ELSA-HCAP 2: Second Administration of the Harmonised Cognitive Assessment Protocol (HCAP) in the English Longitudinal Study of Ageing

ELSA-HCAP 2：英国老龄化纵向研究中第二次实施统一认知评估协议 (HCAP)

• 批准号: 10445098
• 负责人: Andrew Steptoe
• 金额: $ 114.08万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10445098
• 关键词: African ancestry; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian ancestry; Behavioral; Biological; COVID-19 impact; COVID-19 risk; Caribbean region; Caring; Cessation of life; Clinical; Cognition; Cognitive; Cognitive aging; Country; Data; Data Set; Dementia; Deposition; Development; Economic Burden; Economics; Elderly; Emotional; England; Environmental Risk Factor; Epidemiology; Family; Follow-Up Studies; Funding; Future; Genetic; Grant; Great Britain; Health; Health and Retirement Study; Health system; Hospitals; Impaired cognition; Incidence; Incidence Study; Individual; Interview; Language; Link; Longitudinal Studies; Measurement; Measures; Modeling; Northern Ireland; Older Population; Outcome; Participant; Persons; Policies; Prevalence; Protocols documentation; Psychology; Publishing; Quality of life; Research Personnel; Respondent; Retirement; Risk; Risk Factors; SARS-CoV-2 infection; Sampling; Services; Social Impacts; Societies; Sociology; Taxes; Time; Universities; Variant; Walking; Woman; aged; care systems; cognitive function; cognitive performance; cognitive testing; cohort; economic impact; ethnic disparity; ethnic minority; ethnic minority population; human old age (65+); informant; insight; member; men; mild cognitive impairment; multidisciplinary; multiple chronic conditions; pandemic disease; physical conditioning; population based; prediction algorithm; racial and ethnic disparities; racial minority; response; social; social factors; socioeconomic disparity; socioeconomics; statistics; virtual; welfare

Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) impose a devastating burden on society and the quality of life of sufferers and their families, and present serious challenges to health and social care. Cross-national comparisons of older populations supply valuable information about the prevalence of mild cognitive impairment and AD/ADRD in different countries, and can provide insights into the impact of different risk factors, welfare regimes, and health and social care policies. In 2018, the Harmonized Cognitive Assessment Protocol (HCAP) was completed by 1,273 participants in the English Longitudinal Study of Ageing (ELSA) aged ≥65, selected on the basis of previous cognitive performance to include individuals with low, moderate and normal cognition. Informants were also assessed. The HCAP was identical to that administered in the Health and Retirement Study (HRS) in 2016, and the common language has allowed direct comparisons between the USA and England. This proposed follow-up study will administer the HCAP in 2023 to an expanded sample that will include all surviving participants in the original study (~1,000), plus a new sample including all ethnic minority participant in ELSA aged ≥65 years and randomly selected additional cohort members to bring the achieved sample to 2,000. We expect the protocol to be very similar to that used in the original study, including face-to- face assessments with participants and interviews with informants about changes in the person’s cognitive status. The readministration of the protocol to the original sample will permit assessment of trajectories of cognitive impairment and the incidence of AD/ADRD over a 5 year period, and facilitate comparisons with the changes over time observed in the HRS. The inclusion of the ethnic minority sample will add to the limited evidence of ethnic disparities in older age cognitive function in England. Analyses will focus on socioeconomic disparities in cognitive decline, and the progression of cognitive impairment to dementia. Extrapolation to the full ELSA cohort will facilitate modeling of social and economic impacts of AD/ADRD, and will provide a basis for analyses of the multifactorial determinants of cognitive decline over the 20+ years since the study started. The study will provide detailed information on the relationship between cognition and COVID-19 risk, and on socioeconomic and ethnic disparities in the impact of the pandemic on cognition. We will prepare a well- documented anonymized dataset for deposit with the UK Data Service that will be accessible to researchers and scholars throughout the world for further analysis. This application is being submitted by Andrew Steptoe (PI) and Paola Zaninotto (Co-I) from UCL and Carol Brayne (Co-I) from the University of Cambridge, with consultants from the HRS (David Weir, Kenneth Langa), the Gateway to Global Aging (Jinkook Lee) and the Cognitive Function and Ageing Study (Fiona Matthews).

阿尔茨海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD）施加毁灭性的伯宁 社会以及患者及其家人的生活质量，并对健康和社会提出了严重的挑战 关心。老年人口的跨国比较提供有关中期流行的有价值信息 不同国家的认知障碍和AD/ADRD，可以提供有关不同国家的影响 风险因素，福利制度以及健康和社会护理政策。在2018年，协调的认知评估 协议（HCAP）由1,273名参与者完成英语衰老纵向研究（ELSA）老化的参与者 ≥65，根据先前的认知表现选择，包括低，中和中等的个体 正常认知。也对线人进行了评估。 HCAP与健康管理的HCAP相同 和2016年的退休研究（HRS），通用语言允许直接比较 美国和英国。这项拟议的后续研究将在2023年管理HCAP，以扩大样本 将包括所有尚存的参与者（〜1,000），以及包括所有少数民族在内的新样本 参加≥65岁的Elsa的参与者，随机选择了其他队列成员以带来所能达到的成员 样本至2,000。我们希望该协议与原始研究中使用的方案非常相似，包括面对面 与参与者的面对评估以及有关该人认知变化的信息的访谈 地位。对原始样本的协议的重新管理将允许评估 认知障碍和AD/ADRD在5年内的事件，并促进与 随着时间的流逝，在HRS中观察到的变化。包括少数民族样本的包括 英格兰老年认知功能中种族差异的证据。分析将重点放在社会经济上 认知能力下降的差异以及认知障碍对痴呆症的发展。外推到 Elsa队列将促进建模AD/ADRD的社会和经济影响，并将为 自研究开始的20多年以上认知下降的多因素决定者的分析。这 研究将提供有关认知与Covid-19风险之间关系的详细信息，以及 大流行对认知影响的社会经济和种族差异。我们将准备一个很好的 记录了匿名数据集，以存入英国数据服务，研究人员可以访问 全世界的学者进行进一步分析。此申请由Andrew Steptoe（PI）提交 来自剑桥大学的UCL和Carol Brayne（Co-I）的Paola Zaninotto（Co-I）与顾问一起 从HRS（David Weir，Kenneth Langa），通往全球衰老的门户（Jinkook Lee）和认知 功能和老化研究（Fiona Matthews）。