Cherokee Nation Native AmericanResearch Center for Health

切罗基族美洲原住民健康研究中心

• 批准号: 10293108
• 负责人: SOHAIL Imran KHAN
• 金额: $ 131.75万
• 依托单位: CHEROKEE NATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293108
• 关键词: Address; Adult; Alaska Native; American Indians; Area; Biological Sciences; Businesses; COVID-19; COVID-19 impact; COVID-19 point of care; COVID-19 prevention; COVID-19 risk; COVID-19 testing; Cherokee Indian; Cherokee Nation, Oklahoma; Clinic; Clinical Research; Communities; Community Surveys; Contact Tracing; County; Data; Data Reporting; Disease; Disease Outbreaks; Education; Educational Materials; Effectiveness; Electronic Health Record; Ensure; Ethics; Ethnic group; Evaluation; Event; FDA Emergency Use Authorization; Foundations; Future; Geography; Health; Health Sciences; Health Service Area; Health Services; Health system; Hepatitis C virus; Human Resources; Immunoassay; Immunologic Markers; Indian reservation; Inflammatory; Infrastructure; Interview; Laboratory Personnel; Lateral; Leadership; Medical; Medical Research; Modeling; Molecular; Monitor; Native-Born; Oklahoma; Outcome; Patient Education; Patients; Perception; Persons; Population; Populations at Risk; Poverty; Prevalence; Public Health; RADx; RADx Underserved Populations; Reporting; Reservations; Risk; Risk Factors; Rural; Rural Community; Rural Population; SARS-CoV-2 antibody; Schools; Serum; Site; Solid; Testing; Travel; Underserved Population; Universities; Vaccination; Viral; Viral Antibodies; Writing; aged; base; biobank; clinical care; community barrier; community engagement; community transmission; comorbidity; design; experience; geographic barrier; human subject; informant; insight; instrument; novel; point of care testing; programs; protective factors; public health intervention; racial and ethnic; respiratory; respiratory pathogen; rural area; screening; severe COVID-19; social implication; testing uptake; tribal health; tribal member

PROJECT SUMMARY Through the RADx-UP program, the Cherokee Nation Community-Driven Program for Testing and Contact Tracing (Cherokee PROTECT) unites tribal, academic, and community partners under the leadership of Cherokee Nation (CN) to solve a dire need for COVID-19 testing, contact tracing, and culturally informed education in underserved and vulnerable rural populations. As of August 4, Cherokee Nation Health Services (CNHS) has confirmed >850 cases of COVID-19 in the tribal populations served across mainly rural northeastern Oklahoma. Community spread of COVID-19 exists throughout all 14 counties in the CN reservation, but with CN’s limited capacity for community testing, screening, and contact tracing, the true impact of COVID-19 is unknown. Roughly 34% of American Indian/Alaska Native (AI/AN) adults aged 18-64 years are at risk of severe COVID-19 due to comorbidities, more than any other racial/ethnic group in the US. Five counties in CN are in the top 20% of US counties for the prevalence of adults at risk of severe COVID-19 due to underlying medical conditions; this vulnerability is compounded by high poverty rates and geographic barriers. People living in rural areas of CN may have to travel as many as 60 miles round-trip for viral testing. Most COVID-19 testing in CN to date has been conducted through CNHS, the largest tribally compacted health system in the US that serves all AI/AN people living within the CN reservation. Although CNHS accounts for approximately 8.5% of all IHS active user population and 38% of active user population of Oklahoma service area, not all tribal members residing in the reservation access CNHS, and therefore, may not be tested by CNHS. Other than CNHS clinics, 7 of 14 counties in this area have only one public testing site, and results may not be returned for 2-3 weeks. CNHS and its closely integrated CN Public Health program have an exemplary 20-year record of delivering public health interventions, including a groundbreaking Hepatitis C Virus elimination program with the University of Oklahoma Health Sciences Center, and ongoing projects with >40 rural K-12 schools. Through collaborative clinical research and molecular studies, CN and the Oklahoma Medical Research Foundation have identified new immune biomarkers in tribal populations. Drawing on these existing strengths and infrastructure, Cherokee PROTECT will (1) Build infrastructure and increase FDA-EUA COVID-19 viral and antibody testing for clinical care in CNHS; (2) Enable community-based COVID-19 testing, contact tracing, and education with CN Public Health; (3) Identify barriers and facilitators to COVID-19 testing in the CN reservation to inform a tailored educational campaign to increase testing and contact tracing, and decrease spread; and (4) Implement a rigorous evaluation to ensure quality improvement and sustainability.

项目摘要 通过RADX-UP计划，切诺基国家社区驱动的测试和联系计划 追踪（切诺基保护）在部落，学术和社区合作伙伴的领导下 切诺基国家（CN）解决了对19 covid-19测试，联系跟踪和文化知情的迫切需求 在服务不足和脆弱的农村人群中进行教育。截至8月4日，切诺基国家卫生服务 （CNHS）已确认在主要农村服务的部落人口中确认了> 850例COVID-19 俄克拉荷马州东北部。 COVID-19的社区蔓延在CN的所有14个县中都存在 保留，但CN的社区测试，筛选和联系跟踪的能力有限，真实 COVID-19的影响尚不清楚。大约34％的美洲印第安人/阿拉斯加本地人（AI/AN）成年人18-64岁 由于合并症，年龄比美国其他任何种族/族裔群体都有严重的Covid-19。 CN中的五个县在美国县的前20％，因为成年人患有严重的Covid-19 由于基本的医疗状况；高贫困率和地理位置使这种脆弱性更加复杂 障碍。居住在CN的粗糙地区的人们可能不得不旅行多达60英里的往返病毒测试。 迄今为止，CN的大多数COVID-19测试是通过CNHS进行的，CNH是最大的部落紧凑型健康 美国的系统为所有居住在CN保留中的人/一个人提供服务。尽管CNHS占 大约8.5％的IHS活跃用户人数和俄克拉荷马州活跃用户服务的38％ 区域，并非所有居住在预订访问CNHS中的部落成员，因此不得通过 CNHS。除CNHS诊所外，该地区14个县中有7个只有一个公共测试地点，结果可能 不返回2-3周。 CNHS及其紧密整合的CN公共卫生计划有一个模范 提供公共卫生干预措施的20年记录，包括开创性的乙型肝炎病毒 俄克拉荷马大学健康科学中心的淘汰计划，以及持续的项目> 40 农村K-12学校。通过协作临床研究和分子研究，CN和俄克拉荷马州 医学研究基金会已经确定了部落人口中的新免疫生物标志物。利用这些 现有的优势和基础设施，切诺基保护（1）建立基础设施并增加FDA-EUA COVID-19的CNH临床护理病毒和抗体测试； （2）启用基于社区的Covid-19测试， 与CN公共卫生进行联系和教育； （3）确定COVID-19测试的障碍和促进因子 在CN保留中，以告知量身定制的教育运动，以增加测试和接触跟踪，并 减少传播； （4）实施严格的评估，以确保质量提高和可持续性。

项目成果

Unique Serum Immune Phenotypes and Stratification of Oklahoma Native American Rheumatic Disease Patients.

俄克拉荷马州美洲原住民风湿病患者的独特血清免疫表型和分层。

• DOI: 10.1002/acr.24795
• 发表时间: 2023
• 期刊: Arthritis care & research
• 影响因子: 4.7
• 作者: Slight-Webb,Samantha;Guthridge,CarlaJ;Kheir,Joseph;Chen,Hua;Tran,Ly;Gross,Tim;Roberts,Virginia;Khan,Sohail;Peercy,Michael;Saunkeah,Bobby;Guthridge,JoelM;James,JudithA
• 通讯作者: James,JudithA

Development and Implementation of an HPV Vaccination Survey for American Indians in Cherokee Nation.

• DOI: 10.3390/ijerph18179239
• 发表时间: 2021-09-01
• 期刊: International journal of environmental research and public health
• 作者: Gopalani SV;Janitz AE;Burkhart M;Campbell JE;Martinez SA;White AH;Chen S;Anderson AS;Pharr SF;Patrick S;Comiford A
• 通讯作者: Comiford A