Examining Modifiable Psychosocial Predictors of HIV Seroconversion in a Large Nationwide Cohort of High Risk Men

检查全国范围内大量高危男性中 HIV 血清转化的可修改心理社会预测因素

• 批准号: 10415523
• 负责人: H. Jonathon Rendina
• 金额: $ 86.78万
• 依托单位: WHITMAN-WALKER INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415523
• 关键词: AIDS prevention; Age; Behavior; Biological; Bisexual; Child Sexual Abuse; Chlamydia; Chlamydia Infections; Cohort Studies; Color; Development; Discrimination; Distal; Enrollment; Environment; Epidemic; Epidemiology; Ethnic Origin; Future; Gays; Geographic Locations; Goals; Gonorrhea; HIV; HIV Infections; HIV Seropositivity; HIV risk; HIV/STD; Incidence; Income; Individual; Infection; Intervention; Lead; Link; Measures; Mental Depression; Mental Health; Minority; Modeling; Outcome; Patient Self-Report; Population; Predisposition; Prevalence; Prevention Research; Prevention program; Procedures; Puerto Rico; Race; Research; Research Personnel; Risk; Risk Behaviors; Risk Factors; Sexual Health; Sexual Partners; Sexually Transmitted Diseases; Stress; Structure; Subgroup; Testing; Time; Validity and Reliability; Work; aged; base; behavior change; cohort; condomless anal sex; design; disparity reduction; experience; high risk; high risk men; high risk population; improved; infection rate; infection risk; interest; intimate partner violence; men; men who have sex with men; mobile application; morphogens; next generation; polysubstance use; predictive modeling; preventive intervention; prospective; psychosocial; recruit; rectal; response; seroconversion; sexual minority; stressor; substance use; willingness

Project Summary Gay, bisexual and other men who have sex with men (GBMSM) remain a population in the U.S. for whom the burden of HIV is high and disproportionate, particularly among younger GBMSM and GBMSM of color, for whom HIV incidence continues to rise despite decades of HIV prevention research to curb the epidemic. However, even among these highest risk groups, risk for infection is not equivalent and the goal of this study is to better understand what factors differentiate levels of risk for HIV infection. Research to date suggests that this disproportionate burden is likely to be exacerbated by psychosocial disparities faced by this population in the form of syndemics and sexual minority stress. However, research on these factors has been limited by a focus on risk for HIV infection operationalized as risk behavior or cross-sectional prevalence of HIV, making actual vulnerability to infection and temporal associations difficult, if not impossible, to determine. We are submitting this application in response to RFA-AI-16-031 Limited Interaction Targeted Epidemiology (LITE) to Advance HIV Prevention (UG3/UH3). We propose to recruit and enroll a large and diverse cohort of approximately 8,000 GBMSM ages 16 and older in the U.S. and Puerto Rico who are at high risk for infection. We will utilize mobile sexual networking applications (“mobile apps”) to identify and enroll these men both to allow for rapid and efficient recruitment and because these apps rapidly increasing in popularity, with research demonstrating that men who use mobile apps are at higher levels of risk for HIV infection than GBMSM recruited through other means. Using this cohort, we will work to achieve three primary aims: (1) we will establish HIV prevalence as well as prevalence of rectal sexually transmitted infections (STIs; gonorrhea and chlamydia) at baseline and subsequently establish rates of HIV and rectal STI incidence among these men 12 months thereafter; (2) we will utilize baseline levels of syndemic, minority stress, and other relevant psychosocial risk factors to develop a model of those modifiable factors that contribute to increased risk for HIV seroconversion (i.e., incidence) as well as rectal STI infection; (3) we will utilize the model to target men in the highest quartile of risk for HIV seroconversion in the cohort and follow them every 6 months thereafter for an additional two years to examine the predictive utility in prospectively predicting HIV seroconversion as well as time to seroconversion. Developing a model of modifiable psychosocial risk factors for actual HIV seroconversion and subsequently testing its reliability and validity in a prospective design has high potential to improve the next generation of HIV prevention interventions aimed at reducing disparities for this population.

项目摘要 同性恋，双性恋和其他与男人发生性关系的男人（GBMSM）仍然是美国的人口 艾滋病毒的伯恩（Burnen of HIV）高且不比例地 艾滋病毒事件继续增加，几十年来，预防艾滋病毒预防研究以遏制流行病。 但是，即使在这些最高风险群体中，感染的风险也不相同，这项研究的目的是 更好地了解哪些因素会区分艾滋病毒感染的风险水平。迄今为止的研究表明 这种不成比例的伯恩可能会因该人群所面临的心理差异而加剧 集团和性少数压力的形式。但是，对这些因素的研究受到了 专注于艾滋病毒感染的风险，以风险行为或艾滋病毒的横截面患病率进行操作，使 实际的感染和临时关联的脆弱性很难（即使不是不可能）确定。我们是 根据RFA-AI-16-031提交此申请，有限的相互作用针对性流行病学（LITE） 预防艾滋病毒（UG3/UH3）。我们建议招募和注册大量多样的队列 在美国，大约有8,000名GBMSM年龄在16岁及以上的GBMSM和处于高风险感染风险的波多黎各。 我们将利用移动性网络应用程序（“移动应用程序”）来识别和注册这些男人 随着研究 证明使用移动应用的男性比GBMSM更高的HIV感染风险水平 通过其他方式招募。使用此队列，我们​​将努力实现三个主要目标：（1）我们将 建立艾滋病毒患病率以及直肠性传播感染的患病率（stis;淋病和 衣原体）在基线时，随后确定了这些男子的艾滋病毒和直肠性传播疾病的发生率12 此后几个月； （2）我们将利用集团，少数族裔压力和其他相关的基线水平 社会心理风险因素开发出那些可修改因素的模型，这些因素导致艾滋病毒风险增加 血清转化（即发病率）以及直肠性STI感染； （3）我们将利用该模型来针对男人 在同类中，艾滋病毒血清转化风险的最高四分位数，此后每6个月跟随它们 在预测HIV血清转化以及 时间到达血清转换。为实际的艾滋病毒开发一种可修改的社会心理风险因素的模型 血清转化并随后测试其可靠性和有效性，具有很高的潜力 改善旨在减少该人群差异的下一代HIV预防干预措施。

项目成果

Reactions to Testing HIV Negative: An Assessment of Measurement Invariance and Associations with Condomless Anal Sex among English and Spanish-speaking Latinx Sexual Minority Men in the United States.

对艾滋病毒检测呈阴性的反应：对美国讲英语和西班牙语的拉丁裔性少数男性的测量不变性及其与无套肛交的关联的评估。

• DOI: 10.1007/s10461-023-04081-5
• 发表时间: 2023
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Robles,Gabriel;Lee,JaneJ;Reynolds,Addam;Rodríguez-Díaz,CarlosE;Rendina,HJonathon
• 通讯作者: Rendina,HJonathon

Examining inequities in rates of undiagnosed HIV and rectal STIs in a large nationwide cohort study of sexual minority men.

• DOI: 10.1136/sextrans-2021-055047
• 发表时间: 2022-06
• 期刊: Sexually transmitted infections
• 影响因子: 3.6

Rates of Pre-exposure Prophylaxis Use and Discontinuation Among a Large U.S. National Sample of Sexual Minority Men and Adolescents.

美国全国性少数男性和青少年大型样本中暴露前预防药物的使用和停用率。

• DOI: 10.1007/s10508-019-01602-z
• 发表时间: 2020
• 期刊: Archives of sexual behavior
• 影响因子: 3.8
• 作者: Whitfield,ThomasHF;Parsons,JeffreyT;Rendina,HJonathon
• 通讯作者: Rendina,HJonathon

The Use of HIV Pre- and Postexposure Prophylaxis Among a Web-Based Sample of HIV-Negative and Unknown Status Cisgender and Transgender Sexual Minority Men: Cross-sectional Study.

• DOI: 10.2196/31237
• 发表时间: 2022-12-16
• 期刊: JMIR PUBLIC HEALTH AND SURVEILLANCE
• 影响因子: 8.5
• 作者: John, Steven A.;Sizemore, Marie;Jimenez, Ruben H.;Jones, S. Scott;Petroll, Andrew E.;Rendina, H. Jonathon
• 通讯作者: Rendina, H. Jonathon

Use of the Bio-Rad Geenius HIV-1/2 supplemental assay for the testing of oral fluids for the presence of HIV antibody.

使用 Bio-Rad Geenius HIV-1/2 补充检测检测口腔液中是否存在 HIV 抗体。

• DOI: 10.1016/j.jcv.2020.104422
• 发表时间: 2020
• 期刊: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
• 作者: Elma,Maria;Krusel,Kathryn;Crumpler,Megan;Tavella,Nico;Talan,Ali;Rendina,Jonathon;Pandori,Mark
• 通讯作者: Pandori,Mark