A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve Injuries

基于水凝胶离子电路的电刺激系统，用于周围神经损伤后失神经肌肉的恢复

• 批准号: 10445353
• 负责人: Bin Duan
• 金额: $ 19.98万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-06 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10445353
• 关键词: Action Potentials; Adverse effects; Animals; Chemical-Induced Change; Clinic; Clinical Trials; Coupled; Development; Device Designs; Devices; Electric Stimulation; Electrodes; Electrons; Exercise; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Generations; Goals; Human; Hydrogels; In Vitro; Ions; Lead; Mission; Modality; Modeling; Motor; Motor Neurons; Muscle; Muscle function; Muscle rehabilitation; Muscular Atrophy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; Outcome; Patients; Peripheral nerve injury; Protocols documentation; Public Health; Quality of life; Rattus; Reaction; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Research; Safety; Sensory; Signal Transduction; System; Technology; Temperature; Testing; Therapeutic; Tissues; Treatment Efficacy; base; effective therapy; efficacy evaluation; improved; in vivo; motor recovery; muscular structure; muscular system; novel; pre-clinical; preservation; prevent; restoration; therapy outcome; tool; wireless; Action Potentials; Adverse effects; Animals; Chemical-Induced Change; Clinic; Clinical Trials; Coupled; Development; Device Designs; Devices; Electric Stimulation; Electrodes; Electrons; Exercise; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Generations; Goals; Human; Hydrogels; In Vitro; Ions; Lead; Mission; Modality; Modeling; Motor; Motor Neurons; Muscle; Muscle function; Muscle rehabilitation; Muscular Atrophy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; Outcome; Patients; Peripheral nerve injury; Protocols documentation; Public Health; Quality of life; Rattus; Reaction; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Research; Safety; Sensory; Signal Transduction; System; Technology; Temperature; Testing; Therapeutic; Tissues; Treatment Efficacy; base; effective therapy; efficacy evaluation; improved; in vivo; motor recovery; muscular structure; muscular system; novel; pre-clinical; preservation; prevent; restoration; therapy outcome; tool; wireless

Project Summary: Muscle electrical stimulation (EStim) is a promising rehabilitation modality for denervated muscles after peripheral nerve injuries. Current muscle EStim devices have limited therapeutic efficacy due to the low EStim intensity they apply. Applying high-intensity EStim to muscles presents a significant challenge. This is because all current devices conduct electron currents. Electrochemical reactions are required to convert the electron currents to the ion currents at the device-tissue interface. These reactions can induce chemical changes and temperature increase that can damage tissues when the EStim intensity is high. Thus, there is a critical need for a new generation of muscle stimulators that can safely apply high-intensity EStim for efficacious preservation of denervated human muscles. The long-term goal is to develop efficacious EStim-based therapy to preserve denervated human muscles after peripheral nerve injuries. The overall objectives of this proposal is to develop a novel EStim device that can safely apply high-intensity EStim to improve the preservation of denervated muscles. In Specific Aim 1, we will determine the optimal EStim device design for safe application of high-intensity EStim. Our working hypothesis is that a wirelessly coupled, ion current-conducting hydrogel ionic circuit (HIC) device does not induce any electrochemical reactions, so it can minimize adverse effects when applying high-intensity EStim. In Specific Aim 2, we will determine the efficacy of high-intensity EStim applied by our device for the preservation of denervated muscles using a pre-clinical rat peripheral nerve injury model. Our working hypothesis is that high- intensity EStim can improve muscle preservation compared to the low-intensity EStim typically used in current studies. The sensory recovery, motor recovery and muscle quality will be evaluated. The rationale for this project is that the development of a wirelessly coupled, completely ion current-based stimulator will significantly increase the EStim intensity that can be applied without causing tissue damage. This will lead to improved muscle rehabilitation outcomes following peripheral nerve injury that is not possible with current stimulators. Our outcome will establish an optimal device design to enable safe and efficient high- intensity EStim application. We will also demonstrate the in vivo efficacy of high-intensity EStim protocol for muscle preservation. Our high impact project will provide a strong justification for further development and testing of our device for treating denervated human muscles following peripheral nerve injuries. This will ultimately lead to better rehabilitation outcomes and improved quality of life for patients suffering from peripheral nerve injury.

项目摘要：肌肉电刺激（估计）是一种有希望的康复方式 周围神经损伤后的肌肉。当前的肌肉估算设备由于 它们应用的低估计强度。对肌肉进行高强度估计提出了重大挑战。 这是因为所有当前设备都会传导电子电流。需要电化学反应才能转换 设备组织接口处的电子电流到离子电流。这些反应可以诱导化学 估计强度高时会损害组织的变化和温度升高。因此，有一个 对新一代肌肉刺激器的批判性需求，这些肌肉刺激剂可以安全地应用高强度估算有效性 保存被剥夺的人类肌肉。 长期目标是开发有效的基于估计的疗法，以保留未经估计的人类肌肉 周围神经损伤。该提案的总体目标是开发一种新颖的估计设备，可以 安全地应用高强度的估计以改善无肌肉的保存。在特定目标1中，我们将 确定用于安全应用高强度估算的最佳估计设备设计。我们的工作假设 是无线耦合的，离子电流导入的水凝胶离子电路（HIC）设备不会引起任何 电化学反应，因此在应用高强度估计时可以最大程度地减少不良反应。具体 AIM 2，我们将确定我们设备用于保存的高强度估计的功效 使用临床前大鼠外围神经损伤模型来取代肌肉。我们的工作假设是 与当前通常使用的低强度估计相比，强度估计可以改善肌肉的保存 研究。将评估感觉恢复，运动恢复和肌肉质量。 该项目的理由是开发一个无线耦合，完全基于离子的电流 刺激器将显着提高可以施加的估计强度，而不会导致组织损伤。这 在周围神经损伤之后，将导致改善肌肉康复结果，这是不可能的 当前的刺激器。我们的结果将建立最佳设备设计，以实现安全有效的高度高效 强度估计应用。我们还将证明高强度估算方案的体内功效 肌肉保存。我们的高影响力项目将为进一步开发和测试提供强有力的理由 我们的设备用于治疗周围神经损伤后未经许可的人类肌肉。这最终将领导 为患有周围神经损伤的患者改善康复结果和改善生活质量。