Core D: University of Kentucky Alzheimer's Disease Core Center

核心 D：肯塔基大学阿尔茨海默病核心中心

基本信息

批准号：
10459469
负责人：
PETER T. NELSON
金额：
$ 28.01万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10459469
关键词：
Address Aging Alzheimer&apos s Disease Alzheimer&apos s Disease Core Center Area Autopsy Biological Biological Markers Biological Specimen Banks Biometry Brain Brain Diseases Brain imaging Brain region Caring Catalogs Cerebrospinal Fluid Cerebrovascular Disorders Cerebrum Clinical Clinical Trials Cognitive Collaborations Complement Consensus Correlation Studies Correlative Study DNA Data Databases Dementia Dementia with Lewy Bodies Deposition Diagnosis Diagnostic Disease Down Syndrome Elderly Ensure Etiology Evaluation Freezing Frontotemporal Lobar Degenerations Genetic study Genomics Goals Impaired cognition Individual Infrastructure Institutes Investigation Kentucky Laboratory Research Lesion Medical Genetics Memory Methodology Methods Mission Nerve Degeneration Neurofibrillary Tangles Oxidative Stress Pathologic Pathology Patients Plasma Preventive measure Process Protocols documentation Publishing Research Research Personnel Research Support Resources Running Sampling Senile Plaques Serum Services Specimen Staging Standardization Syndrome System Tauopathies Therapeutic Thinness Time Tissue Banks Tissue Sample Tissues Universities Work age related age related neurodegeneration aging brain alpha synuclein blood product brain tissue cerebrovascular pathology clinical biomarkers cohort data management digital digital pathology early satiety experience genome wide association study hippocampal sclerosis innovation limbic-predominant age-related TDP-43 encephalopathy meetings mixed dementia neuroinflammation neuropathology novel pre-clinical protein TDP-43 religious order study statistics symposium synucleinopathy tau Proteins tool

项目摘要

Project Summary/Abstract: Neuropathology Core The overall objective of the Neuropathology Core of the UK-ADRC is to support research on normal brain aging, presymptomatic AD, MCI, early and late AD, mixed dementia syndromes, and other dementing disorders. Autopsies will be performed by our Rapid Autopsy Team on longitudinally followed subjects from our Clinical Core. We will perform short post-mortem interval autopsies, and we will maintain a high autopsy rate. This Core is optimally tailored to help address important research questions. The Core will provide brain tissue, CSF and other biospecimens for investigators at UK, other ADRCs, and outside investigators. The Core will also provide consensus conference determined diagnoses, quantitation of neurofibrillary tangles, neuritic plaques, and diffuse plaques from 8 brain regions, Ab quantitation, Braak staging, CERAD, and NIA-Reagan Institute staging on all autopsied cases, along with evaluation of alpha-synuclein and TDP-43 proteinopathy. This brain bank has been operating continuously for over three decades with a strong track record, so special care will be taken to ensure diagnostic excellence, consistency, and continuity. The Core will maintain a tissue bank of the above specimens and frozen serum, plasma, buffy coats and CSF from living patients. Special emphasis will be placed on generating rigorous quantititative pathologic metrics from digital pathology, and providing investigators with specimens from cognitively intact control subjects with no Ab deposition and sparse tau pathology (successful cerebral aging) and many cases with mixed pathologies. Providing these samples will contribute to clinical-pathological correlation studies and cutting-edge research that include sponsored studies related to AD genomics, oxidative stress, hippocampal sclerosis/LATE, dementia with Lewy bodies, Down syndrome, and neuroinflammation. Frequent consensus conferences will be held with the Clinical, Biomarker, and Data Management and Statistics Cores to help define clinical-pathological diagnoses on all autopsied subjects. The Neuropathology Core is strongly integrated with other Cores of the UK-ADRC, and exploits unique opportunities to conduct clinical-pathological correlative studies on longitudinally followed subjects. Through these methods we will better understand normal brain aging and the transition to multi- etiology dementia with the goal of contributing to therapeutic or preventive measures. The Neuropathology Core complements the other Cores of the UK-ADRC to provide extremely essential diagnoses and tissue samples that are required for many cutting-edge researchers at the University of Kentucky and elsewhere. We will build on our track record of excellence using innovative tools related to brain autopsies, neuropathological diagnoses, tissue banking, and clinical-pathological correlation. Our specific aims are: Aim 1: Provide state-of-the-art neuropathological and biospecimen repository services Aim 2: Leverage neuropathology resources and expertise to contribute to research efforts Aim 3: Integrate with other cores to contribute to administrative, research and educational missions

项目摘要/摘要：神经病理学核心英国-ADRC神经病理学核心的总体目标是支持对正常大脑的研究衰老，症状性AD，MCI，早期和晚期AD，混合痴呆综合征和其他痴呆症疾病。我们的快速尸检团队将在纵向上进行尸检团队进行尸检。临床核心。我们将执行简短的验尸间隔尸检，并保持高尸检率。该核心是最佳量身定制的，以帮助解决重要的研究问题。核心将提供脑组织， CSF和其他针对英国调查人员，其他ADRC和外部调查人员的生物测量。核心意愿还提供共识会议确定的诊断，神经纤维缠结的定量来自8个大脑区域，AB定量，Braak分期，Cerad和Nia-Reagan的斑块和弥漫斑块研究所分期在所有尸体式病例上，并评估α-突触核蛋白和TDP-43蛋白质病。这家大脑银行一直在连续运营超过三十年，并具有良好的往绩，所以很特别要注意确保卓越诊断，一致性和连续性。核心将保持组织来自活着的患者的上述标本和冷冻血清，血浆，Buffy Coats和CSF。特别的将重点放在从数字病理学中产生严格的定量病理指标，并向调查人员提供来自没有AB沉积的认知完整控制受试者的标本稀疏的tau病理学（成功的脑衰老）和许多混合病理。提供这些样本将有助于临床病理相关研究和尖端研究，包括赞助的与AD基因组学，氧化应激，海马硬化/晚期，痴呆症有关的研究身体，唐氏综合症和神经炎症。频繁的共识会议将与临床，生物标志物以及数据管理和统计核心，以帮助定义临床病理诊断在所有动体主题上。神经病理学核心与英国 - 阿德里奇的其他核心强烈融合，并利用了对纵向进行临床病理相关研究的独特机会主题。通过这些方法，我们将更好地理解正常的大脑衰老以及向多的过渡病因痴呆症的目的是为治疗或预防措施做出贡献。神经病理学核心补充了英国-ADRC的其他核心，以提供极为必要的诊断和组织肯塔基大学和其他地方的许多尖端研究人员所需的样本。我们将使用与脑尸体尸体尸体术有关的创新工具以我们的卓越成绩建立在我们的卓越成绩的基础上诊断，组织库和临床病理相关性。我们的具体目的是：目标1：提供最先进的神经病理学和生物循环库库服务目标2：利用神经病理学资源和专业知识来为研究努力做出贡献目标3：与其他核心集成以促进行政，研究和教育任务