Shared Resource: Laboratory Animal Facility

共享资源：实验动物设施

基本信息

批准号：
10427541
负责人：
Christin Veeder
金额：
$ 2.34万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10427541
关键词：
Abbreviations Accreditation Advisory Committees Animal Experimentation Animal Housing Animal Husbandry Animal Model Animal Welfare Animals Antibodies Award Bioinformatics Biological Biological Assay Biological Models Biological Specimen Banks Biometry Blood Cells Bone Marrow Transplantation Breeding Cancer Biology Cancer Center Cancer Center Support Grant Cancer Control Caring Cell Culture Techniques Cell Separation Cesarean section Communicable Diseases Comprehensive Cancer Center Consultations Data Collection Detection Development Doctor of Philosophy Embryo Transfer Ensure Enzymes Epigenetic Process Equipment Fox Chase Cancer Center Foxes Funding Genes Genetic Genomics Germ-Free Health Health Services Health system Hematopoiesis Hematopoietic Histopathology Facility Immunocompetent Immunocompromised Host Immunooncology Impairment Infectious Agent Interleukin-6 International Interruption Investments Knowledge Laboratory Animal Shared Resource Laboratory Animals Leadership Link Malignant Neoplasms Mammals Medical Research Modeling Modification Molecular Mus NCI Center for Cancer Research Organism Oryctolagus cuniculus Parents Peer Review Pharmaceutical Preparations Polymerase Chain Reaction Population Study Procedures Protocols documentation Rana Rattus Recommendation Reporting Research Research Personnel Resource Sharing Resources Risk Rodent Science Services Site Surveillance Program Therapeutic Tissue Banks Transgenic Mouse Facility Transgenic Organisms Travel Treatment Protocols United States Department of Agriculture Universities University Hospitals Zebrafish animal care animal facility cancer prevention cell type comparative cost cost effective cost efficient experience gene discovery guide for the care and use of laboratory animals high throughput screening imaging facilities in vivo laboratory facility medical schools member molecular modeling pathogen patient derived xenograft model peer support programs skills square foot translational model

项目摘要

MODEL SYSTEMS SHARED RESOURCE: LABORATORY ANIMAL FACILITY (LAF) PROJECT SUMMARY/ABSTRACT The Laboratory Animal Facility (LAF) allows the creation and use of translational animal models to facilitate research for Cancer Center members. The animal care program at FCCC has been fully accredited by AAALAC International since 1969 and has been awarded Emeritus status. The LAF is in full compliance with regulatory agencies including the Drug Enforcement Administration, United States Department of Agriculture, and Office of Laboratory Animal Welfare. Under the direction of Hilton Klein, VMD and with the support of 16 LAF management and technical staff, the LAF provides animal husbandry and animal support services for Cancer Center members who require mice, rabbits, frogs or other rodents for their research. Under the direction of Jennifer Rhodes, PhD, and the support of a scientific technician, a new Zebrafish service line is now available to Cancer Center members. Zebrafish are an ideal model to discover genes that are essential for hematopoietic development in vivo. The spectrum of blood cell types and the genes known to regulate normal hematopoiesis are well conserved between zebrafish and mammals, suggesting that the regulatory mechanisms directing lineage specification and differentiation are similar across vertebrate species. 38 Cancer Center members used the LAF in 2014. 95% of the mouse cages occupied in 2014 supported the science of investigators with peer-reviewed funding. 100% of the use of zebrafish services was in support of peer-review funded investigators in 2014. For the period 2011-2014, the LAF was utilized by 55 Cancer Center members from all five Research Programs. A Comparative Medical Research Building was constructed during the last cycle at a cost of $14M. ARRA funds of $8M were matched with institutional investment of $6M. This new vivarium adjoins the existing LAF building and provides an additional 12,511 net square feet for animal housing and procedures. FCCC invested $765,783 in renovations and equipment to make zebrafish services available. An on-site, centralized LAF is cost efficient and critical to the peer-reviewed, funded research programs at FCCC. The research animals and animal care staff are readily available to investigators and modifications in breeding, husbandry, or treatment protocols can be readily accomplished reducing any delay or misinterpretation. Although an off-site commercial facility could conceivably supply and care for FCCC research animals, the inconvenience to the investigators in both travel and transporting animals to and from FCCC would be a serious impairment to research. The majority (90%) of the approved animal use protocols involve at least weekly, in some instances daily, observations, data, or tissue collections by the research staff. The LAF is advised by a dedicated Facility Advisory Committee (FAC) that meets at least annually. FAC recommendations are directed to a governing Facility Parent Oversight Committee (FPOC), which serves to ensure that the LAF continues to have the necessary resources to provide the highest quality services. The FPOC issues reports to senior leadership.

模型系统共享资源：实验室动物设施（LAF）项目摘要/摘要实验室动物设施（LAF）允许创建和使用转化动物模型来促进癌症中心成员的研究。 FCCC的动物护理计划已得到完全认可自1969年以来，AAAALAC International已获得名誉身份。 LAF完全符合美国农业部毒品执法局在内的监管机构，和实验室动物福利办公室。在希尔顿·克莱因（Hilton Klein）的指导下，在VMD和16的支持下 LAF管理和技术人员，LAF为畜牧业和动物支持服务提供需要小鼠，兔子，青蛙或其他啮齿动物进行研究的癌症中心成员。在詹妮弗·罗德斯（Jennifer Rhodes），博士和科学技术员的支持，新的斑马鱼服务线现在可供癌症中心成员使用。斑马鱼是发现必不可少的基因的理想模型体内造血发育。血细胞类型的光谱和已知的调节基因正常的造血在斑马鱼和哺乳动物之间很好地保守，表明调节指导谱系规范和分化的机制在脊椎动物物种之间相似。 38 癌症中心成员在2014年使用LAF。2014年占据的老鼠笼子中有95％支持通过同行评审资金的调查人员科学。斑马鱼服务的100％支持同行评审于2014年为调查人员提供了所有五个研究计划的中心成员。建造了比较医学研究大楼在最后一个周期中，成本为1400万美元。 800万美元的ARRA资金与600万美元的机构投资相匹配。这个新的Vivarium毗邻现有的LAF大楼，并为额外的12,511净平方英尺提供动物住房和程序。 FCCC投资了765,783美元的装修和设备，以制造斑马鱼可用的服务。现场的集中式LAF具有成本效益，对经过同行评审的资助至关重要 FCCC的研究计划。研究人员很容易获得研究动物和动物护理人员可以轻易完成育种，饲养或治疗方案的修改，以减少任何延迟或误解。尽管现场商业设施可以想象可以提供和照顾 FCCC研究动物，对旅行和将动物运送到和运输的调查人员给和来自FCCC将是研究的严重损害。大多数（90％）批准的动物使用在某些情况下，协议至少每周涉及每周，观察，数据或组织收集。研究人员。 LAF由专门的设施咨询委员会（FAC）告知，至少会见每年。 FAC建议针对管理机构父母监督委员会（FPOC），这有助于确保LAF继续拥有必要的资源来提供最高质量服务。 FPOC向高级领导层报告报告。