The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer

德克萨斯州-路易斯安那州慢性胰腺炎、糖尿病和胰腺癌研究联盟

• 批准号: 10445065
• 负责人: SURESH T. CHARI
• 金额: $ 26.32万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-05 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445065
• 关键词: Accident and Emergency department; African American population; Algorithms; Ancillary Study; Biological; Cancer Center; Clinic; Clinical; Clinical Data; Clinical Research; Clinics and Hospitals; Cohort Studies; Collaborations; Communities; Computerized Medical Record; Consent; Diabetes Mellitus; Diagnosis; Diagnostic; Endocrinologist; Epidemiology; Evaluation; Exocrine pancreatic insufficiency; Familiarity; Felis catus; Functional disorder; Gastroenterologist; Gastroenterology; Goals; Health Sciences; Health system; Healthcare; Healthcare Systems; Hospitals; Hyperglycemia; Incidence; Information Technology; Infrastructure; Inpatients; Institution; Internist; Link; Location; Longitudinal cohort study; Louisiana; Malignant neoplasm of pancreas; Minority Groups; National Institute of Diabetes and Digestive and Kidney Diseases; Outpatients; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patient Care; Patient Recruitments; Patients; Performance; Play; Population; Population Heterogeneity; Positioning Attribute; Primary Care Physician; Primary Health Care; Principal Investigator; Procedures; Prospective Studies; Prospective cohort; Race; Records; Research Personnel; Research Subjects; Resources; Retrospective Studies; Role; Running; Secondary to; Seminal; Series; Site; System; Testing; Texas; Therapeutic; Underrepresented Minority; Universities; base; chronic pain; chronic pancreatitis; cohort; data management; data warehouse; design; epidemiology study; ethnic diversity; experience; falls; innovation; insight; inter-institutional; novel; patient population; prospective; recruit; research study; success; tertiary care; translational study; working group

PROJECT SUMMARY/ABSTRACT Our proposal is in keeping with the objectives of the RFA to continue the excellent ongoing studies of the consortium (CPDPC) to study the relationship between Chronic Pancreatitis (CP), Diabetes (DM) and Pancreatic Cancer (PDAC). The Principal Investigators of this proposal (Drs. Chari and Maitra, both currently based at UT MD Anderson Cancer Center, UTMDACC) have played key and substantial roles in the first cycle of the CPDPC. First, they have served as co-leaders of the DM-PDAC working group, which has been responsible for the design and conduct of the ongoing NOD study, which was inspired by a series of seminal observations made by Dr. Chari in the 2000s. Second, Dr. Maitra has served as Co-PI of the Data Management and Coordination Center (DMCC) of the CPDPC, which provides him with extensive familiarity with the inner workings of data management and oversight required for accrual to NOD and other prospective cohorts. Third, Dr. Chari was previously the site Co-PI of Mayo Clinic site, which has contributed to all aspects of CPDPC in the last cycle. From the experience of the past 4.5 years, it is clear that successful recruitment of subjects to these studies requires a mix of tertiary care hospitals (for PROCEED and DETECT cohorts), combined with access to large primary care healthcare systems with integrated electronic medical record systems, information technology (IT) support and infrastructure (for the NOD study). To this end, an Alliance of Texas and Louisiana investigators and institutions overseen by the PIs at UTMDACC will recruit to ongoing CPDPC cohort studies. In addition, we propose 6 ancillary studies that are ideally suited for performance by a collaborative consortium and significantly advance our understanding of the interconnected pathologies of CP, PDAC and DM. In accordance with the RFA, the Specific Aims of our proposal are to: Aim 1 a) Recruit subjects for PROCEED study: This will occur at the University of Texas Health Sciences Center, Houston (UTHSC-H) and Memorial Hermann Health System, both large volume gastroenterology practices that are well positioned to recruit patients for the PROCEED Study. b) Recruit subjects for the DETECT study: The UTHSC-H will recruit patients for DETECT study c) Recruit subjects for the NOD Study: The recruitment will occur through the Ochsner Clinic, Louisiana, a large, integrated primary health system in Louisiana, which is also highly enriched for underrepresented minority population of African Americans, who are known to harbor a preponderance of both DM and PDAC. Aim 2) Perform a series of innovative ancillary studies to examine the association among CP, DM and PDAC: 6 such studies are outlined in this proposal.

项目摘要/摘要 我们的建议与RFA的目标保持一致，以继续对 联盟（CPDPC）研究慢性胰腺炎（CP），糖尿病（DM）和胰腺 癌症（PDAC）。该提案的主要调查员（Chari和Maitra博士，目前都位于UT MD Anderson Cancer Center，UTMDACC）在CPDPC的第一个周期中扮演着重要的角色。 首先，他们曾担任DM-PDAC工作组的共同领导者，该组负责设计 并进行了正在进行的点头研究，该研究的灵感来自博士博士的一系列开创性观察结果。 2000年代的chari。其次，Maitra博士曾担任数据管理与协调中心的共同点 CPDPC的（DMCC），这使他对数据的内部工作非常熟悉 对点头和其他前瞻性队列所需的管理和监督。第三，Chari博士是 以前是Mayo Clinic网站的站点Co-Pi，在最后一个周期中为CPDPC的各个方面做出了贡献。 从过去4。5年的经验开始，很明显，成功招募这些研究的对象 需要大三级护理医院（用于进行和检测的同类），并结合使用大型医院 带有集成电子病历系统的初级保健医疗系统，信息技术（IT） 支持和基础设施（用于点头研究）。为此，得克萨斯州和路易斯安那州的调查员联盟以及 由UTMDACC PIS监督的机构将招募正在进行的CPDPC队列研究。另外，我们 提出了6项辅助研究，非常适合由协作财团进行表现 促进我们对CP，PDAC和DM相互联系的病理的理解。按照 RFA，我们提案的具体目的是：目标1 a）招聘对象进行研究：这将发生在 德克萨斯大学卫生科学中心，休斯敦（UTHSC-H）和纪念赫尔曼卫生系统， 两种大量的胃肠病学实践都可以很好地招募患者进行研究。 b）招募检测研究的受试者：UTHSC-H将招募患者进行检测研究c）招募 NOD研究的受试者：招聘将通过路易斯安那州的Ochsner诊所进行，这是一个大型综合的 路易斯安那州的主要卫生系统，该系统也非常丰富 非洲裔美国人，众所周知，他们都有大量的DM和PDAC。目标2）执行系列 创新的辅助研究以检查CP，DM和PDAC之间的关联：6个这样的研究概述了 在此提案中。