Implicit Structural Priming as a Treatment Component in Aphasia

内隐结构启动作为失语症的治疗组成部分

• 批准号: 10445227
• 负责人: Jiyeon Lee
• 金额: $ 65.84万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445227
• 关键词: Affect; Aphasia; Assessment tool; Clinical; Communication; Comprehension; Data; Development; Eye; Goals; Heart; Impairment; Intervention; Language; Language Development; Learning; Linguistics; Maintenance; Measures; Modality; Modeling; Outcome; Outcome Measure; Participant; Persons; Phase; Process; Production; Psycholinguistics; Recovery; Reporting; Research; Retrieval; Speech; Stimulus; Structure; System; Testing; Training; Treatment Protocols; Work; aphasia recovery; aphasia rehabilitation; base; design; efficacy study; efficacy testing; experience; experimental study; follow-up; improved; novel; sample fixation; syntax; theories; tool

Project Summary Implicit Structural Priming as a Treatment Component in Aphasia Impaired message-to-structure mapping is at the heart of communication deficits in persons with aphasia (PWA), resulting in impaired sentence production and comprehension. As of yet, the few treatment options available for the mapping deficits involve explicit metacognitive training of sentence production, yielding variable generalization and maintenance effects. Therefore, there remains a critical need to identify interventions that successfully improve mapping abilities in PWA. This project introduces implicit structural priming as a novel facilitator for language recovery in aphasia. Structural priming, a tendency to repeat or better process a current sentence because of its structural similarity to a previously experienced (“prime”) sentence, has been ubiquitously observed across decades of psycholinguistic research and viewed as a powerful tool to study the processes of implicit language learning. Preliminary studies reported in this application suggest that structural priming can be applied to PWA and might produce positive, enduring language recovery in PWA. The planned studies seek to test the hypothesis that implicit structural priming alters the central syntactic system in PWA, creating lasting and generalized improvements in both language production and comprehension. Aim 1 will determine the extent to which different manipulations of structural priming conditions modulate immediate and long-term improvement in sentence production. We integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced syntactic learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, we investigate whether the effects of structural priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross- modality generalization. In Aim 3, we develop and establish Phase I efficacy data of an implicit structural priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The outcomes of this work will lead to identification of a model of language (re-)learning in aphasia and the development of a novel treatment that capitalizes on the benefits of the implicit learning mechanisms underlying structural priming.

项目摘要 隐性结构启动作为失语症的治疗部分 消息到结构映射受损是与人际交流防御的核心 失语（PWA），导致句子的产生和理解力受损。到目前为止，第二 映射定义可用的治疗选项涉及对句子的明确元认知培训 生产，产生可变的概括和维护效果。因此，仍然有关键 需要确定成功提高PWA映射能力的干预措施。这个项目 引入了隐式结构启动，作为失语症中语言恢复的新型促进者。结构 启动，是重复或更好地处理当前句子的趋势，因为它的结构相似性与 在数十年中，以前经验丰富的（“ Prime”）句子被普遍存在 心理语言研究，被视为研究隐性语言过程的强大工具 学习。该应用中报道的初步研究表明，结构启动可以应用 到PWA，可能会在PWA中产生积极的语言恢复。计划的研究试图 检验隐性结构启动的假设改变了PWA中的中央句法系统，创造了 语言生产和理解的持久和广泛改进。目标1意志 确定结构启动条件的不同操作调节的程度 句子生产的立即和长期改善。我们整合了多种理论 语言学习并应用它们以对启动引起的句法的轨迹进行预测 在PWA中学习。在AIM 2中，使用一组眼影式的句子理解任务，我们调查 生产中结构启动的影响是否概括为离线（准确性）和在线（眼睛） 固定）句子理解并确定哪些学习条件会导致更大的交叉 模态概括。在AIM 3中，我们开发并建立了隐性的I阶段效率数据 结构性启动处理，增加了支持最大保留率的关键学习条件 从目标1和2。这项工作的结果将导致识别一种语言模型 （重新）在失语症中学习和开发一种新颖的治疗方法，该治疗利用了 结构启动的隐式学习机制。