The Impact of Environmental Stressors on Chronic Disease Disparities in Women

环境压力因素对女性慢性病差异的影响

• 批准号: 10298166
• 负责人: NICOLE R NUGENT
• 金额: --
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2021-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10298166
• 关键词: Acceleration; Age; Aging; Behavior; Behavioral; Biological; Biological Aging; Biological Process; Blood specimen; Cardiovascular Diseases; Caring; Cell Aging; Characteristics; Chronic; Chronic Disease; Collection; Communities; Complex; DNA Methylation; Data; Data Collection; Deceleration; Development; Diabetes Mellitus; Disasters; Disease; Economically Deprived Population; Economics; Environment; Environmental Impact; Epigenetic Process; Exposure to; Financial Hardship; Gene Expression; Geography; Goals; Health; Health behavior; Healthy Eating; Hypertension; Income; Individual; Individual Differences; Informal Social Control; Intervention; Life Cycle Stages; Louisiana; Low Income Population; Lung diseases; Malignant Neoplasms; Measurable; Measures; Mediating; Medical; Medical History; Mental Depression; Mental Health; Methods; Minority; Modification; Neighborhoods; Obesity; Oils; Outcome; Outcome Study; Participant; Patient Self-Report; Physical activity; Physical environment; Population; Post-Traumatic Stress Disorders; Process; Race; Recording of previous events; Reporting; Research; Resources; Rural; Sampling; Smoking; Social Behavior; Social Environment; Stress; Telephone Interviews; Testing; Time; Trauma; Woman; adverse outcome; age related; base; cohort; disadvantaged population; disease disparity; drinking; environmental stressor; experience; health data; health disparity; health disparity populations; indexing; novel; novel strategies; physical conditioning; prevent; psychologic; psychological symptom; resilience; social; social capital; social disadvantage; social stressor; stressor; therapy development; trauma exposure; traumatic stress

Project Summary The overall objective of this project is to determine the impact of social stressors on epigenetic age acceleration and chronic health disparities and to test whether the social environment, individual health behaviors, and race/geography/SES modify or mediate the association between traumatic stress and health (disparities), directly or indirectly through biologic age acceleration. We expect that the trauma burden will impact chronic diseases through DNA methylation (DNAm) age acceleration. The WaTCH cohort is an important, highly trauma- exposed sample of women uniquely poised for a third wave of data collection that continues assessing trauma exposure, depression, PTSD, social context, physical health, and collection of an additional blood specimen eight years after the baseline to examine of DNAm age. Aim 1 will investigate disparities in psychological health (PTSD, depression), physical health (diabetes, hypertension, and cancer), and DNAm age acceleration as women age, particularly as influenced by cumulative trauma burden. Aim 2 will examine the influences of contextual variables, including social capital and financial strain, that may mediate or moderate the effects of cumulative trauma burden on adverse psychological and physical health outcomes. Aim 3 will explore the mediating effects of DNAm age acceleration on physical and mental health outcomes. The proposed study will use the WaTCH cohort of 2800 women exposed to the Deepwater Horizon Oil Spill in coastal Louisiana in 2010. It will entail the third wave of data and biospecimen collection and incorporate data already gathered through two previous waves of data collection. Self-reported health data on demographic, income and financial stressors, oil spill exposure, neighborhood context, social capital, health behaviors, trauma history, psychological symptoms, and physical health will be collected through telephone interviews. Repeat blood samples will be collected from up to 1058 women with baseline samples.

项目摘要 该项目的总体目的是确定社会压力源对表观遗传的影响 年龄加速和慢性健康差异，并测试社会环境是否存在 个人健康行为，种族/地理/SES修改或调解协会 直接或间接到生物年龄，在创伤压力和健康（差异）之间 加速度。我们预计创伤负担会通过DNA影响慢性疾病 甲基化（DNAM）年龄加速度。手表队列是一个重要的，高度的创伤 - 裸露的妇女样本独特地准备为第三波数据收集，继续 评估创伤暴露，抑郁，PTSD，社会环境，身体健康以及收集 基线八年后，检查DNAM时代的额外血液标本。目标1意志 调查心理健康方面的差异（PTSD，抑郁症），身体健康（糖尿病，， 随着女性的年龄，高血压和癌症）以及DNAM年龄的加速度，尤其是 受累积创伤负担的影响。 AIM 2将检查上下文的影响 变量，包括社会资本和财务压力，可能导致或缓和影响 累积的创伤负担对不利的心理和身体健康成果。目标3意志 探索DNAM年龄加速对身心健康的中介作用 结果。 拟议的研究将使用暴露于深水的2800名妇女的手表队列 2010年，路易斯安那州沿海地区的地平线漏油事件将需要第三次数据浪潮和 生物循环收集并合并了已经通过之前的两个波浪收集的数据 数据收集。关于人口统计，收入和财务压力源，石油的自我报告的健康数据 溢出暴露，邻里环境，社会资本，健康行为，创伤历史， 心理症状和身体健康将通过电话访谈收集。 重复的血液样本将从最多1058名具有基线样本的妇女收集。