positron emission tomography (PET) ligands ([11C]-PiB to measure β-amyloid, and [18F]-Flortaucipir to measure tauopathy). Detailed cognitive testing will help to determine the level of cognitive dysfunction. Simultaneous structural MRI will be used to measure the extent of neurodegeneration. This study is timely because we are in a critical period when neuropathology is emerging and the etiology of the disease is still possible to determine.

抽象的 世界贸易中心（WTC）响应者暴露于 在2001年9月11日的后期，WTC的恢复产物。 创伤性应激障碍（PTSD）由于他们的经验可能改变了他们的期望 随着年龄的增长，大脑健康。 确定的轻度认知障碍负担高于预期的负担（MCI），令人惊讶地改变了身体 我们提出的身体和神经退行性疾病中的功能局限性（PFL） 由于PTSD和吸入的特定暴露引起了神经退行性，因此MCI正在提早出现 疾病，导致阿尔茨海默氏病神经病理学增加。 纽约市（FDNY）的暴露消防局（FDNY）的反应包括认知功能 与血液基生物标志物的最先进研究以及对宠物/MRI研究以及对 30个对医学健康的WTC响应者，使用两个验证的正电子发射Tomigraphy（PET）配体 （[11c] -pib到MISUREβ-淀粉样蛋白和[18F] -Flortaucipir to Misure tauopathy）。 确定认知功能障碍的水平。 神经变性是在元素之前的时间 仍有可能确定疾病的新兴和病因。