Implicit Structural Priming as a Treatment Component in Aphasia

内隐结构启动作为失语症的治疗组成部分

• 批准号: 10445227
• 负责人: Jiyeon Lee
• 金额: $ 65.84万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445227
• 关键词: Affect; Aphasia; Assessment tool; Clinical; Communication; Comprehension; Data; Development; Eye; Goals; Heart; Impairment; Intervention; Language; Language Development; Learning; Linguistics; Maintenance; Measures; Modality; Modeling; Outcome; Outcome Measure; Participant; Persons; Phase; Process; Production; Psycholinguistics; Recovery; Reporting; Research; Retrieval; Speech; Stimulus; Structure; System; Testing; Training; Treatment Protocols; Work; aphasia recovery; aphasia rehabilitation; base; design; efficacy study; efficacy testing; experience; experimental study; follow-up; improved; novel; sample fixation; syntax; theories; tool

Project Summary Implicit Structural Priming as a Treatment Component in Aphasia Impaired message-to-structure mapping is at the heart of communication deficits in persons with aphasia (PWA), resulting in impaired sentence production and comprehension. As of yet, the few treatment options available for the mapping deficits involve explicit metacognitive training of sentence production, yielding variable generalization and maintenance effects. Therefore, there remains a critical need to identify interventions that successfully improve mapping abilities in PWA. This project introduces implicit structural priming as a novel facilitator for language recovery in aphasia. Structural priming, a tendency to repeat or better process a current sentence because of its structural similarity to a previously experienced (“prime”) sentence, has been ubiquitously observed across decades of psycholinguistic research and viewed as a powerful tool to study the processes of implicit language learning. Preliminary studies reported in this application suggest that structural priming can be applied to PWA and might produce positive, enduring language recovery in PWA. The planned studies seek to test the hypothesis that implicit structural priming alters the central syntactic system in PWA, creating lasting and generalized improvements in both language production and comprehension. Aim 1 will determine the extent to which different manipulations of structural priming conditions modulate immediate and long-term improvement in sentence production. We integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced syntactic learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, we investigate whether the effects of structural priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross- modality generalization. In Aim 3, we develop and establish Phase I efficacy data of an implicit structural priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The outcomes of this work will lead to identification of a model of language (re-)learning in aphasia and the development of a novel treatment that capitalizes on the benefits of the implicit learning mechanisms underlying structural priming.

项目概要 内隐结构启动作为失语症的治疗组成部分 消息到结构映射受损是患有以下疾病的人沟通缺陷的核心 失语症（PWA），导致句子产生和理解受损。 针对映射缺陷的可用治疗方案包括对句子进行显式元认知训练 因此，仍然存在一个关键的问题。 需要确定能够成功提高 PWA 绘图能力的干预措施。 引入内隐结构启动作为结构性失语症语言恢复的新型促进剂。 启动，由于其结构相似而重复或更好地处理当前句子的倾向 一个以前经历过的（“主要”）句子，在几十年来已经被普遍观察到 心理语言学研究并被视为研究内隐语言过程的有力工具 本申请中报告的初步研究表明可以应用结构启动。 计划中的研究旨在促进 PWA 的发展，并可能在 PWA 中产生积极、持久的语言恢复。 检验隐式结构启动改变 PWA 中的中心句法系统的假设，创建 目标 1 将在语言产生和理解方面实现持久和普遍的改进。 确定结构启动条件的不同操作的调节程度 我们整合了多种理论来提高句子的生成。 语言学习并应用它们来预测启动引起的句法轨迹 在目标 2 中，我们使用一组眼球追踪句子理解任务进行了研究。 生产中结构启动的影响是否推广到离线（准确性）和在线（眼睛） 固定点）句子理解并确定哪些学习条件会导致更大的交叉 在目标 3 中，我们开发并建立了隐式模型的 I 期疗效数据。 结构启动治疗，纳入支持最大保留的关键学习条件 来自目标 1 和 2。这项工作的成果将导致语言模型的识别 失语症的（重新）学习以及利用以下益处的新型治疗方法的开发 结构启动背后的内隐学习机制。