Mentorship of Junior Investigators on HEAL-SKOAP

HEAL-SKOAP 初级研究员的指导

• 批准号: 10426755
• 负责人: Claudia Michelle Campbell
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426755
• 关键词: Adverse effects; Algorithms; Back; Behavioral; Body mass index; COVID-19 pandemic; Caring; Characteristics; Chronic; Clinical; Clinical Trials; Collaborations; Combined Pharmacological and Behavioral Treatment; Coping Skills; Data Coordinating Center; Degenerative polyarthritis; Discipline; Elderly; Environment; Exhibits; Exposure to; Funding; Funding Mechanisms; Goals; Government; Guidelines; Hyaluronic Acid; Individual; Individual Differences; Industry; Injections; Institution; Intervention; Knee Osteoarthritis; Knowledge; Learning; Life Expectancy; Measures; Medical; Medicine; Mental Depression; Mentors; Mentorship; Modeling; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; Nerve Block; Outcome; Pain; Pain management; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Phase; Phase III Clinical Trials; Phenotype; Physical Function; Plants; Population; Positioning Attribute; Postdoctoral Fellow; Prediction of Response to Therapy; Procedures; Publishing; Radiofrequency Interstitial Ablation; Randomized; Randomized Controlled Trials; Research Personnel; Risk; Running; Sample Size; Scholarship; Scientist; Seeds; Senior Scientist; Shapes; Site; Sleep; Time; Training; United States National Institutes of Health; Universities; Utah; base; behavioral pharmacology; biopsychosocial; career; chronic pain; clinical care; clinical pain; collaborative environment; comparative effectiveness; comparative effectiveness study; compare effectiveness; design; duloxetine; effectiveness research; effectiveness testing; experience; flexibility; follow-up; functional disability; functional outcomes; graduate student; improved; improved functioning; improved outcome; innovation; interest; knee pain; knee replacement arthroplasty; mid-career faculty; model design; multidisciplinary; next generation; non-opioid analgesic; novel; opioid sparing; opioid therapy; opioid use; osteoarthritis pain; pain catastrophizing; pain model; pain outcome; pain reduction; personalized medicine; precision medicine; pressure; psychosocial; randomized trial; recruit; resilience; response; senior faculty; skills training; standard of care; success; tenure track; training opportunity; treatment comparison; treatment response

SUMMARY/ABSTRACT The exodus from academic to careers in industry, government and other sectors has been expedited by the COVID-19 pandemic. Given tight funding pay lines, a shortage and fierce completion for tenured and tenure- track university/academic medical institution positions and a ‘publish or perish’ mindset, more and more graduate students, postdoctoral fellows and even residents are looking to leave academic medicine in the pursuit of more stable and lucrative careers. Junior investigators require support, guidance and training opportunities to plant the seeds to develop into- and retain established pain scientists. Unfortunately the current algorithm for mid-career and senior faculty success does not include developing the next generation of leaders within our challenging field of academic medicine. The current funding mechanism is an outstanding opportunity for mentors to devote time, effort and funds towards junior investigators interested in a career in pain scholarship. The current application seeks to provide protected mentorship-focused time for Dr. Claudia Campbell, an MPI on the ‘SKOAP’ phase III clinical trial. The SKOAP study, a Sequenced-strategy for improving outcomes in people with Knee OsteoArthritis Pain, is a sequential large-scale HEAL Effectiveness Research Network study evaluating conservative and nonsurgical procedural interventions for reducing pain and improving function in patients with KOA. The trial is an excellent platform for the training of junior investigators from varied disciplines. The SKOAP trial is designed to mimic clinical care by first testing the effectiveness of conservative treatment and nonsurgical interventional procedures. This large-scale, pragmatic, comparative-effectiveness study involves comprehensive and innovative approaches that have never before been employed in this context, providing an exciting learning platform in multiple domains, including: a multidisciplinary cadre of investigators conducting the largest randomized trial to date to evaluate behavioral, pharmacologic, and procedural interventions for KOA; a step-care, factorial design model that allows for more than two dozen pair-wise treatment comparisons; phenotyping to improve selection for each therapy (i.e., precision medicine), which is expected to refine outcomes and reduce unnecessary interventions; integration of a psychosocial intervention WITH medication treatment; a novel design; longitudinal follow-up period; personalized medicine approach; an innovative flexible approach to sample size; deep integration into standard of care and the clinical environment; multiple recruitment sites and a collaboration with multiple groups to support the study, including a number of ICs at NIH, primarily NIAMS and NCATS, a Clinical Coordinating Center (at Duke), Data Coordinating Center (at Utah), Recruitment and Retention support (via Vanderbilt and the Duke Call Center) and startup support within Johns Hopkins (Bios/Trials Innovation center), which provide incredibly rich and varied learning opportunities.

摘要/摘要 学术界加速了人们从学术界转向工业、政府和其他部门的职业生涯。 鉴于 COVID-19 大流行，资金支付线紧张，终身教职和终身教职的短缺和激烈完成。 越来越多地跟踪大学/学术医疗机构的职位和“发表或灭亡”的心态 研究生、博士后甚至住院医师都希望离开学术医学领域 追求更稳定和更有利可图的职业需要初级调查员的支持、指导和培训。 不幸的是，有机会播下发展成为并留住知名疼痛科学家的种子。 当前职业中期和高级教师成功的算法不包括开发下一代 我们充满挑战的学术医学领域的领导者当前的资助机制是一个出色的。 导师有机会为对以下领域感兴趣的初级研究人员投入时间、精力和资金 当前的申请旨在为克劳迪娅博士提供受保护的以指导为重点的时间。 Campbell 是“SKOAP”III 期临床试验的 MPI。SKOAP 研究是一项针对癌症的测序策略。 改善膝骨关节炎疼痛患者的治疗结果是一项连续的大规模治愈效果 研究网络研究评估保守和非手术程序干预措施以减轻疼痛 并改善 KOA 患者的功能 该试验是初级培训的绝佳平台。 SKOAP 试验旨在通过首先测试来模拟临床护理。 保守治疗和非手术介入手术的有效性。 比较有效性研究涉及前所未有的全面和创新方法 在这种情况下被采用，在多个领域提供了一个令人兴奋的学习平台，包括： 多学科研究人员进行迄今为止最大规模的随机试验来评估行为、 KOA 的药理学和程序干预；逐步护理、析因设计模型，允许更多 超过两打的成对治疗比较；表型分析，以改善每种治疗的选择（即， 精准医学），有望改善结果并减少不必要的干预； 结合药物治疗的心理社会干预；纵向随访期； 个性化医疗方法；深入整合样本量的创新灵活方法； 护理标准和临床环境；多个招募地点以及与多个机构的合作 支持这项研究的团体，包括 NIH 的许多 IC，主要是 NIAMS 和 NCATS（一个临床研究中心） 协调中心（杜克大学）、数据协调中心（犹他州）、招聘和保留支持（通过 范德比尔特大学和杜克大学呼叫中心）以及约翰霍普金斯大学（Bios/试验创新中心）内的启动支持， 它提供了极其丰富多样的学习机会。

项目成果

Perioperative insomnia trajectories and functional outcomes after total knee arthroplasty.

全膝关节置换术后围手术期失眠轨迹和功能结果。

• DOI: 10.1097/j.pain.0000000000002977
• 发表时间: 2023
• 期刊: Pain
• 影响因子: 7.4
• 作者: Hamilton,KatrinaR;Hughes,AbbeyJ;Campbell,ClaudiaM;Owens,MichaelA;Pester,BethanyD;Meints,SamanthaM;Taylor,JanieceL;Edwards,RobertR;Haythornthwaite,JenniferA;Smith,MichaelT
• 通讯作者: Smith,MichaelT

Multicenter study evaluating factors associated with treatment outcome for low back pain injections.

• DOI: 10.1136/rapm-2021-103247
• 发表时间: 2022-02
• 期刊: REGIONAL ANESTHESIA AND PAIN MEDICINE
• 影响因子: 5.1
• 作者: Cohen, Steven P.;Doshi, Tina L.;Kurihara, Connie;Reece, David;Dolomisiewicz, Edward;Phillips, Christopher R.;Dawson, Timothy;Jamison, David;Young, Ryan;Pasquina, Paul F.
• 通讯作者: Pasquina, Paul F.

Presurgical sleep and pain behaviors predict insomnia symptoms and pain after total knee arthroplasty: a 12-month longitudinal, observational study.

术前睡眠和疼痛行为可预测全膝关节置换术后的失眠症状和疼痛：一项为期 12 个月的纵向观察性研究。

• DOI: 10.1093/pm/pnad106
• 发表时间: 2023
• 期刊: Pain medicine (Malden, Mass.)
• 作者: Owens,MichaelA;Mun,ChungJung;Hamilton,KatrinaR;Hughes,Abbey;Campbell,ClaudiaM;Edwards,RobertR;Smith,MichaelT
• 通讯作者: Smith,MichaelT

Nonorganic (Behavioral) Signs and Their Association With Epidural Corticosteroid Injection Treatment Outcomes and Psychiatric Comorbidity in Cervical Radiculopathy: A Multicenter Study.

非器质性（行为）体征及其与硬膜外皮质类固醇注射治疗结果和颈椎神经根病精神合并症的关联：一项多中心研究。

• DOI: 10.1016/j.mayocp.2022.11.022
• 发表时间: 2023
• 期刊: Mayo Clinic proceedings
• 影响因子: 8.9
• 作者: Cohen,StevenP;Doshi,TinaL;Dolomisiewicz,Edward;Reece,DavidE;Zhao,Zirong;Anderson-White,Mirinda;Kasuke,Angelia;Wang,EricJ;Hsu,Annie;Davis,SheltonA;Yoo,Yongjae;Pasquina,PaulF;Moon,JeeYoun
• 通讯作者: Moon,JeeYoun

Problems With O'Connell et al, "Implanted Spinal Neuromodulation Interventions for Chronic Pain in Adults" (Cochrane Review).

OConnell 等人的问题，“针对成人慢性疼痛的植入性脊髓神经调节干预措施”（Cochrane 评论）。

• DOI: 10.1016/j.neurom.2023.03.005
• 发表时间: 2023
• 期刊: Neuromodulation : journal of the International Neuromodulation Society
• 作者: Russo,MarcA;Bhatia,Anuj;Hayek,Salim;Doshi,Tina;Eldabe,Sam;Huygen,Frank;Levy,RobertM
• 通讯作者: Levy,RobertM