Neurodevelopmental and Cognitive Mechanisms Linking Unpredictable Maternal Care to Risk for Socioemotional Problems

神经发育和认知机制将不可预测的产妇护理与社会情感问题的风险联系起来

基本信息

批准号：
10311809
负责人：
Kelli Lynn Dickerson
金额：
$ 6.83万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10311809
关键词：
5 year old Address Age Amygdaloid structure Animal Model Award Behavior Behavioral Birth Brain Caregivers Caring Child Child Development Child Health Cognitive Data Data Collection Development Economics Electroencephalogram Emotional Employment Environment Event-Related Potentials Experimental Designs Exposure to Family Foundations Frequencies Future Hippocampus (Brain)Human Impairment Intervention Investigation Knowledge Lead Learning Life Experience Link Literature Longitudinal cohort Marital Status Maternal Behavior Mediating Memory Methods Monitor National Institute of Child Health and Human Development Neurobiology Neurophysiology - biologic function Pathway interactions Pattern Performance Play Policies Population Poverty Prevention Public Health Reaction Time Recording of previous events Research Rest Risk Rodent Rodent Model Role Sensory Shapes Signal Transduction Social Behavior Source Strategic Planning Stress Testing Training Uncertainty attentional control career caregiving cognitive function cognitive process developmental psychology early childhood early life stress emotional functioning executive function experience human model insight neural circuit neural patterning novel programs pup relating to nervous system residence social

项目摘要

Project Summary/Abstract The caregiving environment constitutes one of the most significant sources of early life experience for children. Early interactions with caregivers provide essential inputs that shape the developing brain and lay the foundation for children’s future social, emotional, and intellectual functioning. While an extensive body of work highlights the quality of early caregiver-child interactions (including caregiver sensitivity and responsiveness) as a key contributor to child health and development, emerging evidence suggests that the predictability of these interactions may also play a powerful role in shaping child development, especially within socioemotional domains. The strongest evidence for this claim comes from rodent models, which increasingly associate unpredictable maternal behavior with pervasive socioemotional impairments in rodent pups, and these impairments appear dependent on alterations in neural circuitry governing cognitive and emotional function (i.e., prefrontal-hippocampal-amygdala circuits). Recent behavioral evidence from human research also supports associations between unpredictable maternal behavior and impaired socioemotional functioning in children, including elevated risk for externalizing problems and reduced prosociality. However, the mechanisms underlying these associations are not well-understood in children. The proposed studies will integrate insights from animal and human models to directly address this gap in the literature and test potential neurodevelopmental and cognitive mechanisms linking unpredictable maternal care and the emergence of socioemotional problems in young children. Aim 1 will use existing longitudinal data from an investigation of children followed from birth to age 3 to test whether alterations in resting brain function, namely EEG band power and coherence in regions supporting executive function and social behavior, underlie the associations between unpredictable maternal behavior and children’s risk for subsequent externalizing problems. Aim 2 will involve an experimental test of whether deficits in neural and behavioral markers of executive function also contribute to associations between unpredictable maternal behavior and both externalizing problems and reduced prosociality in 4- to 5-year-old children. Together, findings will provide new insight into mechanisms linking unpredictable early caregiver inputs and socioemotional problems and may provide critical new direction to prevention and intervention efforts aimed at promoting healthy socioemotional development in children. This award will provide the candidate, who has a strong background in developmental psychology, with training in neurobiology and the use of EEG and ERP methods that will facilitate her transition into an independent research career.

项目概要/摘要照料环境是儿童早期生活经历的最重要来源之一。与照顾者的早期互动提供了塑造大脑发育并奠定基础的重要输入。为儿童未来的社交、情感和智力功能奠定基础，同时进行大量的工作。强调早期看护者与儿童互动的质量（包括看护者的敏感性和反应能力）作为儿童健康和发展的关键因素，新出现的证据表明，这些互动也可能在塑造儿童发展方面发挥重要作用，特别是在社会情感方面这一说法最有力的证据来自啮齿动物模型，它们之间的联系越来越紧密。不可预测的母亲行为以及啮齿动物幼崽普遍存在的社会情感障碍，以及这些损伤似乎取决于控制认知和情绪功能的神经回路的改变（即前额叶-海马-杏仁核回路）也来自人类研究的最新行为证据。支持不可预测的母亲行为与受损的社会情绪功能之间的联系儿童，包括外化问题的风险增加和亲社会性降低。这些关联背后的机制在儿童中尚不清楚。整合动物和人类模型的见解，直接解决文献中的这一空白并测试潜力将不可预测的产妇护理与出现的神经发育和认知机制联系起来目标 1 将使用来自调查的现有纵向数据。对儿童从出生到 3 岁进行跟踪，以测试静息大脑功能（即脑电图带）是否发生变化支持行政职能和社会行为的区域的权力和一致性是协会的基础目标 2 将在不可预测的母亲行为与儿童随后发生外化问题的风险之间进行比较。涉及一项实验测试，以确定执行功能的神经和行为标志物的缺陷是否也存在导致不可预测的母亲行为与外部化问题和 4 至 5 岁儿童的亲社会性降低，这些研究结果将为机制提供新的见解。将不可预测的早期护理人员投入和社会情感问题联系起来，可能会提供重要的新信息旨在促进健康社会情感发展的预防和干预工作方向该奖项将为具有发展心理学背景的候选人提供，通过神经生物学培训以及脑电图和 ERP 方法的使用，这将有助于她转变为独立的研究生涯。