ELSA-HCAP 2: Second Administration of the Harmonised Cognitive Assessment Protocol (HCAP) in the English Longitudinal Study of Ageing

ELSA-HCAP 2：英国老龄化纵向研究中第二次实施统一认知评估协议 (HCAP)

• 批准号: 10445098
• 负责人: Andrew Steptoe
• 金额: $ 114.08万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10445098
• 关键词: African ancestry; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian ancestry; Behavioral; Biological; COVID-19 impact; COVID-19 risk; Caribbean region; Caring; Cessation of life; Clinical; Cognition; Cognitive; Cognitive aging; Country; Data; Data Set; Dementia; Deposition; Development; Economic Burden; Economics; Elderly; Emotional; England; Environmental Risk Factor; Epidemiology; Family; Follow-Up Studies; Funding; Future; Genetic; Grant; Great Britain; Health; Health and Retirement Study; Health system; Hospitals; Impaired cognition; Incidence; Incidence Study; Individual; Interview; Language; Link; Longitudinal Studies; Measurement; Measures; Modeling; Northern Ireland; Older Population; Outcome; Participant; Persons; Policies; Prevalence; Protocols documentation; Psychology; Publishing; Quality of life; Research Personnel; Respondent; Retirement; Risk; Risk Factors; SARS-CoV-2 infection; Sampling; Services; Social Impacts; Societies; Sociology; Taxes; Time; Universities; Variant; Walking; Woman; aged; care systems; cognitive function; cognitive performance; cognitive testing; cohort; economic impact; ethnic disparity; ethnic minority; ethnic minority population; human old age (65+); informant; insight; member; men; mild cognitive impairment; multidisciplinary; multiple chronic conditions; pandemic disease; physical conditioning; population based; prediction algorithm; racial and ethnic disparities; racial minority; response; social; social factors; socioeconomic disparity; socioeconomics; statistics; virtual; welfare

Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) impose a devastating burden on society and the quality of life of sufferers and their families, and present serious challenges to health and social care. Cross-national comparisons of older populations supply valuable information about the prevalence of mild cognitive impairment and AD/ADRD in different countries, and can provide insights into the impact of different risk factors, welfare regimes, and health and social care policies. In 2018, the Harmonized Cognitive Assessment Protocol (HCAP) was completed by 1,273 participants in the English Longitudinal Study of Ageing (ELSA) aged ≥65, selected on the basis of previous cognitive performance to include individuals with low, moderate and normal cognition. Informants were also assessed. The HCAP was identical to that administered in the Health and Retirement Study (HRS) in 2016, and the common language has allowed direct comparisons between the USA and England. This proposed follow-up study will administer the HCAP in 2023 to an expanded sample that will include all surviving participants in the original study (~1,000), plus a new sample including all ethnic minority participant in ELSA aged ≥65 years and randomly selected additional cohort members to bring the achieved sample to 2,000. We expect the protocol to be very similar to that used in the original study, including face-to- face assessments with participants and interviews with informants about changes in the person’s cognitive status. The readministration of the protocol to the original sample will permit assessment of trajectories of cognitive impairment and the incidence of AD/ADRD over a 5 year period, and facilitate comparisons with the changes over time observed in the HRS. The inclusion of the ethnic minority sample will add to the limited evidence of ethnic disparities in older age cognitive function in England. Analyses will focus on socioeconomic disparities in cognitive decline, and the progression of cognitive impairment to dementia. Extrapolation to the full ELSA cohort will facilitate modeling of social and economic impacts of AD/ADRD, and will provide a basis for analyses of the multifactorial determinants of cognitive decline over the 20+ years since the study started. The study will provide detailed information on the relationship between cognition and COVID-19 risk, and on socioeconomic and ethnic disparities in the impact of the pandemic on cognition. We will prepare a well- documented anonymized dataset for deposit with the UK Data Service that will be accessible to researchers and scholars throughout the world for further analysis. This application is being submitted by Andrew Steptoe (PI) and Paola Zaninotto (Co-I) from UCL and Carol Brayne (Co-I) from the University of Cambridge, with consultants from the HRS (David Weir, Kenneth Langa), the Gateway to Global Aging (Jinkook Lee) and the Cognitive Function and Ageing Study (Fiona Matthews).

阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）给人们带来了毁灭性的负担 社会和患者及其家人的生活质量，并对健康和社会构成严重挑战 老年人口的跨国比较提供了有关轻度患病率的宝贵信息。 不同国家的认知障碍和AD/ADRD，可以深入了解不同国家的影响 风险因素、福利制度以及健康和社会保健政策 2018 年，统一认知评估。 方案 (HCAP) 由英国老龄化纵向研究 (ELSA) 的 1,273 名参与者完成 ≥65，根据以前的认知表现进行选择，包括低、中和 还评估了受访者的正常认知能力。 和 2016 年退休研究（HRS），共同语言允许直接比较 美国和英国。这项拟议的后续研究将在 2023 年对扩大的样本进行 HCAP 将包括原始研究中所有幸存的参与者（约 1,000 名），以及包括所有少数民族的新样本 年龄≥65 岁的 ELSA 参与者和随机选择的其他队列成员带来所取得的成就 我们预计该方案与原始研究中使用的方案非常相似，包括面对面的研究。 面对参与者的评估以及对知情人的采访，了解个人认知的变化 对原始样本重新执行方案将允许评估轨迹。 5 年期间的认知障碍和 AD/ADRD 发生率，并便于与 HRS 中观察到的随着时间的推移而发生的变化 少数民族样本的纳入将增加有限的范围。 英国老年认知功能种族差异的证据分析将集中于社会经济。 认知能力下降的差异，以及认知障碍到痴呆的进展。 ELSA 队列将促进 AD/ADRD 的社会和经济影响建模，并将为以下方面提供基础： 自研究开始以来 20 多年来，对认知能力下降的多因素决定因素进行了分析。 研究将提供有关认知与 COVID-19 风险之间关系的详细信息，以及 失业和种族差异对认知的影响我们将做好准备。 记录的匿名数据集将存放在英国数据服务中心，研究人员和 世界各地的学者进行进一步分析 该申请由 Andrew Steptoe (PI) 提交。 和来自伦敦大学学院 (UCL) 的 Paola Zaninotto (Co-I) 和来自剑桥大学的 Carol Brayne (Co-I) 以及顾问 来自 HRS（David Weir、Kenneth Langa）、全球老龄化之门（Jinkook Lee）和认知 功能和衰老研究（菲奥娜·马修斯）。