Research training in respiratory biology

呼吸生物学研究培训

• 批准号: 10445225
• 负责人: Gokhan M. Mutlu
• 金额: $ 47.6万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445225
• 关键词: Biology; Research Training; respiratory

PROJECT SUMMARY The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdiscipli- nary Program stems from the highly collaborative nature of our 38 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation that focus on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis, cardiopulmonary arrest, and sleep disturbance. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Anne I. Sperling, PhD and Julian Solway, MD, with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide oversight and continuity of review, and an Admissions/Steering Committee reviews trainee progress. We request funding for 10 post-doctoral trainees. PhD, MD, and MD/PhD trainees are enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will devote not more than 10% time to clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.

项目概要 我们为芝加哥大学研究培训计划竞争续展申请的目标 呼吸生物学旨在培养年轻科学家从事研究职业，解决机制和问题 治疗人类疾病，重点是呼吸道病理学。这种跨学科的凝聚力 nary 项目源于我们 7 个系 38 名资金雄厚的教员的高度协作性质，以及 芝加哥大学分子工程研究所专注于多个领域。哮喘研究 气道生理学/免疫学继续关注气道炎症、气道平滑肌和 上皮结构和功能、B 细胞和 T 细胞激活、哮喘遗传学和临床研究。这些 补充肺免疫学和移植研究项目，重点关注细胞和分子 移植免疫学的机制及其对患者的转化应用，以及 间质性肺疾病的转化研究利用了世界上最大的专门诊所之一 中西部。气道和粘膜微生物组的集中增加了这一至关重要的新兴研究 哮喘和间质性肺病 (ILD) 计划的指导。危重疾病和急性肺损伤的研究继续解决 氧感应和消耗的亚细胞决定因素、细胞对缺氧的反应、膜 生物学、内皮和上皮屏障功能以及脓毒症患者的床边翻译， 心肺骤停和睡眠障碍。对这些的补充是遗传学的跨领域研究 以及表观遗传学和健康研究与伦理学专业。项目主管是 Anne I. Sperling， 博士和医学博士朱利安·索尔韦 (Julian Solway) 以及副主任史蒂文·怀特 (Steven White) 医学博士（指导和职业发展）。 Christopher Olopade，医学博士、公共卫生硕士，担任多元化委员会主席。内部和外部顾问提供监督 和审查的连续性，招生/指导委员会审查学员的进度。我们请求资金 招收博士后10名。博士、医学博士和医学博士/博士生一起注册和培训。合作 基础和临床科学家的研究进一步增强了我们的综合性和转化性 程序。所有研究员从事至少 2 年的全职研究，医学博士研究员投入的时间不超过 在本计划的支持下，有 10% 的时间进行临床培训。培训由 5 个主要部分组成： 在教师共同导师的直接监督下进行的研究项目；稳健的核心课程 研讨会系列和课程以及额外的定制正式课程；核心能力包括 科学交流、资助写作和指导；多学科研究；和个性化职业 发展规划。该计划的先前学员已经开展了成功的独立研究 职业占很大比例。这里提出的改进应该会进一步提高成功的可能性 未来的实习生。